Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-10T09:09:01.610Z Has data issue: false hasContentIssue false

Pregnancy and Stroke

Published online by Cambridge University Press:  07 November 2014

Abstract

The risks of ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage are not increased in the 9 months of gestation except for a high risk in the 2 days prior and 1 day postpartum. The remaining 6 weeks postpartum also have an increased risk of ischemic stroke and intracerebral hemorrhage, though less than the peripartum period. Although there are some rare causes of stroke specific to pregnancy and the postpartum period, eclampsia, cardiomyopathy, postpartum cerebral venous thrombosis, and, possibly, paradoxical embolism warrant special consideration. The diagnostic and therapeutic approaches to stroke during pregnancy and the postpartum period are similar to the approaches in the nonpregnant woman with some minor modifications based on consideration of the welfare of the fetus. There is a theoretical risk of magnetic resonance imaging exposure during the first and second trimester but the benefit to the mother of obtaining the information may outweigh the risk. Available evidence suggests that low-dose aspirin (<150 mg/day) during the second and third trimesters is safe for both mother and fetus. Postpartum use of low-dose aspirin by breast-feeding mother is also safe for infant. While proper counseling is imperative, a history of pregnancy-related stroke should not be a contraindication for subsequent pregnancy.

Type
Review Articles
Copyright
Copyright © Cambridge University Press 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Sharshar, T, Lamy, C, Mas, JL. Incidence and causes of strokes associated with pregnancy and puerperium. A study in public hospitals of Ile de France. Stroke in Pregnancy Study Group. Stroke. 1995;26:930936.Google Scholar
2.Kittner, SJ, Stern, BJ, Feeser, BR, et al.Pregnancy and the risk of stroke. N Engl J Med. 1996;335:768774.Google Scholar
3.Schaefer, PW. Diffusion-weighted imaging as a problem-solving tool in the evaluation of patients with acute strokelike syndromes. Top Magn Reson Imaging. 2000;11:300309.Google Scholar
4.Shah, AK, Whitty, JE. Brain, MRI in peripartum seizures: usefulness of combined T2 and diffusion weighted MR imaging. J Neurol Sci. 1999;166:122125.Google Scholar
5.Jaigobin, C, Silver, FL. Stroke and pregnancy. Stroke. 2000;31:29482951.Google Scholar
6.Witlin, AG, Mattar, F, Sibai, BM. Postpartum stroke: a twenty-year experience. Am J Obstet Gynecol. 2000;183:8388.Google Scholar
7.Roberts, JM, Pearson, G, Cutler, J, Lindheimer, M. Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertension. 2003;41:437445.Google Scholar
8.Kaplan, PW. Neurologic aspects of eclampsia. Neurol Clin. 2004;22:841861.Google Scholar
9.Lain, KY, Roberts, JM. Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA. 2002;287:31833186.Google Scholar
10.ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists. ACOG Committee on Obstetric Practice. Int J Gynaecol Obstet. 2002;77:6775.Google Scholar
11.Martin, JN Jr, Thigpen, BD, Moor, RC, Rose, CH, Cushman, J, May, W. Stroke and severe preeclampsia an declampsia: a paradigm shift focusing on systolic blood pressure. Obstet Gynecol. 2005;105:246254.Google Scholar
12.Fett, JD. Peripartum cardiomyopathy. Insights from Haiti regarding a disease of unknown etiology. Minn Med. 2002;85:4648.Google Scholar
13.Elkayam, U, Tummala, PP, Rao, K, et al.Maternal and fetal outcomes in women with peripartum cardiomyopathy. N Engl J Med. 2001;344:15671571.Google Scholar
14.Ford, RF, Barton, JR, O'brien, JM, Hollingsworth, PW. Demographics, management, and outcome of peripartum cardiomyopathy in a community hospital. Am J Obstet Gynecol. 2000;182:10361038.Google Scholar
15.Kozelj, M, Novak-Antolic, Z, Grad, A, Peternel, P. Patent foramen ovale as a potential cause of paradoxical embolism in the postpartum period. Eur J Obstet Gynecol Reprod Biol. 1999;84:5557.Google Scholar
16.Brey, RL, Coull, BM. Cerebral venous thrombosis. Role of activated protein C resistance and factor V gene mutation. Stroke. 1996;27:17191720.Google Scholar
17.Deschiens, MA, Conard, J, Horellou, MH, et al.Coagulation studies, factor V Leiden, and anticardiolipin antibodies in 40 cases of cerebral venous thrombosis. Stroke. 1996;27:17241730.CrossRefGoogle ScholarPubMed
18.Cakmak, S, Derex, L, Berruyer, M, et al.Cerebral venous thrombosis: clinical outcome and systematic screening of prothrombotic factors. Neurology. 2003;60:1175–8.CrossRefGoogle ScholarPubMed
19.Richards, A, Graham, D, Bullock, R. Clinicopathological study of neurological complications due to hypertensive disorders of pregnancy. J Neurol Neurosurg Psychiatry. 1988;51:416421.Google Scholar
20.Sadasivan, B, Malik, G, Lee, C, Ausman, J. Vascular malformations and pregnancy. Surg Neurol. 1990;33:305313.Google Scholar
21.Hunt, H, Shifrin, B, Suzuki, K. Ruptured berry aneurysms and pregnancy. Obstet Gynecol. 1974;43:827836.Google Scholar
22.Geocadin, RG, Razumovsky, AY, Wityk, RJ, Bhardwaj, A, Ulatowski, JA. Intracerebral hemorrhage and postpartum cerebral vasculopathy. J Neurol Sci. 2002;205:2934.Google Scholar
22.Granier, I, Garcia, E, Geissler, A, Boespflug, MD, Gasselin, J. Postpartum cerebral angiopathy associated with administration of sumatriptan and dihydroergotamine—case report. Intensive Care Med. 1999;25:532534.Google Scholar
24.Janssens, E, Hommel, M, Monier-Vehier, M, et al.Postpartum cerebral angiopathy possibly due to bromocriptine therapy. Stroke. 1995;26:128130.Google Scholar
25.Singhal, AB, Caviness, VS, Begleiter, AF, Mark, EJ, Rordorf, G, Koroshetz, WJ. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology. 2002;58:13011333.Google Scholar
26.Geraghty, JJ, Hock, DB, Robert, ME, Vinters, HV. Fatal puerperal cerebral vasospasm and stroke in a young women. Neurology. 1991;41:11451147.Google Scholar
27.Singhal, AB. Postpartum angiopathy with reversible posterior leukoencephalopathy. Arch Neurol. 2004;61:411416.Google Scholar
28.Ursell, MR, Marras, CL, Farb, R, Rowed, DW, Black, SE, Perry, JR. Recurrent intracranial hemorrhage due to postpartum cerebral angiopathy: implications for management. Stroke. 1998;29:19951998.Google Scholar
29.Garner, BF, Burns, P, Bunning, RD, Laurena, R. Acute blood pressure elevation can mimic arteriographic appearance of cerebral vasculitis–(a postpartum case with relative hypertension). J Rheumatol. 1990;17:9397.Google ScholarPubMed
30.Fox, MW, Harms, RW, Davis, DH. Selected neurologic complications of pregnancy. Mayo Clin Proc. 1990;65:15951618.CrossRefGoogle ScholarPubMed
31.Momma, F, Beck, H, Miyamoto, T, Nagao, S. Intracranial aneurysm due to metastatic choriocarcinoma. Surg Neurol. 1986;25:7476.Google Scholar
32.Tuffnell, DJ. Amniotic fluid embolism. Curr Opin Obstet Gynecol. 2003;15:119122.Google Scholar
33.Muth, CM, Shank, ES. Primary care: Gas embolism. N Engl J Med. 2000;342:476482.Google Scholar
34.Cross, JN, Castro, PO, Jennett, WB. Cerebral strokes associated with pregnancy and the puerperium. Br Med J. 1968;3:214218.Google Scholar
35.Wiebers, DO, Whisnant, JP. The incidence of stroke among pregnant women in Rochester, Minn, 1955 through 1979. JAMA. 1985;254:30553057.Google Scholar
36.Lidegaard, O. Oral contraception and risk of a cerebral thromboemholic attack: results of a case-control study. BMJ. 1993;306:956963.CrossRefGoogle ScholarPubMed
37.Kittner, SJ, McCarter, RJ, Sherwin, RW, et al.Black-white differences in stroke risk among young adults. Stroke. 1993;24(12 suppl):I13I15.Google Scholar
38.Ros, HS, Lichtenstein, P, Bellocco, R, Petersson, G, Cnattingius, S. Increased risks of circulatory diseases in the late pregnancy and puerperium. Epidemiology. 2001;12:456460.Google Scholar
39.Nencini, P, Inzitari, D, Baruffi, MC, et al.Incidence of stroke in young adults in Florence, Italy. Stroke. 1988;19:977981.CrossRefGoogle ScholarPubMed
40.Ros, HS, Lichtenstein, P, Bellocco, R, Petersson, G, Cnattingius, S. Pulmonary embolism and stroke in relation to pregnancy: how can high-risk women be identified? Am J Obstet Gynecol. 2002;186:198203.Google Scholar
41.Lanska, DJ, Kryscio, RJ. Peripartum stroke and intracranial venous thrombosis in the National Hospital Discharge Survey. Obstet Gynecol. 1997;89:413418.Google Scholar
42.Lanska, DJ, Kryscio, RJ. Stroke and intracranial venous thrombosis during pregnancy and puerperium. Neurology. 1998;51:16221628.CrossRefGoogle ScholarPubMed
43.Lanska, DJ, Kryscio, RJ. Risk factors for peripartum and postpartum stroke and intracranial venous thrombosis. Stroke. 2000;31:12741282.Google Scholar
44.Witlin, AG, Friedman, SA, Egerman, RS, Frangieh, AY, Sibai, BM. Cerebrovascular disorders complicating pregnancy–beyond eclampsia. Am J Obstet Gynecol. 1997;176:11391145.Google Scholar
45.Hellgren, M. Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost. 2003;29:125130.Google Scholar
46.Cipolla, MJ, Vitullo, L, McKinnon, J. Cerebral artery reactivity changes during pregnancy and the postpartum period: a role in eclampsia? Am J Physiol Heart Circ Physiol. 2004;286:H2127H2132.Google Scholar
47.Wilterdink, JL, Easton, JD. Cerebral ischemia in pregnancy. Adv Neurol. 2002;90:5162.Google ScholarPubMed
48.Schwartz, RB. Neuroradiographic imaging: techniques and safety considerations. Adv Neurol. 2002;90:18.Google Scholar
49.Tyndall, DA, Sulik, KK. Effects of magentic resonance imaging on eye development in the C57BL/6J mouse. Teratology. 1991;43:263275.Google Scholar
50.Heinrichs, WL, Fong, P, Flannery, M, et al.Midgestational exposure of pregnant BALB/c mice to magnetic resonance imaging conditions. Magn Reson Imaging. 1988;6:305311.Google Scholar
51.Mas, JL, Lamy, C. Stroke in pregnancy and the puerperium. J Neurol. 1998;245:305313.Google Scholar
52.Dias, MS, Sekhar, LN. Intracranial hemorrhage from aneurysms and arteriovenous malformations during pregnancy and the puerperium. Neurosurgery. 1990;27:855865.Google Scholar
53.Piotin, M, de Souza Filho, CB, Kothimbakam, R, Moret, J. Endovascular treatment of acutely ruptured intracranial aneurysms in pregnancy. Am J Obstet Gynecol. 2001;185:12611262.Google Scholar
54.Roman, H, Descargues, G, Lopes, M, et al.Subarachnoid hemorrhage due to cerebral aneurismal rupture during pregnancy. Acta Obstet Gynecol Scand. 2004;83:330334.Google Scholar
55.Wilterdink, JL, Feldman, E. Intracranial hemorrhage. Adv Neurol. 2002;90:6374.Google Scholar
56.Horton, JC, Chambers, WA, Lyons, SL, Adams, RD, Kjellbert, RN. Pregnancy and the risk of hemorrhage from cerebral arteriovenous malformations. Neurosurgery. 1990;27:867871.Google Scholar
57.Elford, K, Leader, A, Wee, R, Stys, PK. Stroke in ovarian hyperstimulation syndrome in early pregnancy treated with intra-arterial rt-PA. Neurology. 2002;59:12701272.Google Scholar
58.Lamy, C, Hamon, JB, Coste, J, Mas, JL. Ischemic stroke in young women: risk of recurrence during subsequent pregnancies. French Study Group on Stroke in Pregnancy. Neurology. 2000;55:269274.Google Scholar
59.Bates, SM, Greer, IA, Hirsh, J, Ginsberg, JS. Use of antithrombotic agents during pregnancy: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004:126(3 suppl):627S644S.Google Scholar
60.Imperiale, TF, Petrulis, AS. A meta-analysis of low-dose aspirin for the prevention of pregnancy-induced hypertensive disease. JAMA. 1991;266:260264.Google Scholar
61.Low dose aspirin in pregnancy and early childhood development: follow up of the collaborative low dose aspirin study in pregnancy. CLASP collaborative group. Br J Obstet Gynaecol. 1995;102:861868.CrossRefGoogle Scholar
62.Ito, W, Blajchman, A, Stephenson, M, Eliopoulos, C, Koren, G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:13931399.Google Scholar
63.Bar-Oz, B, Bulkowstein, M, Benyamini, L, et al.Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003;26:925929.Google Scholar
64.Chan, WS, Anand, S, Giasberg, JS. Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature. Arch Intern Med. 2000;160:191196.Google Scholar
65.Wesseling, J, van Driel, D, Heymans, HS, et al.Coumarins during pregnancy: long-term effects on growth and development of school-age children. Thromb Haemost. 2001;85:609613.Google Scholar
66.Simolke, GA, Cox, SM, Cunningham, FG. Cerebrovascular accidents complicating pregnancy and the puerperium. Obstet Gynecol. 1991;78:3742.Google Scholar
67.Mehraein, S, Ortwein, H, Busch, M, Weih, M, Einhaupl, K, Masuhr, F. Risk ot recurrence of cerebral venous and sinus thrombosis during subsequent pregnancy and puerperium. J Neurol Neurosurg Psychiatry. 2003;74:814816.Google Scholar