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Psychological, autonomic, and serotonergic correlates of parasuicide among adolescent girls

Published online by Cambridge University Press:  12 December 2005

SHEILA E. CROWELL ,
THEODORE P. BEAUCHAINE ,
ELIZABETH McCAULEY ,
CINDY J. SMITH ,
ADRIANNE L. STEVENS  and
PATRICK SYLVERS
SHEILA E. CROWELL
Affiliation:
University of Washington
THEODORE P. BEAUCHAINE
Affiliation:
University of Washington
ELIZABETH McCAULEY
Affiliation:
University of Washington
CINDY J. SMITH
Affiliation:
University of Washington
ADRIANNE L. STEVENS
Affiliation:
University of Washington
PATRICK SYLVERS
Affiliation:
University of Washington
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Abstract

Although parasuicidal behavior in adolescence is poorly understood, evidence suggests that it may be a developmental precursor of borderline personality disorder (BPD). Current theories of both parasuicide and BPD suggest that emotion dysregulation is the primary precipitant of self-injury, which serves to dampen overwhelmingly negative affect. To date, however, no studies have assessed endophenotypic markers of emotional responding among parasuicidal adolescents. In the present study, we compare parasuicidal adolescent girls (n = 23) with age-matched controls (n = 23) on both psychological and physiological measures of emotion regulation and psychopathology. Adolescents, parents, and teachers completed questionnaires assessing internalizing and externalizing psychopathology, substance use, trait affectivity, and histories of parasuicide. Psychophysiological measures including electrodermal responding (EDR), respiratory sinus arrhythmia, and cardiac pre-ejection period (PEP) were collected at baseline, during negative mood induction, and during recovery. Compared with controls, parasuicidal adolescents exhibited reduced respiratory sinus arrhythmia (RSA) at baseline, greater RSA reactivity during negative mood induction, and attenuated peripheral serotonin levels. No between-group differences on measures of PEP or EDR were found. These results lend further support to theories of emotion dysregulation and impulsivity in parasuicidal teenage girls.This work was supported by grants from the Seattle Children's Hospital and Regional Medical Center, the Pediatric Clinical Research Center at Seattle Children's Hospital (M01-RR 00037), and the National Foundation for Suicide Prevention to Cindy J. Smith, and by a grant from the National Institute of Mental Health to Theodore P. Beauchaine (R01 MH63699). We express thanks to Trevor Aerts, Anna Amen, Tyson Bailey, Jordan Campbell, Breyen Engelhardt, Ashleigh Freize, Jennifer Gross, Barbara Kleine, Dana Kovalchick, Jenna Lee, Eileen Magill, Elise Mallman, Emily Miller, Andrea Moore, Seamus Morrone, Shelby Soike, and Aubriana Teeley.

Type
Research Article
Information
Development and Psychopathology , Volume 17 , Issue 4 , December 2005 , pp. 1105 - 1127
Copyright
© 2005 Cambridge University Press

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References

REFERENCES

Achenbach, T. M. (1991a). Manual for the Child Behavior Checklist/4–18 and 1991 Profile. Burlington, VT: University of Vermont, Department of Psychiatry.
Achenbach, T. M. (1991b). Manual for the Teacher's Report Form and Profile. Burlington, VT: University of Vermont, Department of Psychiatry.
Achenbach, T. M. (1991c). Manual for the Youth Self-Report and Profile. Burlington, VT: University of Vermont, Department of Psychiatry.
Akselrod, S., Gordon, D., Ubel, F. A., Shannon, D. C., Barger, A. C., & Cohen, R. J. (1981). Power spectrum analysis of heart rate fluctuation: A quantitative of beat-to-beat cardiovascular control. Science 213, 220–222.Google Scholar
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders. Washington, DC: Author.
Angold, A., Costello, E. J., & Worthman, C. M. (1998). Puberty and depression: The role of age, pubertal status, and pubertal timing. Psychological Medicine 29, 1043–1053.Google Scholar
Apter, A., Gothelf, D., Orbach, I., Weizman, R., & Ratzoni, G. (1995). Correlation of suicidal and violent behavior in different diagnostic categories in hospitalized adolescent patients. Journal of the American Academy of Child and Adolescent Psychiatry 34, 912–918.Google Scholar
Asberg, M., Traskman, L., & Thoren, P. (1976). 5-HIAA in cerebrospinal fluid: A biochemical suicide predictor. Archives of General Psychiatry 33, 1193–1197.Google Scholar
Bagge, C., Nickell, A., Stepp, S., Durrett, C., Jackson, K., & Trull, T. J. (2004). Borderline personality disorder features predict negative outcomes 2 years later. Journal of Abnormal Psychology 113, 279–288.Google Scholar
Beauchaine, T. P. (2001). Vagal tone, development, and Gray's motivational theory: Toward an integrated model of autonomic nervous system functioning in psychopathology. Development and Psychopathology 13, 183–214.Google Scholar
Beauchaine, T. P., Gatzke–Kopp, L., & Mead, H. K. (in press). Polyvagal theory and developmental psychopathology: Emotion dysregulation and conduct problems from preschool to adolescence. Biological Psychology.
Beauchaine, T. P., Katkin, E. S., Strassberg, Z., & Snarr, J. (2001). Disinhibitory psychopathology in male adolescents: Discriminating conduct disorder from attention-deficit/hyperactivity disorder through concurrent assessment of multiple autonomic states. Journal of Abnormal Psychology 110, 610–624.Google Scholar
Beauchaine, T. P., & Marsh, P. (in press). Taxometric methods: Enhancing early detection and prevention of psychopathology by identifying latent vulnerability traits. In D. Cicchetti & D. Cohen (Eds.), Developmental psychopathology (2nd ed.). Hoboken, NJ: Wiley.
Beck, A. T., Steer, R. A., Sanderson, W. C., & Skeie, T. M. (1991). Panic disorder and suicidal ideation and behavior: Discrepant findings in psychiatric outpatients. American Journal of Psychiatry 148, 1195–1199.Google Scholar
Berntson, G. G., Bigger, T., Eckberg, D. L., Grossman, P., Kaufman, P. G., Malik, M., et al. (1997). Heart rate vatiability: Origins, methods, and interpretive caveats. Psychophysiology 34, 623–648.Google Scholar
Berridge, K. C., & Robinson, T. E. (2003). Parsing reward. Trends in Neuroscience 26, 507–513.Google Scholar
Birmaher, B., Ryan, N., Williamson, D. E., Brent, D. A., Kaufman, J., Dahl, R. E., et al. (1996). Childhood and adolescent depression: A review of the past 10 years. Part I. Journal of the American Academy of Child and Adolescent Psychiatry 35, 1427–1439.Google Scholar
Boergers, J., Spirito, A., & Donaldson, D. (1998). Reasons for adolescent suicide attempts. Journal of the American Academy of Child and Adolescent Psychiatry 37, 1287–1293.Google Scholar
Bongar, B. (2002). The suicidal patient: Clinical and legal standards of care (2nd ed.). Washington, DC: American Psychological Association.
Bostwick, J. M., & Pankratz, V. S. (2000). Affective disorders and suicide risk: A reexamination. American Journal of Psychiatry 157, 1925–1932.Google Scholar
Brenner, S. L., Beauchaine, T. P., & Sylvers, P. D. (2005). A comparison of psychophysiological and self report measures of BAS and BIS activation. Psychophysiology 42, 108–115.Google Scholar
Brent, D. A., Oquendo, M., Birmaher, B., Greenhill, L., Kolko, D., Stanley, B., et al. (2002). Familial pathways to early-onset suicide attempt: Risk for suicidal behavior in offspring of mood-disordered suicide attempters. Archives of General Psychiatry 59, 801–807.Google Scholar
Brodsky, B. S., Oquendo, M., Ellis, S., Haas, G. L., Malone, K. M., & Mann, J. J. (2001). The relationship of childhood abuse to impulsivity and suicidal behavior in adults with major depression. American Journal of Psychiatry 158, 1871–1877.Google Scholar
Brown, M. Z., Comtois, K. A., & Linehan, M. M. (2002). Reasons for suicide attempts and nonsuicidal self-injury in women with borderline personality disorder. Journal of Abnormal Psychology 111, 198–202.Google Scholar
Bush, G., Frazier, J. A., Rausch, S. L., Seidman, L. J., Walen, P. J., Jenike, N. A., et al. (1999). Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting Stroop. Biological Psychiatry 45, 1542–1552.Google Scholar
Calkins, S. D., & Dedmon, S. E. (2000). Physiological and behavioral regulation in two-year-old children with aggressive/destructive behavior problems. Journal of Abnormal Child Psychology 28, 103–118.Google Scholar
Carr, E. G. (1977). The motivation for self-injurious behavior: A review of some hypotheses. Psychological Bulletin 84, 800–816.Google Scholar
Castellanos, F. X., & Tannock, R. (2002). Neuroscience of attention-deficit/hyperactivity disorder: The search for endophenotypes. Neuroscience: Nature Reviews 3, 617–628.Google Scholar
Cicchetti, D. (1990). A historical perspective on the discipline of developmental psychopathology. In J. Rolf, A. S. Masten, D. Cicchetti, K. H. Nuechterlein, & S. Weintraub (Eds.), Risk and protective factors in the development of psychopathology (pp. 2–28). New York: Cambridge University Press.
Cicchetti, D., Ackerman, B. P., & Izard, C. E. (1995). Emotions and emotion regulation in developmental psychopathology. Development and Psychopathology 7, 1–10.Google Scholar
Cicchetti, D., & Cannon, T. D. (1999). Neurodevelopmental processes in the ontogenesis and epigenesis of psychopathology. Development and Psychopathology 11, 375–393.Google Scholar
Cicchetti, D., Ganiban, J., & Barnett, D. (1991). Contributions from the study of high-risk populations to understanding the development of emotional regulation. In J. Garber & K. A. Dodge (Eds.), The development of emotion regulation and dysregulation (pp. 69–88). Cambridge: Cambridge University Press.
Cicchetti, D., & Rogosch, F. A. (2002). A developmental psychopathology perspective on adolescence. Journal of Consulting and Clinical Psychology 70, 6–20.Google Scholar
Cloninger, C. R., Svrakic, N. M., & Svrakic, D. M. (1997). Role of personality self-organization in development of mental order and disorder. Development and Psychopathology 9, 881–906.Google Scholar
Cole, D. A., Truglio, R., & Peeke, L. (1997). Relation between symptoms of anxiety and depression in children: A multitrait–multimethod assessment. Journal of Consulting and Clinical Psychology 65, 110–119.Google Scholar
Cole, P. M., Martin, S. E., & Dennis, T. A. (2004). Emotion regulation as a scientific construct: Methodological challenges and directions for child development research. Child Development 75, 317–333.Google Scholar
Cole, P. M., Michel, M. K., & Teti, L. O. (1994). The development of emotion regulation and dysregulation: A clinical perspective. Monographs of the Society for Research in Child Development 59(Serial No. 240), 73–100.Google Scholar
Cole, P. M., Teti, L. O., & Zahn–Waxler, C. (2003). Mutual emotion regulation and the stability of conduct problems between preschool and early school age. Development and Psychopathology 30, 1–18.Google Scholar
Comtois, K. A. (2002). A review of interventions to reduce the prevalence of parasuicide. Psychiatric Services 53, 1138–1144.Google Scholar
Corr, P. J. (2004). Reinforcement sensitivity theory and personality. Neuroscience and Biobehavioral Reviews 28, 317–332.Google Scholar
Cox, B. J., Direnfeld, D. M., Swinson, R. P., & Norton, G. R. (1994). Suicidal ideation and suicide attempts in panic disorder and social phobia. American Journal of Psychiatry 151, 882–887.Google Scholar
Cremniter, D., Jamain, S., Kollenbach, K., Alvarez, J.-C., Lecrubier, Y., Gilton, A., et al. (1999). CSF 5-HIAA levels are lower in impulsive as compared to nonimpulsive violent suicide attempters and control subjects. Biological Psychiatry 45, 1572–1579.Google Scholar
Crowell, S. E., Beauchaine, T. P., Sylvers, P. D., Mead, H., & Gatzke–Kopp, L. (in press). Autonomic correlates of attention-deficit/hyperactivity disorder and oppositional defiant disorder in preschool children. Journal of Abnormal Psychology.
Dahl, R. E. (2001). Affect regulation, brain development, and behavioral/emotional health in adolescence. CNS Spectrums 6, 1–12.Google Scholar
Davidson, R. J. (2000). Affective style, psychopathology, and resilience: Brain mechanisms and placticity. American Psychologist 55, 1196–1214.Google Scholar
Depue, R. A., & Lenzenweger, M. F. (2005). A neurobehavioral dimensional model of personality disturbance. In M. F. Lenzenweger & J. F. Clarkin (Eds.), Major theories of personality disorder (2nd ed., pp. 391–454). New York: Guilford Press.
Dodge, K. (1991). Emotion and social information processing. In J. Garber & K. A. Dodge (Eds.), The development of emotion regulation and dysregulation (pp. 159–181). Cambridge: Cambridge University Press.
Dumas, J. E., LaFreniere, P. J., & Serketich, W. J. (1995). “Balance of power“: A transactional analysis of control in mother–child dyads involving socially competent, aggressive, and anxious children. Journal of Abnormal Psychology 104, 104–113.Google Scholar
Edman, G., Asberg, M., Levander, S., & Shalling, W. (1986). Skin conductance level, habituation, cerebrospinal fluid 5-hydroxiindole acetic acid in suicidal patients. Archives of General Psychiatry 43, 586–592.Google Scholar
Enns, M. W., Cox, B. J., & Inayatulla, M. (2003). Personality predictors of outcome for adolescents hospitalized for suicidal ideation. Journal of the American Academy of Child and Adolescent Psychiatry 42, 720–727.Google Scholar
Esposito, C., Spirito, A., Boergers, J., & Donaldson, D. (2003). Affective, behavioral, and cognitive functioning in adolescents with multiple suicide attempts. Suicide and Life-Threatening Behavior 33, 389–399.Google Scholar
Fawcett, J. (1992). Suicide risk factor in depressive disorders and in panic disorder. Journal of Clinical Psychiatry 53, 9–13.Google Scholar
Fawcett, J., Scheftner, W., Fogg, L., Clark, D. C., Young, M. A., Hedecker, D., et al. (1990). Time-related predictors of suicide in major affective disorder. American Journal of Psychiatry 147, 1189–1194.Google Scholar
Feldman, R., Greenbaum, C. W., & Yirmiya, N. (1999). Mother–infant affect synchrony as an antecedent of the emergence of self-control. Developmental Psychopathology 35, 223–231.Google Scholar
Foster, T., Gillespie, K., & McClelland, R. (1997). Mental disorders and suicide in Northern Ireland. British Journal of Psychiatry 170, 447–452.Google Scholar
Fowles, D. C. (1980). The true arousal model: Implications of Gray's two-factor learning theory for heart rate, electrodermal activity, and psychopathy. Psychophysiology 17, 87–104.Google Scholar
Fowles, D. C. (1988). Psychophysiology and psychopathology: A motivational approach. Psychophysiology 25, 373–391.Google Scholar
Fowles, D. C. (2000). Electrodermal hyporeactivity and antisocial behavior: Does anxiety mediate the relationship? Journal of Affective Disorders 61, 177–189.Google Scholar
Fox, N. A. (1994). Dynamic cerebral processes underlying emotion regulation. Monographs of the Society for Research in Child Development 59(Serial No. 240), 152–166.Google Scholar
Fox, N. A., & Calkins, S. D. (2003). The development of self-control of emotion: Intrinsic and extrinsic influences. Motivation and Emotion 27, 7–26.Google Scholar
Fox, N. A., & Henderson, H. A. (2001). Continuity and discontinuity of behavioral inhibition and exuberance: Psychophysiological and behavioral influences across the first four years of life. Child Development 72, 1–21.Google Scholar
Gadow, K. D., Sprafkin, J., Carlson, G., Schneider, J., Nolan, E. E., Mattison, R. E., et al. (2002). A DSM-IV-referenced adolescent self-report rating scale. Journal of the American Academy of Child and Adolescent Psychiatry 41, 671–679.Google Scholar
Gatzke–Kopp, L., & Beauchaine, T. P. (in press). Central nervous system substrates of impulsivity: Implications for the development of attention-deficit/hyperactivity disorder and conduct disorder. In D. Coch, G. Dawson, & K. Fischer (Eds.), Human behavior and the developing brain: Atypical development. New York: Guilford Press.
Gatzke–Kopp, L. M., Raine, A., Loeber, R., Stouthamer–Loeber, M., & Steinhauer, S. R. (2002). Serious delinquent behavior, sensation seeking, and electrodermal arousal. Journal of Abnormal Child Psychology 30, 477–486.Google Scholar
Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., et al. (1999). Brain development during childhood and adolescence: A longitudinal MRI study. Nature Neuroscience 2, 861–863.Google Scholar
Goldman, S. J., D'Angelo, E. J., & DeMaso, D. R. (1993). Psychopathology in the families of children and adolescents with borderline personality disorder. American Journal of Psychiatry 150, 1832–1835.Google Scholar
Gould, M. S., Greenberg, T., Velting, D. M., & Shaffer, D. (2003). Youth suicide risk and preventive interventions: A review of the past 10 years. Journal of the American Academy of Child and Adolescent Psychiatry 42, 386–405.Google Scholar
Gray, J. A., & McNaughton, N. (2000). The neuropsychology of anxiety. Oxford: Oxford University Press.
Gross, J. J., & Levenson, R. W. (1995). Emotion elicitation using films. Cognition and Emotion 9, 87–108.Google Scholar
Grunbaum, J. A., Kann, L., Kinchen, S. A., Williams, B., Ross, J. G., Lowry, R., et al. (2002). Youth risk behavior surveillance—United States 2001. MMWR Surveillance Summaries 51, 1–64.Google Scholar
Gunnell, D., & Frankel, S. (1994). Prevention of suicide: Aspirations and evidence. British Medical Journal, 308, 6938.Google Scholar
Haines, J., Williams, C. L., Brain, K. L., & Wilson, G. V. (1995). The psychophysiology of self-mutilation. Journal of Abnormal Psychology 104, 471–489.Google Scholar
Haw, C., Hawton, K., Houston, K., & Townsend, E. (2001). Psychiatric and personality disorders in deliberate self-harm patients. British Journal of Psychiatry 178, 48–54.Google Scholar
Hawton, K., Haw, C., Houston, K., & Townsend, E. (2002). Family history of suicidal behaviour: Prevalence and significance in deliberate self-harm patients. Acta Psychiatrica Scandinavica 103, 387–393.Google Scholar
Henderson, H. A., Fox, N. A., & Rubin, K. H. (2001). Temperamental contributions to social behavior. The moderating roles of frontal EEG asymmetry and gender. Journal of the American Academy of Child and Adolescent Psychiatry 40, 68–74.Google Scholar
Herpertz, S. C., Dietrich, T. M., Wenning, B., Krings, T., Erberich, S. G., Willmes, K., et al. (2001). Evidence of abnormal amygdala functioning in borderline personality disorder: A functional MRI study. Biological Psychiatry 50, 292–298.Google Scholar
Herpertz, S. C., Kunert, H. J., Schwenger, U. B., & Sass, H. (1999). Affective responsiveness in borderline personality disorder: A psychophysiological approach. American Journal of Psychiatry 156, 1550–1556.Google Scholar
Irwin, H. J. (1994). Proneness to dissociation and traumatic childhood events. Journal of Nervous and Mental Disease 182, 456–460.Google Scholar
Joiner, T. E., Johnson, F., & Soderstrom, K. (2002). Association between serotonin transporter gene polymorphism and family history of attempted and completed suicide. Suicide and Life-Threatening Behavior 32, 329–332.Google Scholar
Kagan, J. (1999). The concept of behavioral inhibition. In L. A. Schmidt & J. Schulkin (Eds.), Extreme fear, shyness, and social phobia: Origins, biological mechanisms, and clinical outcomes. Series in affective science (pp. 3–13). New York: Oxford University Press.
Kamali, M., Oquendo, M. A., & Mann, J. J. (2002). Understanding the neurobiology of suicidal behavior. Depression and Anxiety 14, 164–176.Google Scholar
Katkin, E. (1965). Relationship between manifest anxiety and two indices of autonomic response to stress. Journal of Personality and Social Psychology 2, 324–333.Google Scholar
Katz, L. Y., Cox, B. J., Gunasekara, S., & Miller, A. L. (2004). Feasibility of dialectical behavior therapy for suicidal adolescent inpatients. Journal of the American Academy of Child and Adolescent Psychiatry 43, 276–282.Google Scholar
Katz, L. Y., Gunasekara, S., & Miller, A. L. (2002). Dialectical behavior therapy for inpatient and outpatient parasuicidal adolescents. In L. T. Flaherty (Ed.), The Annals of the American Society for Adolescent Psychiatry (pp. 116–178). Hillsdale, NJ: Analytic Press.
Keilp, J. G., Sackeim, H. A., Brodsky, B. S., Oquendo, M. A., Malone, K. M., & Mann, J. J. (2001). Neuropsychological dysfunction in depressed suicide attempters. American Journal of Psychiatry 158, 735–741.Google Scholar
Kelsey, R. M., & Guethlein, W. (1990). An evaluation of the ensemble averaged impedance cardiogram. Psychophysiology 27, 24–33.Google Scholar
Kienhorst, I. C. W. M., De Wilde, E. J., Diekstra, R. F. W., & Wolters, W. H. G. (1995). Adolescents' image of their suicide attempt. Journal of the American Academy of Child and Adolescent Psychiatry 34, 623–628.Google Scholar
Kingsbury, S., Hawton, K., Steinhardt, K., & James, A. (1999). Do adolescents who take overdoses have specific psychological characteristics? A comparative study with psychiatric and community controls. Journal of the American Academy of Child and Adolescent Psychiatry 38, 1125–1131.Google Scholar
Korfine, L., & Hooley, J. M. (2000). Directed forgetting of emotional stimuli in borderline personality disorder. Journal of Abnormal Psychology 109, 214–221.Google Scholar
Kovacs, M. (1992). Children's Depression Inventory. Niagara Falls, NY: Multi-Health Systems.
Kreitman, N. (1977). Parasuicide. London: Wiley.
Kupper, N., Willemsen, G., Posthuma, D., de Boer, D., Boomsma, D. I., & de Geus, E. J. C. (2004). Genetic and environmental contribution to ambulatory heart period, respiration rate, respiratory sinus arrhythmia, and their covariance. Manuscript submitted for publication.
Lepine, J. P., Chignon, J. M., & Teherani, M. (1993). Suicide attempts in patients with panic disorder. Archives of General Psychiatry 50, 144–149.Google Scholar
Lindstrom, M. B., Ryding, E., Bosson, P., Ahnlide, J.-A., Rosen, I., & Traskman–Bendz, L. (2004). Impulsivity related to brain serotonin transporter binding capacity in suicide attempters. European Neuropsychopharmacology 14, 295–300.Google Scholar
Linehan, M. (1993). Cognitive–behavioral treatment of borderline personality disorder. New York: Guilford Press.
Linehan, M., & Comtois, K. A. (1996). Lifetime Parasuicide Count. Unpublished manuscript.
Lorber, M. F. (2004). Psychophysiology of aggression, psychopathy, and conduct problems: A meta-analysis. Psychological Bulletin 130, 531–552.Google Scholar
Macfie, J., Cicchetti, D., & Toth, S. L. (2001). The development of dissociation in maltreated preschool-aged children. Development and Psychopathology 13, 233–254.Google Scholar
Mann, J. J., Waternaux, C., Haas, G. L., & Malone, K. M. (1999). Toward a clinical model of suicidal behavior in psychiatric patients. American Journal of Psychiatry 156, 181–189.Google Scholar
Maser, J. D., Akiskal, H. S., Schettler, P., Scheftner, W., Mueller, T., Endicott, J., et al. (2002). Can temperament identify affectively ill patients who engage in lethal or near-lethal suicidal behavior? A 14-year prospective study. Suicide and Life-Threatening Behavior 32, 10–32.Google Scholar
McCubbin, J. A., Richardson, J. E., Langer, A. W., Kizer, J. S., & Obrist, P. A. (1983). Sympathetic neuronal function and left ventricular performance during behavioral stress in humans: The relationship between plasma catecholamines and systolic time intervals. Psychophysiology 20, 102–110.Google Scholar
McGee, R., Williams, S., & Nada–Raja, S. (2001). Low self-esteem and hopelessness in childhood and suicidal ideation and early adulthood. Journal of Abnormal Child Psychology 29, 281–291.Google Scholar
Meyer, J. H., McMain, S., Kennedy, S. H., Korman, L., Brown, G. M., DaSilva, J. N., et al. (2003). Dysfunctional attitudes and 5-HT 2 receptors during depression and self-harm. American Journal of Psychiatry 160, 90–99.Google Scholar
Negron, R., Piacentini, J., Graae, F., Davies, M., & Shaffer, D. (1997). Microanalysis of adolescent suicide attempters and ideators during the acute suicidal episode. Journal of the American Academy of Child and Adolescent Psychiatry 36, 1512–1519.Google Scholar
Nixon, M. K., Cloutier, P. F., & Aggarwal, S. (2002). Affect regulation and addictive aspects of repetitive self-injury in hospitalized adolescents. Journal of the American Academy of Child and Adolescent Psychiatry 41, 1333–1341.Google Scholar
Norden, K. A., Klein, D. N., Donaldson, S. K., Pepper, C. M., & Klein, L. M. (1995). Reports of the early home environment in DSM-III-R personality disorders. Journal of Personality Disorders 9, 213–223.Google Scholar
Noyes, R. (1991). Suicide and panic disorder: A review. Journal of Affective Disorders 22, 1–11.Google Scholar
Ohring, R., Apter, A., Ratazoni, G., Weizman, R., Tyano, S., & Plutchick, R. (1996). State and trait anxiety in adolescent suicide attempters. Journal of the American Academy of Child and Adolescent Psychiatry 35, 154–157.Google Scholar
Overbeek, T., Rikken, J., Schuers, K., & Griez, E. (1998). Suicidal ideation in panic disorder patients. Journal of Nervous and Mental Disease 186, 577–580.Google Scholar
Overholser, J. C., Adams, D. M., Lehnert, K. L., & Brinkman, D. C. (1995). Self-esteem deficits and suicidal tendencies among adolescents. Journal of the American Academy of Child and Adolescent Psychiatry 34, 919–928.Google Scholar
Pandey, G. N., Dwivedi, Y., Rizavi, H. S., Ren, X., Pandey, S. C., Pesold, C., et al. (2002). Higher expression of serotonin 5-HT 2a receptors in the postmortem brains of teenage suicide victims. American Journal of Psychiatry 159, 419–429.Google Scholar
Paris, J. (1997). Antisocial and borderline personality disorders: Two separate diagnoses or two aspects of the same psychopathology. Comprehensive Psychiatry 38, 237–242.Google Scholar
Patterson, G. R. (1982). Coercive family process. Eugene, OR: Castalia.
Perez–Edgar, K., & Fox, N. A. (2005). A behavioral and electrophysiological study of children's selective attention under neutral and affective conditions. Journal of Cognition and Development 6, 89–118.Google Scholar
Pilowsky, D. J., Wu, L., & Anthony, J. C. (1999). Panic attacks and suicide attempts in mid-adolescence. American Journal of Psychiatry 156, 1545–1549.Google Scholar
Pollak, S. D. (2003). Experience-dependent affective learning and risk for psychopathology in children. Annals New York Academy of Sciences 1008, 102–111.Google Scholar
Pollak, S. D., Klorman, R., Brumaghim, J., & Cicchetti, D. (2001). P3b reflects maltreated children's reactions to facial displays of emotion. Psychophysiology 38, 267–274.Google Scholar
Porges, S. W. (1995). Orienting in a defensive world: Mammalian modifications of our evolutionary heritage. A polyvagal theory. Psychophysiology 32, 301–318.Google Scholar
Porges, S. W. (1997). Emotion: An evolutionary by-product of the neural regulation of the autonomic nervous system. Annals New York Academy of Sciences 807, 62–77.Google Scholar
Porges, S. W. (2001). The polyvagal theory: Phylogenetic substrates of a social nervous system. International Journal of Psychophysiology 42, 123–146.Google Scholar
Putnam, F. W., (1993). Dissociative disorders in children: Behavioral profiles and problems. Child Abuse and Neglect 17, 39–45.Google Scholar
Qu, M., Zhang, Y., Webster, J. G., & Tompkins, W. J. (1986). Motion artifact from spot and band electrodes during impedance cardiography. IEEE Transactions on Biomedical Engineering 33, 1029–1036.Google Scholar
Quay, H. C. (1993). The psychobiology of undersocialized aggressive conduct disorder: A theoretical perspective. Development and Psychopathology 5, 165–180.Google Scholar
Rathus, J. H., & Miller, A. L. (2002). Dialectical behavior therapy adapted for suicidal adolescents. Suicide and Life-Threatening Behavior 32, 146–157.Google Scholar
Rodham, K., Hawton, K., & Evans, E. (2004). Reasons for deliberate self-harm: Comparison of self-poisoners and self-cutters in a community sample of adolescents. Journal of the American Academy of Child and Adolescent Psychiatry 43, 80–87.Google Scholar
Rotheram–Borus, M. J., Trautman, P. D., Dopkins, S. C., & Shrout, P. E. (1990). Cognitive style and pleasant activities among female adolescent suicide attempters. Journal of Consulting and Clinical Psychology 58, 554–561.Google Scholar
Rottenberg, J., Wilhelm, F. H., Gross, J. J., & Gotlib, I. H. (2002). Respiratory sinus arrhythmia as a predictor of outcome in major depressive disorder. Journal of Affective Disorders 71, 265–272.Google Scholar
Rudd, M. D., Joiner, T., & Rajab, M. H. (1996). Relationships among suicide ideators, attempters, and multiple attempters in a young adult sample. Journal of Abnormal Psychology 105, 541–550.Google Scholar
Rudd, M. D., Joiner, T. F., & Rumzek, H. (2004). Childhood diagnoses and later risk for multiple suicide attempts. Suicide and Life-Threatening Behavior 34, 113–125.Google Scholar
Rutter, M., & Sroufe, L. A. (2000). Developmental psycopathology: Concepts and challenges. Development and Psychopathology 12, 265–296.Google Scholar
Sagvolden, T., Johansen, E. B., Aase, H., & Russell, V. A. (in press). A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) primarily hyperactive/impulsive and combined subtypes. Behavioral and Brain Sciences.
Shaffer, D., Gould, M. S., Fisher, P., Trautman, P., Moreau, D., Kleinman, M., et al. (1996). Psychiatric diagnosis in child and adolescent suicide. Archives of General Psychiatry 53, 339–348.Google Scholar
Sherwood, A., Allen, M. T., Fahrenberg, J., Kelsey, R. M., Lovallo, W. R., & van Doornen, L. J. P. (1990). Committee report: Methodological guidelines for impedance cardiography. Psychophysiology 27, 1–23.Google Scholar
Sherwood, A., Allen, M. T., Obrist, P. A., & Langer, A. W. (1986). Evaluation of beta-adrenergic influences on cardiovascular and metabolic adjustments to physical and psychological stress. Psychophysiology 23, 89–104.Google Scholar
Snyder, J., Edwards, P., McGraw, K., Kilgore, K., & Holton, A. (1994). Escalation and reinforcement in mother–child conflict: Social processes associated with the development of physical aggression. Development and Psychopathology 6, 305–321.Google Scholar
Snyder, J., Schrepferman, L., & St. Peter, C. (1997). Origins of antisocial behavior: Negative reinforcement and affect dysregulation of behavior as socialization mechanisms in family interaction. Behavior Modification 21, 187–215.Google Scholar
Sroufe, L. A., & Rutter, M. (1984). The domain of developmental psychopathology. Child Development 55, 17–29.Google Scholar
Steinberg, L., Dahl, R., Keating, D., Kupfer, D. J., Masten, A. S., & Pine, D. (in press). The study of developmental psychopathology in adolescence: Integrating affective neuroscience with the study of context. In D. Cicchetti & D. Cohen (Eds.), Handbook of developmental psychopathology (2nd ed.). New York: Wiley.
U.S. Public Health Service. (1999). The surgeon general's call to action to prevent suicide. Washington, DC: Author.
Valentiner, D. P., Gutierrez, P. M., & Blacker, D. (2002). Anxiety measures and their relationship to adolescent suicidal ideation and behavior. Anxiety Disorders 16, 11–32.Google Scholar
Valliant, G. E. (1975). Sociopathy as a human process. Archives of General Psychiatry 32, 178–183.Google Scholar
van Heeringen, C., Audenaert, K., Van Laere, K., Dumont, F., Slegers, G., Mertens, J., et al. (2003). Prefrontal 5-HT receptor binding index, hopelessness and personality characteristics in attempted suicide. Journal of Affective Disorders 74, 149–158.Google Scholar
Vaidya, C. J., Austin, G., Kirkorian, G., Ridlehuber, H. W., Desmond, J. E., Glover, G. H., et al. (1998). Selective effects of methylphenidate in attention deficit hyperactivity disorder: A functional magnetic resonance study. Proceedings of the National Academy of Sciences 95, 14494–14499.Google Scholar
van den Buuse, M. (1998). Role of the mesolimbic dopamine system in cardiovascular homeostasis: Stimulation of the ventral tegmental area modulates the effect of vasopressin in conscious rats. Clinical Experimental Pharmacology and Physiology 25, 661–668.Google Scholar
Vasey, M. W., & Thayer, J. F. (1987). The continuing problem of false positives in repeated measures ANOVA in psychophysiology: A multivariate solution. Psychophysiology 24, 479–486.Google Scholar
Vaughn, B. E., Kopp, C. B., & Krakow, J. B. (1984). The emergence and consolidation of self-control from eighteen to thirty months of age: Normative trends and individual differences. Child Development 55, 990–1004.Google Scholar
Vickers, K., & McNally, R. J. (2004). Panic disorder and suicide attempt in the national comorbidity survey. Journal of Abnormal Psychology 113, 582–591.Google Scholar
Wagner, A. W., & Linehan, M. M. (1999). Facial expression recognition ability among women with borderline personality disorder: Implications for emotion regulation? Journal of Personality Disorders 13, 329–344.Google Scholar
Warshaw, M. G., Dolan, R. T., & Keller, M. B. (2000). Suicidal behavior in patients with current or past panic disorder: Five years of prospective data from the Harvard/Brown Anxiety Research Program. American Journal of Psychiatry 157, 1876–1878.Google Scholar
Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: The PANAS scales. Journal of Personality and Social Psychology 54, 1063–1070.Google Scholar
Weissman, M. M. (1991). Panic disorder: Impact on quality of life. Journal of Clinical Psychiatry 52, 6–8.Google Scholar
Weissman, M. M., Bland, R. C., Canino, G. J., Greenwald, S., Lee, C. K., Newman, S. C., et al. (1996). The cross-national epidemiology of social phobia: A preliminary report. International Clinical Psychopharmacology 11, 9–14.Google Scholar
Weissman, M. M., Klerman, G. L., Markowitz, J., & Ouellette, R. (1989). Suicide ideation and attempts in panic disorder. New England Journal of Medicine 321, 1209–1214.Google Scholar
Wolfersdorf, M., & Straub, R. (1993). Electrodermal activity in depressive men and women with violent and non-violent suicide attempts. Schweizer Archiv fur Neurologie und Psychiatrie 144, 173–184.Google Scholar
Wolfersdorf, M., & Straub, R. (1994). Electrodermal reactivity in male and female depressive patients who later died by suicide. Acta Psychiatrica Scandinavica 89, 279–284.Google Scholar
Wolfersdorf, M., Straub, R., Barg, T., Keller, F., & Kaschka, W. P. (1999). Depressed inpatients, electrodermal reactivity, and suicide—A study about psychophysiology of suicidal behavior. Archives of Suicide Research 5, 1–10.Google Scholar
World Health Organization. (2002). World report on violence and health. Geneva: Author.
Yochelson, S., & Samenow, S. (1976). The criminal personality. New York: Aronson.
Zlotnick, C., Donaldson, D., Spirito, A., & Pearlstein, T. (1997). Affect regulation and suicide attempts in adolescent inpatients. Journal of the American Academy of Child and Adolescent Psychiatry 36, 793–798.Google Scholar