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Reciprocal social behavior in youths with psychotic illness and those at clinical high risk

Published online by Cambridge University Press:  08 November 2013

Maria Jalbrzikowski
Affiliation:
University of California, Los Angeles
Kate E. Krasileva
Affiliation:
University of California, Los Angeles
Sarah Marvin
Affiliation:
University of California, Los Angeles
Jamie Zinberg
Affiliation:
University of California, Los Angeles
Angielette Andaya
Affiliation:
University of California, Los Angeles
Peter Bachman
Affiliation:
University of California, Los Angeles
Tyrone D. Cannon
Affiliation:
University of California, Los Angeles
Carrie E. Bearden*
Affiliation:
University of California, Los Angeles
*
Address correspondence and reprint requests to: Carrie E. Bearden, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Box 956968, 300 Medical Plaza, Room 2267, Los Angeles, CA 90095-6968; E-mail: cbearden@mednet.ucla.edu.

Abstract

Youths at clinical high risk (CHR) for psychosis typically exhibit significant social dysfunction. However, the specific social behaviors associated with psychosis risk have not been well characterized. We administer the Social Responsiveness Scale (SRS), a measure of autistic traits that examines reciprocal social behavior, to the parents of 117 adolescents (61 CHR individuals, 20 age-matched adolescents with a psychotic disorder [AOP], and 36 healthy controls) participating in a longitudinal study of psychosis risk. AOP and CHR individuals have significantly elevated SRS scores relative to healthy controls, indicating more severe social deficits. Mean scores for AOP and CHR youths are typical of scores obtained in individuals with high functioning autism (Constantino & Gruber, 2005). SRS scores are significantly associated with concurrent real-world social functioning in both clinical groups. Finally, baseline SRS scores significantly predict social functioning at follow-up (an average of 7.2 months later) in CHR individuals, over and above baseline social functioning measures (p < .009). These findings provide novel information regarding impairments in domains critical for adolescent social development, because CHR individuals and those with overt psychosis show marked deficits in reciprocal social behavior. Further, the SRS predicts subsequent real-world social functioning in CHR youth, suggesting that this measure may be useful for identifying targets of treatment in psychosocial interventions.

Type
Regular Articles
Copyright
Copyright © Cambridge University Press 2013 

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References

Addington, J., Cornblatt, B. A., Cadenhead, K. S., Cannon, T. D., McGlashan, T. H., Perkins, D. O., et al. (2011). At clinical high risk for psychosis: Outcome for nonconverters. American Journal of Psychiatry, 168, 800805.CrossRefGoogle ScholarPubMed
Addington, J., Penn, D., Woods, S. W., Addington, D., & Perkins, D. O. (2008). Social functioning in individuals at clinical high risk for psychosis. Schizophrenia Research, 99, 119124.Google Scholar
Bengtsson-Tops, A., & Hansson, L. (2001). Quantitative and qualitative aspects of the social network in schizophrenic patients living in the community: Relationship to sociodemographic characteristics and clinical factors and subjective quality of life. International Journal of Social Psychiatry, 47, 6777.Google Scholar
Birchwood, M., Smith, J., Cochrane, R., Wetton, S., & Copestake, S. (1990). The Social Functioning Scale: The development and validation of a new scale of social adjustment for use in family intervention programmes with schizophrenic patients. British Journal of Psychiatry, 157, 853859.Google Scholar
Bowie, C. R., Reichenberg, A., Patterson, T. L., Heaton, R. K., & Harvey, P. D. (2006). Determinants of real-world functional performance in schizophrenia subjects: Correlations with cognition, functional capacity, and symptoms. American Journal of Psychiatry, 163, 418425.Google Scholar
Cannon, M., Jones, P., Gilvarry, C., Rifkin, L., McKenzie, K., Foerster, A., et al. (1997). Premorbid social functioning in schizophrenia and bipolar disorder: Similarities and differences. American Journal of Psychiatry, 154, 15441550.Google ScholarPubMed
Cannon, T. D., Cadenhead, K., Cornblatt, B., Woods, S. W., Addington, J., Walker, E., et al. (2008). Prediction of psychosis in youth at high clinical risk: A multisite longitudinal study in North America. Archives of General Psychiatry, 65, 2837.CrossRefGoogle ScholarPubMed
Constantino, J. N., Abbacchi, A. M., Lavesser, P. D., Reed, H., Givens, L., Chiang, L., et al. (2009). Developmental course of autistic social impairment in males. Development and Psychopathology, 21, 127138.Google Scholar
Constantino, J. N., Davis, S. A., Todd, R. D., Schindler, M. K., Gross, M. M., Brophy, S. L., et al. (2003). Validation of a brief quantitative measure of autistic traits: Comparison of the Social Responsiveness Scale with the Autism Diagnostic Interview—Revised. Journal of Autism and Developmental Disorders, 33, 427433.Google Scholar
Constantino, J. N., & Gruber, C. P. (2005). Social Responsiveness Scale (SRS). Los Angeles: Western Psychological Services.Google Scholar
Constantino, J. N., Przybeck, T., Friesen, D., & Todd, R. D. (2000). Reciprocal social behavior in children with and without pervasive developmental disorders. Journal of Developmental & Behavioral Pediatrics, 21, 211.CrossRefGoogle ScholarPubMed
Constantino, J. N., & Todd, R. D. (2003). Autistic traits in the general population: A twin study. Archives of General Psychiatry, 60, 524530.CrossRefGoogle ScholarPubMed
Cornblatt, B. A., Auther, A. M., Niendam, T., Smith, C. W., Zinberg, J., Bearden, C. E., et al. (2007). Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia. Schizophrenia Bulletin, 33, 688702.CrossRefGoogle ScholarPubMed
Couture, S. M., Penn, D. L., Losh, M., Adolphs, R., Hurley, R., & Piven, J. (2010). Comparison of social cognitive functioning in schizophrenia and high functioning autism: More convergence than divergence. Psychological Medicine, 40, 569579.Google Scholar
Couture, S. M., Penn, D. L., & Roberts, D. L. (2006). The functional significance of social cognition in schizophrenia: A review. Schizophrenia Bulletin, 32(Suppl. 1), S44S63.CrossRefGoogle ScholarPubMed
Dadds, M. R., Hawes, D. J., Frost, A. D., Vassallo, S., Bunn, P., Hunter, K., et al. (2009). Learning to “talk the talk”: The relationship of psychopathic traits to deficits in empathy across childhood. Journal of Child Psychology and Psychiatry, 50, 599606.CrossRefGoogle ScholarPubMed
da Silva Alves, F., Schmitz, N., Bloemen, O., van der Meer, J., Meijer, J., Boot, E., et al. (2011). White matter abnormalities in adults with 22q11 deletion syndrome with and without schizophrenia. Schizophrenia Research, 132, 7583.Google Scholar
Davidson, M., Reichenberg, A., Rabinowitz, J., Weiser, M., Kaplan, Z., & Mark, M. (1999). Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. American Journal of Psychiatry, 156, 13281335.Google Scholar
Di Martino, A., Ross, K., Uddin, L. Q., Sklar, A. B., Castellanos, F. X., & Milham, M. P. (2009). Functional brain correlates of social and nonsocial processes in autism spectrum disorders: An activation likelihood estimation meta-analysis. Biological Psychiatry, 65, 6374.Google Scholar
Di Martino, A., Shehzad, Z., Kelly, C., Roy, A. K., Gee, D. G., Uddin, L. Q., et al. (2009). Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults. American Journal of Psychiatry, 166, 891899.Google Scholar
Done, D. J., Crow, T. J., Johnstone, E. C., & Sacker, A. (1994). Childhood antecedents of schizophrenia and affective illness: Social adjustment at ages 7 and 11. British Medical Journal, 309, 699703.Google Scholar
Durkin, K., & Conti-Ramsden, G. (2007). Language, social behavior, and the quality of friendships in adolescents with and without a history of specific language impairment. Child Development, 78, 14411457.CrossRefGoogle ScholarPubMed
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1997). Structured Clinical Interview for DSM-IV Axis I disorders: Patient edition. New York: New York State Psychiatric Institute, Biometrics Research.Google Scholar
Geschwind, D. H., & Levitt, P. (2007). Autism spectrum disorders: Developmental disconnection syndromes. Current Opinion in Neurobiology, 17, 103111.CrossRefGoogle ScholarPubMed
Gorna, K., & Rybakowski, J. (1995). Social functioning of patients with schizophrenia: A follow-up study. Psychiatria Polska, 29, 619629.Google Scholar
Hambrecht, M., Lammertink, M., Klosterkotter, J., Matuschek, E., & Pukrop, R. (2002). Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinic. British Journal of Psychiatry, 43, s30s37.Google Scholar
Jahshan, C., Heaton, R. K., Golshan, S., & Cadenhead, K. S. (2010). Course of neurocognitive deficits in the prodrome and first episode of schizophrenia. Neuropsychology, 24, 109120.CrossRefGoogle ScholarPubMed
Jones, B. R., Thapar, A., Lewis, G., & Zammit, S. (2012). The association between early autistic traits and psychotic experiences in adolescence. Schizophrenia Research, 135, 164169.Google Scholar
Karlsgodt, K. H., Sun, D., Jimenez, A. M., Lutkenhoff, E. S., Willhite, R., van Erp, T. G., et al. (2008). Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia. Development and Psychopathology, 20, 12971327.Google Scholar
Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., et al. (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 980988.CrossRefGoogle ScholarPubMed
Kurtz, M. M., & Mueser, K. T. (2008). A meta-analysis of controlled research on social skills training for schizophrenia. Journal of Consulting and Clinical Psychology, 76, 491504.Google Scholar
Laugeson, E. A., Frankel, F., Mogil, C., & Dillon, A. R. (2009). Parent-assisted social skills training to improve friendships in teens with autism spectrum disorders. Journal of Autism and Developmental Disorders, 39, 596606.Google Scholar
McGlashan, T. H. (2001). Structured Interview for Prodromal Syndromes (SIPS). New Haven, CT: Yale University.Google Scholar
McGorry, P. D., Hickie, I. B., Yung, A. R., Pantelis, C., & Jackson, H. J. (2006). Clinical staging of psychiatric disorders: A heuristic framework for choosing earlier, safer and more effective interventions. Australian and New Zealand Journal of Psychiatry, 40, 616622.Google Scholar
Meyer, S. E., Bearden, C. E., Lux, S. R., Gordon, J. L., Johnson, J. K., O'Brien, M. P., et al. (2005). The psychosis prodrome in adolescent patients viewed through the lens of DSM-IV. Journal of Child and Adolescent Psychopharmacology, 15, 434451.CrossRefGoogle ScholarPubMed
Monahan, K. C., & Steinberg, L. (2011). Accentuation of individual differences in social competence during the transition to adolescence. Journal of Research on Adolescence, 21, 576585.CrossRefGoogle ScholarPubMed
Murray, M. J., Mayes, S. D., & Smith, L. A. (2011). Brief report: Excellent agreement between two brief autism scales (Checklist for Autism Spectrum Disorder and Social Responsiveness Scale) completed independently by parents and the Autism Diagnostic Interview—Revised. Journal of Autism and Developmental Disorders, 41, 15861590.Google Scholar
Niendam, T. A., Bearden, C. E., Johnson, J. K., McKinley, M., Loewy, R., O'Brien, M., et al. (2006). Neurocognitive performance and functional disability in the psychosis prodrome. Schizophrenia Research, 84, 100111.Google Scholar
Paus, T., Keshavan, M., & Giedd, J. N. (2008). Why do many psychiatric disorders emerge during adolescence? Nature Reviews Neuroscience, 9, 947957.Google Scholar
Rabinowitz, J., Levine, S. Z., Garibaldi, G., Bugarski-Kirola, D., Berardo, C. G., & Kapur, S. (2012). Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: Analysis of CATIE data. Schizophrenia Research, 137, 147150.Google Scholar
Rapoport, J., Chavez, A., Greenstein, D., Addington, A., & Gogtay, N. (2009). Autism spectrum disorders and childhood-onset schizophrenia: Clinical and biological contributions to a relation revisited. Journal of the American Academy of Child & Adolescent Psychiatry, 48, 1018.CrossRefGoogle ScholarPubMed
Reiersen, A. M., Constantino, J. N., Volk, H. E., & Todd, R. D. (2007). Autistic traits in a population-based ADHD twin sample. Journal of Child Psychology and Psychiatry, 48, 464472.Google Scholar
Roisman, G. I., Masten, A. S., Coatsworth, J. D., & Tellegen, A. (2004). Salient and emerging developmental tasks in the transition to adulthood. Child Development, 75, 123133.Google Scholar
Schlosser, D. A., Jacobson, S., Chen, Q., Sugar, C. A., Niendam, T. A., Li, G., et al. (2012). Recovery from an at-risk state: Clinical and functional outcomes of putatively prodromal youth who do not develop psychosis. Schizophrenia Bulletin, 38, 12251233.Google Scholar
Sporn, A. L., Addington, A. M., Gogtay, N., Ordonez, A. E., Gornick, M., Clasen, L., et al. (2004). Pervasive developmental disorder and childhood-onset schizophrenia: Comorbid disorder or a phenotypic variant of a very early onset illness? Biological Psychiatry, 55, 989994.Google Scholar
Strauss, G. P., Allen, D. N., Miski, P., Buchanan, R. W., Kirkpatrick, B., & Carpenter, W. T. Jr., (2012). Differential patterns of premorbid social and academic deterioration in deficit and nondeficit schizophrenia. Schizophrenia Research, 135, 134138.Google Scholar
Trentacosta, C. J., & Fine, S. E. (2010). Emotion knowledge, social competence, and behavior problems in childhood and adolescence: A meta-analytic review. Social Development, 19, 129.Google Scholar
Wechsler, D. (1999). Manual for the Wechsler Abbreviated Intelligence Scale (WASI). San Antonio, TX: Psychological Corporation.Google Scholar