Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-26T06:54:06.087Z Has data issue: false hasContentIssue false
  • English
  • Français

Complement Fixation in Pulmonary Tuberculosis

Published online by Cambridge University Press:  15 May 2009

J. A. D. Radcliffe
J. A. D. Radcliffe
Affiliation:
Pathologist, King Edward VII Sanatorium, Midhurst.
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. A fresh emulsion of tubercle bacilli in salt solution when used as the antigen will give about 90 % of positive results in cases of pulmonary tuberculosis, whilst in healthy persons the result is negative.

2. In cases suspected of pulmonary tuberculosis, the results of this test conform closely to those given by a combination of the opsonic index test with injections of tuberculin, and so may be of value in diagnosis.

3. Diseases other than tuberculosis have always been negative, but only a small number of such cases have been examined.

4. An emulsion of tubercle bacilli when used as an antigen must be freshly prepared immediately before use, and should be made from a young subculture.

5. Owing to the differences in complements, they should always be titrated in the presence of the antigen, and probably also in the presence of both antigen and normal serum.

6. Exercise does not seem to affect the result of the reaction in any way, but a course of tuberculin treatment leads to an increase in the complement-fixing bodies of the serum in some cases.

Type
Research Article
Information
Journal of Hygiene , Volume 15 , Issue 1 , July 1915 , pp. 36 - 50
Copyright
Copyright © Cambridge University Press 1915

References

REFERENCES

1.Bordet, et Gengou, (1903). Compt. rend. de l' Académie des Sciences, cxxxvii. 351.Google Scholar
2.Wassermann, und Bruck, (1906). Deutsche med. Wochenschr. xxxii. 449.Google Scholar
3.Citron, (1907). Berlin. klin. Wochensch. iii. 1135.Google Scholar
4.Morgenroth, und Rabinowitsch, (1907). Deutsche med. Wochenschr. xxxiii. 750.Google Scholar
5.Hammer, (1912). Münch. med. Wochenschr. lix. 1750.Google Scholar
6.Bang, und Andersen, (1913). Centralblatt f. Bakt. Originale lxix. 517.Google Scholar
7.Besredka, et Manoukhine, (1914). Compt. rend. de la Soc. de Biolog. lxxvi. 180.Google Scholar
8.Calmette, et Massol, (1914). Annales de l' Institut Pasteur, xxviii. 338.Google Scholar
9.Renaux, (1914). Compt. rendu de la Soc. de Biolog. lxxvi. 864.Google Scholar
10.Fildes, and McIntosh, (1913). Brain, xxxvi. p. 193.Google Scholar