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Gene × Environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children

Published online by Cambridge University Press:  30 April 2013

John V. Lavigne ,
Laura B. K. Herzing ,
Edwin H. Cook ,
Susan A. Lebailly ,
Karen R. Gouze ,
Joyce Hopkins  and
Fred B. Bryant
John V. Lavigne*
Affiliation:
Northwestern University
Laura B. K. Herzing
Affiliation:
Northwestern University
Edwin H. Cook
Affiliation:
University of Illinois at Chicago
Susan A. Lebailly
Affiliation:
Northwestern University
Karen R. Gouze
Affiliation:
Northwestern University
Joyce Hopkins
Affiliation:
Illinois Institute of Technology
Fred B. Bryant
Affiliation:
Loyola University
*
Address correspondence and reprint requests to: John V. Lavigne, Department of Child and Adolescent Psychiatry, Children's Memorial Hospital (#10), 2300 Children's Plaza, Chicago, IL 60614; E-mail: jlavigne@childrensmemorial.org.
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Abstract

Genetic factors can play a key role in the multiple level of analyses approach to understanding the development of child psychopathology. The present study examined gene–environment correlations and Gene × Environment interactions for polymorphisms of three target genes, the serotonin transporter gene, the D4 dopamine receptor gene, and the monoamine oxidase A gene in relation to symptoms of anxiety, depression, and oppositional behavior. Saliva samples were collected from 175 non-Hispanic White, 4-year-old children. Psychosocial risk factors included socioeconomic status, life stress, caretaker depression, parental support, hostility, and scaffolding skills. In comparison with the short forms (s/s, s/l) of the serotonin transporter linked polymorphic repeat, the long form (l/l) was associated with greater increases in symptoms of oppositional defiant disorder in interaction with family stress and with greater increases in symptoms of child depression and anxiety in interaction with caretaker depression, family conflict, and socioeconomic status. In boys, low-activity monoamine oxidase A gene was associated with increases in child anxiety and depression in interaction with caretaker depression, hostility, family conflict, and family stress. The results highlight the important of gene–environment interplay in the development of symptoms of child psychopathology in young children.

Type
Regular Articles
Information
Development and Psychopathology , Volume 25 , Issue 2 , May 2013 , pp. 555 - 575
Copyright
Copyright © Cambridge University Press 2013

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