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Epidermal tissue as a primary site of replication of lymphocytic choriomeningitis virus in small experimental hosts

Published online by Cambridge University Press:  15 May 2009

H. H. Skinner  and
E. H. Knight
H. H. Skinner
Affiliation:
The Animal Virus Research Institute, Pirbright, Surrey
E. H. Knight
Affiliation:
The Animal Virus Research Institute, Pirbright, Surrey
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Summary

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When fresh urine from LCM tolerantly infected mice was applied to small areas of excoriated skin of guinea-pigs undiluted or diluted 10−1, a high LCM infectivity developed in the local dermal tissue within 3 days and quickly spread to the lymphatic system. The skin at this site of infection became erythematous 10–12 days after infection and a few days later a rash was often seen in the hairless skin around the mammary teats. A viraemia was first detected at about 8 days after infection and persisted for at least 8 days, during which time a high infectivity titre in skin not only at the infection site but also distal to it suggested that there was a generalized active infection of the dermis. Infectivity in the tongue was simultaneously high and probably associated with erosions of the tongue tip seen a day or two later than the teat rash.

In similar experiments in hamsters and rabbits, indications were again that lightly injured dermis was a primary site of virus replication. These observations should lead to the dermal route receiving greater attention as a potential route of infection of man when exposed to infectious excretions of reservoir hosts of arena-viruses.

Type
Research Article
Information
Journal of Hygiene , Volume 82 , Issue 1 , February 1979 , pp. 21 - 30
Copyright
Copyright © Cambridge University Press 1979

References

REFERENCE

Biggar, R. J., Woodall, J. P., Walter, P. D. & Haughie, G. E. (1975). Lymphocytic choriomeningitis outbreak associated with pet hamsters. Fifty-seven cases from New York State. Journal of the American Medical Association 232, 494.CrossRefGoogle ScholarPubMed
Blanc, G., Bruneau, J., Delage, B. & Poitrot, R. (1951). Étude comparative de virus de chorioméningite lymphocytaire d'origine humaine (W. E. Armstrong) et animale (pneumopathie du cobaye). Bulletin de l'Académie nationale de Médecine 135, 520.Google Scholar
Findlay, G. M., Alcock, N. S. & Stern, R. O. (1936). The virus aetiology of one form of lymphocytic meningitis. Lancet i, 650.CrossRefGoogle Scholar
Hoyland, F., Knight, E. H. & Skinner, H. H. (1972). Eradication of lymphocytic choriomeningitis (LCM) virus – a human pathogen – from a mouse breeding colony. Journal of the Institute of Animal Technicians 23, 6.Google Scholar
Lehmann-Grube, F. (1971). Lymphocytic choriomeningitis virus. Virology Monographs, vol. 10. Berlin: Springer-Verlag.Google Scholar
Mimms, C. A. (1966). Pathogenesis of rashes in virus diseases. Bacteriological Reviews 30, 739.CrossRefGoogle Scholar
Platt, H. (1963). The susceptibility of the skin and epidermoid mucous membranes to virus infection in man and other animals. Guy's Hospital Reports 112, 479.Google ScholarPubMed
Roger, F. (1962). Études sur le pouvoir pathogène du virus de la chorioméningite lymphocytaire. I. Réactivité dermique chez le lapin. Annales de l'Institut Pasteur 103, 639.Google Scholar
Roger, F. (1963). Études sur le pouvoir pathogène expérimental du virus de la chorioméningite lymphocytaire. II. Inoculation dans le derme du cobaye. Annales de l'Institut Pasteur 104, 274.Google Scholar
Shaughnessy, H. J. & A. (1939). Experimental infection of Dermacentor andersoni, Stiles, with the virus of lymphocytic choriomeningitis. American Journal of Public Health 29, 1103.CrossRefGoogle ScholarPubMed
Shaughnessy, H. J. & Zichis, J. (1940). Infection of guinea-pigs by application of virus of lymphocytic choriomengitis to their normal skins. Journal of Experimental Medicine 72, 331.CrossRefGoogle Scholar
Skinner, H. H. (1957). The virus of vesicular stomatitis in small experimental hosts. II. Guinea-pigs and rabbits. Journal of Comparative Pathology and Therapeutics 67, 87.Google Scholar
Skinner, H. H. & Knight, E. H. (1973). Natural routes for post-natal transmission of murine lymphocytic choriomeningitis. Laboratory Animals 7, 171.CrossRefGoogle ScholarPubMed
Skinner, H. H. & Knight, E. H. (1976). The hamster as a secondary reservoir host of lymphocytic choriomeningitis virus. Journal of Hygiene 76, 299.Google Scholar
Skinner, H. H., Knight, E. H. & Grove, R. (1977). Murine lymphocytic choriemeningitis: the history of a natural cross-infection from wild to laboratory mice. Laboratory Animals 11, 29.Google Scholar
Smadel, J. E., Green, R. H., Paltauf, R. M. & Gonzales, T. A. (1942). Lymphocytic choriomeningitis: two human fatalities following an unusual febrile illness. Proceedings of the Society for Experimental Biology and Medicine 49, 683.CrossRefGoogle Scholar