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Depression, Anhedonia, and Psychomotor Symptoms: The Role of Dopaminergic Neurocircuitry

Published online by Cambridge University Press:  07 November 2014

Dan J. Stein
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Abstract

The heterogeneity of major depression suggests that multiple neurocircuits and neurochemicals are involved in its pathogenesis. Anhedonia and psychomotor symptoms are, however, particularly characteristic features of major depression and may provide insights into its underlying psychobiology. Importantly, these symptoms appear to be mediated by dopaminergic mesolimbic and mesostriatal projections, the function of which is, in turn, influenced by key gene variants and environment stressors. Indeed, there is growing evidence of the way in which the dopaminergic system is associated with cognitive-affective disturbances in depression, and provides a useful target for therapeutic interventions. At the same time, a range of other systems are likely to contribute to the psychobiology of this condition.

Type
Pearls in Clinical Neuroscience
Information
CNS Spectrums , Volume 13 , Issue 7 , July 2008 , pp. 561 - 565
Copyright
Copyright © Cambridge University Press 2008

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References

REFERENCES

1.Davidson, RJ, Pizzagalli, D, Nitschke, JB, Putnam, K. Depression: perspectives from affective neuroscience. Annu Rev Psychol. 2002,53:545–574.CrossRefGoogle ScholarPubMed
2.Stahl, SM, Zhang, L, Damatarca, C, Grady, M. Brain circuits determine destiny in depression: a novel approach to the psychopharmacology of wakefulness, fatigue, and executive dysfunction in major depressive disorder. J Clin Psychiatry. 2003;64(suppl):6–17.Google Scholar
3.Mayberg, HS, Liotti, M, Brannan, SK, et al.Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry. 1999:156:675–682.CrossRefGoogle ScholarPubMed
4.Klein, DF. Endogenomorphic depression. A conceptual and terminological revision. Arch Gen Psychiatry. 1974;31:447–454.CrossRefGoogle ScholarPubMed
5.Snaith, P. Anhedonia: a neglected symptom of psychopathology. Psychol Med. 1993:23:957–966.CrossRefGoogle ScholarPubMed
6.Chiu, PH, Deldin, PJ. Neural evidence for enhanced error detection in major depressive disorder. Am J Psychiatry. 2007:164:608–616.CrossRefGoogle ScholarPubMed
7.Nestler, EJ, Carlezon, WA Jr.The mesolimbic dopamine reward circuit in depression. Biol Psychiatry. 2006:59:1151–1159.CrossRefGoogle ScholarPubMed
8.Nutt, DJ. The role of dopamine and norepinephrine in depression and antidepressant treatment. J Clin Psychiatry. 2006:67(suppl):3–8.Google ScholarPubMed
9.Sobin, C, Sackeim, HA. Psychomotor symptoms of depression. Am J Psychiatry. 1997:154:4–17.Google ScholarPubMed
10.Schrijvers, D, Hulstijn, W, Sabbe, BG. Psychomotor symptoms in depression: a diagnostic, pathophysiological and therapeutic tool. J Affect Disord. 2008:109:1–20.CrossRefGoogle ScholarPubMed
11.Parker, G. Classifying depression: should paradigms lost be regained? Am J Psychiatry. 2000:157:1195–1203.CrossRefGoogle ScholarPubMed
12.Knutson, B, Fong, GW, Adams, CM, Varner, JL, Hommer, D. Dissociation of reward anticipation and outcome with eventrelated fMRI. Neuroreport. 2001:12:3683–3687.CrossRefGoogle ScholarPubMed
13.Bevins, RA, Besheer, J. Novelty reward as a measure of anhedonia. Neurosci Biobehav Rev. 2005:29:707–714.CrossRefGoogle ScholarPubMed
14.Anisman, H, Matheson, K. Stress, depression, and anhedonia: caveats concerning animal models. Neurosci Biobehav Rev. 2005:29:525–546.CrossRefGoogle ScholarPubMed
15.Willner, P, Klimek, V, Golembiowska, K, Muscat, R. Changes in mesolimbic dopamine may explain stressinduced, anhedonia. Psychobiology. 1991:19:79–84.CrossRefGoogle Scholar
16.Bhatia, KP, Marsden, CD. The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain. 1994;117(pt 4):859–876.CrossRefGoogle ScholarPubMed
17.Miller, JM, Vorel, SR, Tranguch, AJ, et al.Anhedonia after a selective bilateral lesion of the globus pallidus. Am J Psychiatry. 2006:163:786–788.CrossRefGoogle ScholarPubMed
18.Mitterschiffthaler, MT, Kumari, V, Malhi, GS, et al.Neural response to pleasant stimuli in anhedonia: an fMRI study. Neuroreport. 2003:14:177–182.CrossRefGoogle ScholarPubMed
19.Keedwell, PA, Andrew, C, Williams, SC, Brammer, MJ, Phillips, ML. The neural correlates of anhedonia in major depressive disorder. Biol Psychiatry. 2005:58:843–853.CrossRefGoogle ScholarPubMed
20.Harvey, PO, Pruessner, J, Czechowska, Y, Lepage, M. Individual differences in trait anhedonia: a structural and functional magnetic resonance imaging study in nonclinical subjects. Mol Psychiatry. 2007:12:703,767–775.CrossRefGoogle Scholar
21.Epstein, J, Pan, H, Kocsis, JH, et al.Lack of ventral striatal response to positive stimuli in depressed versus normal subjects. Am J Psychiatry. 2006:163:1784–1790.CrossRefGoogle ScholarPubMed
22.Dunn, RT, Kimbrell, TA, Ketter, TA, et al.Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depression. Biol Psychiatry. 2002:51:387–399.CrossRefGoogle ScholarPubMed
23.Videbach, P. PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review. Acta Psychiatr Scand. 2000:101:11–20.CrossRefGoogle Scholar
24.Demyttenaere, K, De Fruyt, J, Stahl, SM. The many faces of fatigue in major depressive disorder. Int J Neuropsychopharmacol. 2005:8:93–105.CrossRefGoogle ScholarPubMed
25.Klimke, A, Larisch, R, Janz, A, Vosberg, H, Muller-Gartner, HW, Gaebel, W. Dopamine D2 receptor binding before and after treatment of major depression measured by [123I]IBZM SPECT. Psychiatry Res. 1999:90:91–101.CrossRefGoogle ScholarPubMed
26.Nikolaus, S, Antke, C, Kley, K, et al.Investigating the dopaminergic synapse in vivo.I. Molecular imaging studies in humans. Rev Neurosci. 2007:18:439–472.Google ScholarPubMed
27.Martinot, MLP, Bragulat, V, Artiges, E, et al.Decreased presynaptic dopamine function in the left caudate of depressed patients with affective flattening and psychomotor retardation. Am J Psychiatry. 2001:158:314–316.CrossRefGoogle ScholarPubMed
28.Meyer, JH, McNeely, HE, Sagrati, S, et al.Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study. Am J Psychiatry. 2006:163:1594–1602.CrossRefGoogle ScholarPubMed
29.Narita, H, Odawara, T, Iseki, E, Kosaka, K, Hirayasu, Y. Psychomotor retardation correlates with frontal hypoperfusion and the Modified Stroop Test in patients under 60-years-old with major depression. Psychiatry Clin Neurosci. 2004:58:389–395.CrossRefGoogle ScholarPubMed
30.Tremblay, LK, Naranjo, CA, Graham, SJ, et al.Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe. Arch Gen Psychiatry. 2005:62:1228–1236.CrossRefGoogle ScholarPubMed
31.Pogarell, O, Koch, W, Popperl, G, et al.Acute prefrontal rTMS increases striatal dopamine to a similar degree as D-amphetamine. Psychiatry Res. 2007:156:251–255.CrossRefGoogle ScholarPubMed
32.Schlaepfer, TE, Cohen, MX, Frick, C, et al.Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology. 2008:33:368–377.CrossRefGoogle ScholarPubMed
33.Nutt, D, Demyttenaere, K, Janka, Z, et al.The other face of depression, reduced positive affect: the role of catecholamines in causation and cure. J Psychopharmacol. 2007:21:461–471.CrossRefGoogle ScholarPubMed
34.Salamone, JD, Cousins, MS, Snyder, BJ. Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis. Neurosci Biobehav Rev. 1997:21:341–359.CrossRefGoogle ScholarPubMed
35.Dremencov, E, Gispan-Herman, I, Rosenstein, M, et al.The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2004:28:141–147.CrossRefGoogle ScholarPubMed
36.Del Arco, A, Mora, F. Prefrontal cortex-nucleus accumbens interaction: in vivo modulation by dopamine and glutamate in the prefrontal cortex. Pharmacol Biochem Behav. 2008:90:226–235.CrossRefGoogle ScholarPubMed
37.Leknes, S, Tracey, I. A common neurobiology for pain and pleasure. Nat Rev Neurosci. 2008:9:314–320.CrossRefGoogle ScholarPubMed
38.Koob, G, Kreek, MJ. Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry. 2007:164:1149–1159.CrossRefGoogle ScholarPubMed
39.Eisch, AJ, Bolaños, CA, de Wit, J, et al.Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol Psychiatry. 2003:54:994–1005.CrossRefGoogle ScholarPubMed
40.Slevin, JT, Gash, DM, Smith, CD, et al.Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal. J Neurosurg. 2007:106:614–620.CrossRefGoogle ScholarPubMed
41.Meyer, JH, McMain, S, Kennedy, SH, et al.Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm. Am J Psychiatry. 2003;160:90–99.CrossRefGoogle ScholarPubMed
42.Bogan, R, Pizzagalli, DA. The heritability of hedonic capacity and perceived stress: a twin study evaluation of candidate depressive phenotypes. Psychol Med. In press.Google Scholar
43.Hasler, G, Drevets, WC, Manji, HK, Charney, DS. Discovering endophenotypes for major depression. Neuropsychopharmacology. 2004:29:1765–1781.CrossRefGoogle ScholarPubMed
44.Panksepp, J. Affective Neuroscience: The Foundations of Human and Animal Emotions. New York, NY: Oxford University Press: 1998.CrossRefGoogle Scholar
45.Haeffel, GJ, Getchell, M, Koposov, RA, et al.Association between polymorphisms in the dopamine transporter gene and depression: evidence for a gene-environment interaction in a sample of juvenile detainees. Psychol Sci. 2008:19:62–69.CrossRefGoogle Scholar
46.Elovainio, M, Jokela, M, Kivimaki, M, et al.Genetic variants in the DRD2 gene moderate the relationship between stressful life events and depressive symptoms in adults:cardiovascular risk in young Finns study. Psychosom Med. 2007:69:391–395.CrossRefGoogle ScholarPubMed
47.Uher, R, McGuffin, P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry. 2008:13:131–146.CrossRefGoogle ScholarPubMed
48.Brown, GW, Harris, TO. Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction. J Affect Disord. 2008 Jun 3. [Epub ahead of print].Google Scholar
49.Klein, TA, Neumann, J, Reuter, M, Hennig, J, von Cramon, DY, Ullsperger, M. Genetically determined differences in learning from errors. Science.2007:318:1642–1645.CrossRefGoogle ScholarPubMed
50.Nesse, RM. Is depression an adaptation? Arch Gen Psychiatry. 2000:57:14–20.CrossRefGoogle ScholarPubMed
51.Allen, NB, Badcock, PB. Darwinian models of depression: a review of evolutionary accounts of mood and mood disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2006:30:815–826.CrossRefGoogle ScholarPubMed
52.De La Garza, R 2nd. Endotoxin- or pro-inflammatory cytokine-induced sickness behavior as an animal model of depression: focus on anhedonia. Neurosci Biobehav Rev. 2005:29:761–770.CrossRefGoogle ScholarPubMed
53.Taylor, MA, Fink, M. Restoring melancholia in the classification of mood disorders. J Affect Disord. 2008:105:1–14.CrossRefGoogle ScholarPubMed
54.Leventhal, AM, Chasson, GS, Tapia, E, Miller, EK, Pettit, JW. Measuring hedonic capacity in depression: a psychometric analysis of three anhedonia scales. Journal Of Clinical Psychology. 2006:62:1545–1558.CrossRefGoogle ScholarPubMed
55.Sobin, C, Mayer, L, Endicott, J. The motor agitation and retardation scale: a scale for the assessment of motor abnormalities in depressed patients. J Neuropsychiatry Clin Neurosci. 1998:10:85–92.CrossRefGoogle Scholar
56.Zimmerman, M, Postemak, MA, Attiullah, N, et al.Why isn't bupropion the most frequently prescribed antidepressant? J Clin Psychiatry. 2005:66:603–610.CrossRefGoogle ScholarPubMed
57.Dailly, E, Chenu, F, Renard, CE, Bourin, M. Dopamine, depression and antidepressants. Fundamental & Clinical Pharmacology. 2004:18:601–607.CrossRefGoogle ScholarPubMed