Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-27T11:48:34.195Z Has data issue: false hasContentIssue false
  • English
  • Français

Homologous and heterologous antibody responses to subunit influenza virus vaccine

Published online by Cambridge University Press:  15 May 2009

Brian J. Feery ,
M. G. Evered  and
Kathleen Hayes
Brian J. Feery
Affiliation:
WHO National Influenza Centre, Commonwealth Serum Laboratories, Parkville 3052, Australia
M. G. Evered
Affiliation:
WHO National Influenza Centre, Commonwealth Serum Laboratories, Parkville 3052, Australia
Kathleen Hayes
Affiliation:
Department of Pediatrics, Monash University, Melbourne 3000, Australia
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In a group of 32 adult volunteers given subunit influenza virus vaccine containing 250 international units (i.u.) of A/Victoria/3/75, 250 i.u. of A/Scotland/ 840/74 and 300 i.u. of B/Hong Kong/8/73, there were substantial increases in the geometric mean homologous haemagglutination-inhibiting (HI) antibody titres. There was also substantial boosting of the antibodies to the earlier variants of the Hong Kong (H3N2) series and to a later variant of the Asian (H2N2) series. There was no boosting of antibodies to the A/FM/1/47 strain, a representative member of the H1N1 series, but two individuals showed substantial rises to A/PR/8/34 (H0N1).

There were increases in the HI titre of antibodies cross reactive with two recent isolations, A/Texas/1/77, and A/Victoria/35/77, but the majority of vaccinees failed to reach antibody titres likely to be protective against such strains.

Type
Research Article
Information
Journal of Hygiene , Volume 81 , Issue 3 , December 1978 , pp. 331 - 336
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Dowdle, W. R., Coleman, M. T., Hall, E. C. & Knez, V. (1969). Properties of the Hong Kong influenza virus. Antigenic relationship of the Hong Kong virus haemagglutinin to that of other human influenza viruses. Bulletin of the World Health Organization 41, 419–24.Google Scholar
Dowdle, W. R., Marine, W. M., Coleman, M. & Knez, V. (1972). Haemagglutinin relationships of Hong Kong (113) and Asian (H2) influenza strains delineated by antigen-specific recombinants. Journal of General Virology 16, 127–34.CrossRefGoogle Scholar
Feery, B. J., Cheyne, I. M., Hampson, A. W. & Atkinson, M. I. E. (1976). Antibody response to one and two doses of influenza virus subunit vaccine. Medical Journal of Australia 1, 186–9.CrossRefGoogle ScholarPubMed
Feery, B. J., Hampson, A. W., Forsyth, J. R. L. & Evered, M. G. (1977). Effect of dose on antibody response to subunit influenza vaccine. Medical Journal of Australia 2, 324–7.CrossRefGoogle ScholarPubMed
Francis, T. Jnr, Davenport, F. M. & Hennessy, A. V. (1953). Epidemiological recapitulation of human infection with different strains of influenza virus. Transactions of the Association of American Physicians 66, 231–8.Google Scholar
Francis, T. (1960). On the doctrine of original antigenic sin. Proceedings of the American Philosophical Society 104, 572–8.Google Scholar
Gill, P. W., Babbage, N. F., Gunton, P. E., Flower, W. & Garrett, D. A. (1971). Efficacy of influenza virus subunit vaccine in 1970. Medical Journal of Australia 2, 1005–8.CrossRefGoogle Scholar
Gill, P. (1973). Influenza in general practice. Medical Journal of Australia Supplement 1, 24–8.CrossRefGoogle ScholarPubMed
Hobson, D., Curry, R. L., Beare, A. S. & Ward-Gardner, A. (1972). The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses. Journal of Hygiene 70, 767–77.Google ScholarPubMed
Hoskins, T. W., Davies, J. R., Allchen, A., Miller, C. L. & Pollock, T. M. (1973). Controlled trial of inactivated influenza A vaccine containing the A/Hong Kong strain during an outbreak of influenza due to the A/England/42/72 strain. Lancet ii, 116–20.CrossRefGoogle Scholar
Marine, W. M., Workman, W. M. & Webster, R. G. (1969). Immunological interrelationships of Hong Kong, Asian and Equi 2 influenza viruses in man. Bulletin of the World Health Organization 41, 475–82.Google ScholarPubMed
Morita, M., Suto, T. & Ishida, N. (1972). Antigenic memory in man in response to sequential infections with influenza A virus. Journal of Infectious Diseases 126, 61–8.CrossRefGoogle Scholar
Noble, G. R., Kaye, H. S., Kendal, A. P. & Dowdle, W. R. (1977). Age-related heterologous antibody responses to influenza virus vaccination. Journal of Infectious Diseases 136, Supplement, 686–92.CrossRefGoogle ScholarPubMed
Palmer, D. F., Coleman, M. T., Dowdle, W. R. & Schild, G. C. (1975). Advanced laboratory techniques for influenza diagnosis. Immunology Series No. 6, US Department of Health, Education and Welfare, 26–45.Google Scholar
Ruben, F. L., Johnston, F. & Streiff, E. J. (1974). Influenza in a partially immunized aged population. Journal of the American Medical Association 230, 863–6.CrossRefGoogle Scholar
Virelizier, J. L., Postlethwaite, R., Schild, G. C. & Allison, A. C. (1974). Antibody responses to antigenic determinants of influenza virus haemagglutinin. II. Journal of Experimental Medicine 140, 1571–8.CrossRefGoogle Scholar
Webster, R. G. (1966). Original antigenic sin in ferrets. The response to sequential infections with influenza viruses. Journal of Immunology 97, 177–83.CrossRefGoogle Scholar