Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-16T01:55:07.329Z Has data issue: false hasContentIssue false

Methylphenidate-Induced Obsessive-Compulsive Symptoms in an Elderly Man

Published online by Cambridge University Press:  07 November 2014

Abstract

An 82-year-old man with treatment-resistant depression and early Alzheimer's disease was started on methylphenidate. Significant obsessive-compulsive behavior ensued but diminished over several weeks when methylphenidate was replaced by fluvoxamine. The patient had no prior psychiatric history, but he had a sister with obsessive-compulsive disorder. It appears that methylphenidate precipitated the patient's pathological behavior.

Type
Case Report
Copyright
Copyright © Cambridge University Press 2003

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Kozumi, HM. Obsessive-compulsive symptoms following stimulants. Biol Psychiatry. 1985;20:13321337.CrossRefGoogle Scholar
2.Kouris, S. Methylphenidate-induced obsessive-compulsiveness [letter]. J Acad Child Adolesc Psychiatry. 1998;37:135.CrossRefGoogle ScholarPubMed
3.Kuczenski, R, Segal, DS. Sensitization of amphetamine-induced stereotyped behaviors during the acute response. J Pharmacol Exp Ther. 1999;288:699709.Google ScholarPubMed
4.Stein, DJ. Neurobiology of the obsessive-compulsive spectrum disorders. Biol Psychiatry. 2000;47:296304.CrossRefGoogle ScholarPubMed
5.Laviolette, SR, Priebe, RP, Yeomans, JS. Role of the laterodorsal tegmental nucleus in scopolamine- and amphetamine-induced locomotion and stereotypy. Pharmacol Biochem Behav. 2000;65:163174.CrossRefGoogle ScholarPubMed
6.Serby, M, Yu, M. Overview: depression in the elderly. Mount Sinai J Med.Google Scholar