Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-25T18:38:00.720Z Has data issue: false hasContentIssue false
  • English
  • Français

Psychoneuroendocrinology: A Scientific Domain of the Future or a Dream From the Past?

Published online by Cambridge University Press:  07 November 2014

Francesca Brambilla
Get access Rights & Permissions [Opens in a new window]

Abstract

Psychoneuroendocrinology (PNE) has been a method used in the past to investigate brain biochemical functions in normal and pathological mentation. These studies have subsequently uncovered variations in normal biochemical functioning. It is still being debated, however, how these variations correlate with well-defined psychopathologies.

Future studies in PNE shows promise in many areas of contemporary neurospychiatry. For example, research focusing on variations in neurotransmitter, neuropeptide, and neurohormone secretory tonus might enhance our understanding of specific personality characteristics and behavior. PNE may also be essential in investigating the correlation between hormonal variations and symptoms observed across various psychiatric disorders. PNE might likewise be important for new therapeutic approaches. Finally, PNE can be used to investigate psychoneuroimmunoendocrine relationships.

New PNE methodologies must be developed to make this branch of neuroscience more appropriate for the study of localized brain functions.

Type
Feature Article
Information
CNS Spectrums , Volume 3 , Issue 1: Chaos and Complexity in Neuroscience , January 1998 , pp. 41 - 51
Copyright
Copyright © Cambridge University Press 1998

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Brambilla, F, Bridges, PK, Endroczi, E, Heuser, G. Perspectives in Endocrine Psychobiology. Budapest, Hungary: Akademiai Kiado Press; 1978.Google Scholar
2.Sachar, E. Hormones, Behavior and Psychopathology. New York, NY: Raven Press; 1976.Google Scholar
3.Muller, EE, Nisticò, G, Seapagnini, U. Neurotransmitters and Anterior Pituitary Function. New York, NY: Academic Press; 1977.Google Scholar
4.Shah, NS, Donald, AG. Psychoneuroendocrine Dysfunction. New York, NY: Plenum; 1984.Google Scholar
5.Brown, GM, Koslow, SH, Reichlin, S. Neuroendocrinology and Psychiatric Disorder. New York, NY: Raven Press; 1984.Google Scholar
6.Schatzberg, AF, Nemeroff, C. The Hypothalamic-Pituitary-Adrenal Axis: Physiology, Pathophysiology, and Psychiatric Implications. New York, NY: Raven Press; 1988.Google Scholar
7.De Souza, E, Nemeroff, CB. Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide. Boca Raton, Fla: CRC Press; 1990.Google Scholar
8.Van Praag, HM. Serotonin-related, anxiety/aggression-driven, stressor-precipitated depression: a psychobiology hypothesis. European Psychiatry. 1996;11:57–67.Google Scholar
9.Halbreich, U. Hormones and Depression. New York, NY: Raven Press; 1987.Google Scholar
10.Netter, P, Hennig, J, Roed, IS. Serotonin and dopamine as mediators of sensation seeking behavior. Neuropsychobiology. 1996;34:155–165.Google Scholar
11.Af Klinteberg, B. Biology and personality: a developmental perspective. Neuropsychobiology. 1996;34:146–154.Google Scholar
12.Siever, L, Trestman, RL. The serotonin system and aggressive personality disorder. Int Clin Psychopharmacol. 1993;2(suppl):33–39.CrossRefGoogle Scholar
13.Finkelstein, JW, Susman, EJ, Chinchilli, VM, et al.Estrogen or testosterone increases self-reported aggressive behaviors in hypogonadal adolescents. J Clin Endocrinol Metab. 1997;82:2433–2438.Google ScholarPubMed
14.Mehlman, PT, Hygley, JD, Feruald, BJ, Sallee, FR, Suomi, SJ, Linnoila, M. CSF, 5HIAA, testosterone and sociosexual behaviors in free-engaging male rhesus macaques in the mating season. Psychiatry Res. 1977;72:89–102.Google Scholar
15.Gerra, G, Avanzini, P, Zaimovic, A, et al.Neurotransmitter and endocrine modulation of aggressive behavior and its components in normal humans. Behav Brain Res. 1996;81:19–24.CrossRefGoogle ScholarPubMed
16.Vanderhaegen, JJ, Crawley, JN. Neuronal Cholecystokinin. New York, NY: New York Academy of Sciences; 1985.Google Scholar
17.Nemeroff, CB, Dunn, AJ. Peptides, Hormones and Behavior. Lancaster, United Kingdom: Falcon House; 1984.Google Scholar
18.De Wied, D. Neuropeptides: Basics and Perspectives. Amsterdam, The Netherlands: Elsevier Science; 1990.Google Scholar
19.Murphy, BEP, Dhar, V, Ghadirian, AM, Chouinard, G, Keller, R. Response to steroid suppression in major depression resistant to antidepressant therapy. J Clin Psychopharmacol. 1991;11:121–126.Google Scholar
20.Wolkowitz, O, Reus, VI, Manfredi, F, Ingbar, J, Brizendine, L, Weingartner, H. Ketoconazole administration in hypercortisolemic depression. Am J Psychiatry. 1993;150:810–812.Google Scholar
21.Klaiber, EL, Broverman, DM, Vogel, W, Kobayashi, Y. Estrogen therapy for severe persistent depression in women. Arch Gen Psychiatry. 1979;36:550–554.Google Scholar
22.Oppenheim, G. Estrogen in the treatment of depression: neuropharmacological mechanisms. Biol Psychiatry. 1983;17:721–725.Google Scholar
23.Crammer, JL. Premenstrual depression, cortisol and oestradiol treatment. Psychol Med. 1986;16:451–455.CrossRefGoogle ScholarPubMed
24.Halbreich, U. Role of estrogen in depression of menopausal women. Proceedings of the X World Congress of Psychiatry. 1996:S–112–-S-1122.Google Scholar
25.Aronson, R, Offman, HJ, Joffe, RT, Naylor, CD. Tiiodothyronine augmentation in the treatment of refractory depression: a meta-analysis. Arch Gen Psychiatry. 1996;53:842–848.Google Scholar
26.Callahan, AM, Frye, MA, Marangell, LB, et al.Comparative antidepressant effects of intravenous and intrathecal thyrotropin-releasing hormone: confounding effects of tolerance and implications for therapeutics. Biol Psychiatry. 1997;41:264–272.Google Scholar
27.Van Bardeleben, V, Stalk, GK, Muller, OA, Holsboer, F. Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment. Biol Psychiatry. 1988;24:782–786.CrossRefGoogle Scholar
28.Holsboer, F. Psychiatric implications of altered limbichypothalamic-pituitary-adrenocortical activity. European Archives of Psychiatry and Neurological Sciences. 1989;238:302–322.CrossRefGoogle ScholarPubMed
29.Marchetti, B, Morale, MC, Gallo, F, et al.Neurochemical, immunological and pharmacological assessments in a transgenic mouse model of the endocrine changes in depression. Aging Clinical Experimentation Research. 1997;4(suppl):26–27.Google Scholar
30.Ader, R, Felten, DL, Cohen, N. Psychoneuroimmunology. San Diego, Calif: Academic Press Inc; 1991.Google Scholar
31.Wakstnan, BH. Immunological Mechanisms in Neurologic and Psychiatric Disease. New York, NY: Raven Press; 1990.Google Scholar
32.Glaser, R, Kiecolt-Glaser, J. Human Stress and Immunity. New York, NY: Academic Press; 1994.Google Scholar
33.Leonard, BE, Miller, K. Stress, the Immune System and Psychiatry. Chicester, England: Wiley; 1995.Google Scholar