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Repetitive TMS as a Probe of Mood In Health and Disease

Published online by Cambridge University Press:  07 November 2014

Mark S. George ,
Andrew M. Speer ,
Eric M. Wassermann ,
Timothy A. Kimbrell ,
Wendol A. William ,
Charles H. Kellner ,
S. Craig Risch ,
Laurie Stallings  and
Robert M. Post
Mark S. George
Affiliation:
Functional Neuroimaging Division, Psychiatry Department, MUSC Radiology Department, MUSC, Charleston, SC Human Motor Control Section, NINDS, NIH
Andrew M. Speer
Affiliation:
Functional Neuroimaging Division, Psychiatry Department, MUSC
Eric M. Wassermann
Affiliation:
Human Motor Control Section, NINDS, NIH
Timothy A. Kimbrell
Affiliation:
Biological Psychiatry Branch, NIMH, NIH
Wendol A. William
Affiliation:
NIAAA, NIH, Bethesda, MD
Charles H. Kellner
Affiliation:
Functional Neuroimaging Division, Psychiatry Department, MUSC
S. Craig Risch
Affiliation:
Functional Neuroimaging Division, Psychiatry Department, MUSC
Laurie Stallings
Affiliation:
Radiology Department, MUSC, Charleston, SC
Robert M. Post
Affiliation:
Biological Psychiatry Branch, NIMH, NIH
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Abstract

Recent advances in functional neuroimaging (including positron emission tomography, single-photon emission tomography, and fast magnetic resonance imaging) have allowed better understanding of the brain regions involved in regulating normal and pathological moods. Repetitive transcranial magnetic stimulation (rTMS) has the ability to stimulate or temporarily impair brain regions, which makes it a powerful tool for directly testing theories of the neurologic basis of mood regulation.

Type
Feature Articles
Information
CNS Spectrums , Volume 2 , Issue 1: Transcranial Magnetic Stimulation: Mapping & Modifying Brain-Behavior Relationships , January 1997 , pp. 39 - 44
Copyright
Copyright © Cambridge University Press 1997

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References

1.George, MS, Ketter, TA, Post, RM. What functional imaging studies have revealed about the brain basis of mood and emotion. In: Panksepp, J, ed. Advances in Biological Psychiatry. Greenwich, Conn: JAI Press; 1997:63–113.Google Scholar
2.Ketter, TA, George, MS, Kimbrell, TA, et al.Functional brain imaging, limbic function, and affective disorders. The Neuroscientist. 1996;2:55–65.Google Scholar
3.George, MS, Post, RM, Ketter, TA, et al.Neural mechanisms of mood disorders. Current Review of Mood and Anxiety Disorders. 1997;1:71–83.Google Scholar
4.George, MS, Ketter, TA, Post, RM. Prefrontal cortex dysfunction in clinical depression. Depression. 1994;2:59–72.Google Scholar
5.Nobler, MS, Sackeim, HA, Prohovnik, I, et al.Regional cerebral blood flow in mood disorders: III. treatment and clinical response. Arch Gen Psychiatry. 1994;51:884–897.Google Scholar
6.Baxter, LR Jr, Phelps, ME, Mazziotta, JC, et al.Cerebral metabolic rates for glucose in mood disorders: studies with positron emission tomography and fluorodeoxyglucose F 18. Arch Gen Psychiatry. 1985;42:441–447.CrossRefGoogle ScholarPubMed
7.Baxter, LR Jr, Schwartz, JM, Phelps, ME, et al.Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry. 1989;46:243–250.CrossRefGoogle ScholarPubMed
8.Andreason, PJ, Altemus, M, Zametkin, AJ, et al.Regional cerebral glucose metabolism in bulimia nervosa. Am J Psychiatry. 1992;149:1506–1513.Google Scholar
9.Drevets, WC, Videen, TO, Preskorn, SH, et al.A functional anatomical study of unipolar depression. J Neuroscience. 1992;12:3628–3641.Google Scholar
10.Stevens, JR, Mark, VH, Ervin, F, et al.Deep temporal stimulation in man. Arch Neurol. 1969;21:157.Google Scholar
11.Halgren, E, Walter, RD, Cherlow, DG, et al.Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala. Brain. 1978;101:83–117.Google Scholar
12.Heath, RG. Pleasure response of human subjects to direct stimulation of the brain: physiologic and psychodynamic considerations. In: Heath, RG, ed. The Role of Pleasure in Behavior. New York, NY: Paul B. Hoeber; 1964:219–243.Google Scholar
13.Penfield, W, Perot, P. The brain's record of auditory and visual experience: a final summary and discussion. Brain. 1963;86:595–696.CrossRefGoogle ScholarPubMed
14.Heath, RG. Activity of the human brain during emotional thought. In: Heath, RG, ed. The Role of Pleasure in Behavior. New York, NY: Paul B. Hoeber; 1994:Google Scholar
15.Heath, RG, Mickie, WA. Evaluation of seven years experience with depth electrode studies in human patients. In: Ramey, ER, O'Doherty, D, eds. Electrical Studies of the Unanesthetized Brain. New York, NY: Paul B. Hoeber, 1960:214–247.Google Scholar
16.Ketter, TA, Andreason, PJ, George, MS, Herscovitch, P, Post, RM. Paralimbic rCBF increases during procaine-induced psychosensory and emotional experiences. Biol Psychiatry. 1993;33:66A. [Abstract 107]Google Scholar
17.Kellner, CH, Post, RM, Putnam, F, et al.Intravenous procaine as a probe of limbic system activity in psychiatric patients and normal controls. Biol Psychiatry. 1987;22:1107–1126.Google Scholar
18.Parekh, PI, Spencer, JW, George, MS, et al.Procaine-induced increases in limbic rCBF correlate positively with increases in occipital and temporal EEG fast activity. Brain Topogr. 1995;7:209–216.CrossRefGoogle ScholarPubMed
19.Ketter, TA, Andreason, PJ, George, MS, et al.Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Arch Gen Psychiatry. 1996;53:59–69.Google Scholar
20.Papez, JW. A proposed mechanism of emotion. Arch Neurol Psychiatry. 1937;38:725–743.Google Scholar
21.Ketter, TA, Andreason, PJ, George, MS, Pazzaglia, PJ, Marangell, LM, Post, RM. Blunted CBF response to procaine in mood disorders. Presented at the American Psychiatric Association Annual Meeting; Philadelphia, PA. [134; Abstract NR297]Google Scholar
22.Trivedi, MH, Blackburn, T, Lewis, S, et al.Effects of amphetamine in major depressive disorder using functional MRI. Biol Psychiatry. 1995;37:657. Abstract.Google Scholar
23.Pardo, JV, Pardo, PJ, Raichle, ME. Neural correlates of self-induced dysphoria. Am J Psychiatry. 1993;150:713–719.Google ScholarPubMed
24.George, MS, Ketter, TA, Parekh, PI, et al.Brain activity during transient sadness and happiness in healthy women. Am J Psychiatry. 1995;152:341–351.Google Scholar
25.Ross, ED, Homan, RW, Buck, R. Differential hemispheric lateralization of primary and social emotions: implications for developing a comprehensive neurology for emotions, repression and the subconscious. Neuropsychiatry, Neuropsychology, and Behavioral Neurology. 1994;7:1–19.Google Scholar
26.Sackeim, HA, Greenberg, MS, Weiman, AL, et al.Hemispheric asymmetry in the expression of positive and negative emotions: neurologic evidence. Arch Neurol. 1982;39:210–218.Google Scholar
27.Sackeim, HA, Gur, RC. Lateral asymmetry in intensity of emotional expression. Neuropsychologia. 1978;163:473–481.Google Scholar
28.Sackeim, HA, Gur, RC, Saucy, MC. Emotions are expressed more intensely on the left side of the face. Science. 1978;202:434–436.Google Scholar
29.Wada, J, Rasmussen, T. Intracarotid injection of sodium amytal for the lateralization of cerebral speech dominance: experimental and clinical observations. J Neurosurg. 1960;17:266–282.Google Scholar
30.Christianson, SA, Saisa, J, Garvill, J, et al.Hemispheric inactivation and mood-state changes. Brain Cogn. 1993;23:127–144.Google Scholar
31.George, MS, Parekh, PI, Rosinsky, N, et al.Understanding emotional prosody activates right hemisphere regions. Arch Neurol. 1996;53:665–670.CrossRefGoogle ScholarPubMed
32.House, A, Dennis, M, Warlow, C, et al.Mood disorders after stroke and their relation to lesion location. Brain. 1990;113:1113–1129.Google Scholar
33.Sharpe, M, Hawton, K, House, A, et al.Mood disorders in long-term survivors of stroke: associations with brain lesion location and volume. Psychol Med. 1990;20:815–828.Google Scholar
34.Sackeim, HA. Emotion, disorders of mood, and hemispheric functional specialization. In: Carroll, BJ, Barrett, JE, eds. Psychopathology and the Brain. New York, NY: Raven Press; 1991:209–242.Google Scholar
35.George, MS, Wassermann, EM, Williams, W, et al.Changes in mood and hormone levels after rapid-rate transcranial magnetic stimulation of the prefrontal cortex. J Neuropsychiatry Clin Neurosci. 1996;8:172–180.Google Scholar
36.Pascual-Leone, A, Catala, MD, Pascual, AP. Lateralized effect of rapid-rate transcranial magnetic stimulation of the prefrontal cortex on mood. Neurology. 1996;46:499–502.CrossRefGoogle ScholarPubMed
37.Greenberg, BD, George, MS, Dearing, J, et al.Effect of repetitive transcranial magnetic stimulation on mood, anxiety and obsessive compulsive symptoms in OCD. APA New Research Program. 1995;191. [Abstract]Google Scholar
38.Hoflich, G, Kasper, S, Hufnagel, A, et al.Application of transcranial magnetic stimulation in treatment of drug-resistant major depression: a report of two cases. Human Psychopharmacology. 1993;8:361–365.CrossRefGoogle Scholar
39.Grisaru, N, Yarovslavsky, U, Abarbanel, J, et al.Transcranial magnetic stimulation in depression and schizophrenia. European Neuropsychopharmacology. 1994;4:287–288.Google Scholar
40.Kolbinger, HM, Hoflich, G, Hufnagel, A, et al.Transcranial magnetic stimulation (TMS) in the treatment of major depression: a pilot study. Human Psychopharmacology. 1995;10:305–310.Google Scholar
41.George, MS, Wassermann, EM. Rapid-rate transcranial magnetic stimulation (rTMS) and ECT. Convuls Ther. 1994;10:251–253.Google Scholar
42.George, MS, Wassermann, EM, Williams, WA, et al.Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. NeuroReport. 1995;6:1853–1856.Google Scholar
43.Pascual-Leone, A, Rubio, B, Pallardo, F, et al.Beneficial effect of rapid-rate transcranial magnetic stimulation of the left dorsolateral prefrontal cortex in drug-resistant depression. Lancet. 1996;347:233–237.Google Scholar
44.George, MS, Wassermann, EM, Williams, WA, et al. Daily left prefrontal rTMS in outpatient depression: initial results of a double-blind placebo controlled crossover trial. Presented at the American Psychiatric Association Annual Meeting, New York, 1996. [Abstract]Google Scholar
45.Wassermann, EM, Wang, B, Zeffiro, TA, et al.Locating the motor cortex on the MR1 with transcranial magnetic stimulation and PET. Neuroimage. 1996;1:1–9.Google Scholar
46.George, MS, Wassermann, EM, Kimbrell, T, et al.An overview of initial studies combining conventional functional imaging (PET, SPECT, fMRI) with transcranial magnetic stimulation (TMS) to actively probe brain-behavior relationships. J Neuropsychiatry Clin Neurosci. [Abstract]Google Scholar
47.Roberts, DR, Vincent, DJ, Speer, AM, et al.Multi-modality mapping of motor cortex: comparing echoplanar BOLD fMRI and transcranial magnetic stimulation. J Neural Transm. In press.Google Scholar
48.George, MS, Wassermann, EM, Post, RM. Transcranial magnetic stimulation: a neuropsychiatric tool for the 21st century. J Neuropsychiatry Clin Neurosci. 1996;8:373–382.Google Scholar