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The incidence of infection with poliovirus and other viruses in cases of aseptic meningitis (‘nonparalytic poliomyelitis’) in Sheffield in 1954

Published online by Cambridge University Press:  15 May 2009

D. A. J. Tyrrell ,
D. Balducci ,
B. Snell  and
T. Elisabeth Zaiman
D. A. J. Tyrrell
Affiliation:
From theVirus Research Laboratory of the University of Sheffield, Lodge Moor Hospital, Sheffield, 10
D. Balducci
Affiliation:
From theVirus Research Laboratory of the University of Sheffield, Lodge Moor Hospital, Sheffield, 10
B. Snell
Affiliation:
From theVirus Research Laboratory of the University of Sheffield, Lodge Moor Hospital, Sheffield, 10
T. Elisabeth Zaiman
Affiliation:
From theVirus Research Laboratory of the University of Sheffield, Lodge Moor Hospital, Sheffield, 10
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1. Sixteen cases of paralytic poliomyelitis and twenty-four cases of aseptic meningitis (‘non-paralytic poliomyelitis’) occurring in the Sheffield area were studied clinically and by virological methods.

2. Poliovirus was isolated from thirteen of the sixteen cases of paralytic poliomyelitis and from three of the twenty-four cases of aseptic meningitis. In another two of the cases of paralytic poliomyelitis and another six of the cases of aseptic meningitis serological evidence of poliovirus infection was obtained.

3. Serological evidence of Coxsackie virus infection was found in four of the cases of aseptic meningitis; but in one there was also clear-cut evidence of poliovirus Type 3 infection, and in another it seemed that the infection was contracted in hospital. Evidence of Coxsackie virus infection was also obtained in five cases of paralytic poliomyelitis.

4. Serological evidence of Adenovirus infection was found in one case of aseptic meningitis.

5. No acceptable evidence was found of infection with Columbia SK or related viruses, or with the virus of lymphocytic choriomeningitis.

6. From one patient with aseptic meningitis an unidentified virus was isolated.

We wish to thank Dr J. Kennedy for permission to study patients and Prof. C. P. Beattie and Prof. C. H. Stuart-Harris for help in preparing the manuscript.

Type
Research Article
Information
Journal of Hygiene , Volume 55 , Issue 4 , December 1957 , pp. 457 - 463
Copyright
Copyright © Cambridge University Press 1957

References

REFERENCES

Adair, C. V., Gauld, R. L. & Smadel, J. E. (1953). Aseptic meningitis, a disease of diverse etiology: clinical and etiologic studies on 854 cases. Ann. intern. Med. 39, 675.Google Scholar
Balducci, D., Tyrrell, D. A. J. & Stuart-Harris, C. H. (1956). Complement fixing antigens of herpes simplex virus. Arch. ges. Virusforsch. 7, 28.Google Scholar
Balducci, D., Zaiman, T. E. & Tyrrell, D. A. J. (1956). Laboratory studies of APC and influenza C viruses. Brit. J. exp. Path. 37, 205.Google ScholarPubMed
Beale, A. J., Duncan, D., Stackiw, W., Davis, N., Dempster, G. & Rhodes, A. J. (1956). Further observations on the laboratory diagnosis of aseptic meningitis caused by Group B Coxsackie viruses. Canad. J. publ. Hlth. 47, 179.Google Scholar
Bieling, R. & Koch, F. (1956). Über die Bedeutung des Columbia SK-Virus in der Humanen Pathologie. Dsch. med. Wschr. 81, 294.Google Scholar
Committee on ECHO Viruses (1955). Enteric cytopathogenic human orphan (ECHO) viruses. Science, 122, 1187.CrossRefGoogle Scholar
Davis, D. C. & Melnick, J. L. (1956). Association of ECHO virus Type 6 with aseptic meningitis. Proc. Soc. exp. Biol., N.Y., 92, 839.CrossRefGoogle ScholarPubMed
Francis, T. Jr., Korns, R. F., Woight, R. B., Boisen, M., Hemphill, F. N., Napier, J. A. & Tolchinsky, E. (1955). An evaluation of the 1954 poliomyelitis vaccine trials. Amer. J. Publ. Hlth, 45, May Supplement.Google ScholarPubMed
Galpin, J. F. & Macrae, A. D. (1953). An outbreak of benign meningo-encephalitis Isolation of Coxsackie virus. Lancet, 1, 372.Google Scholar
Godenne, M. O. & Riordan, J. T. (1955). Tissue culture diagnosis of poliomyelitis and aseptic meningitis. J. Amer. med. Assoc. 158, 707.CrossRefGoogle ScholarPubMed
Horvath, B. & Jungeblut, C. W. (1952). Studies on haemagglutination by Columbia SK virus. J. Immunol. 68, 627.Google Scholar
Johnsson, T. (1955). The occurrence of Coxsackie virus in a hospital material of paralytic poliomyelitis, aseptic meningitis and a miscellaneous group of diseases. Arch. ges. Virusforsch. 2, 250.CrossRefGoogle Scholar
Karzon, D. T., Baron, A. L., Winkelstein, W. Jr & Cohen, S. (1956). Isolation of ECHO virus type 6 during outbreak of seasonal aseptic meningitis. J. Amer. med. Assoc. 162, 1298.Google Scholar
Kirby, W. M. M. & Evans, C. A. (1955). Tissue culture isolation of Coxsackie group B viruses in aseptic meningitis. J. Amer. med. Assoc. 159, 743.Google Scholar
Krech, U. (1957). Über das Vorkommen von ‘ECHO-virus’ in der Schweiz Schweiz. med. Wschr. 87, 558.Google Scholar
McLeod, D. L., Beale, A. J., McNaughton, G. A. & Rhodes, A. J. (1956). Clinical features of aseptic meningitis caused by Coxsackie B virus. Lancet, 2, 70.Google Scholar
Melnick, J. L. (1955). Tissue culture techniques and their application to original isolation, growth, and assay of poliomyelitis and orphan viruses. Ann. N.Y. Acad. Sci. 61, 754.CrossRefGoogle ScholarPubMed
Melnick, J. L. & Ledinko, N. (1950). Immunological reactions of the Coxsackie viruses. I. Neutralization tests: technic and application. J. exp. Med. 92, 463.Google Scholar
Melnick, J. L., Shaw, E. W. & Curnen, E. C. (1949). A virus isolated from patients diagnosed as non-paralytic poliomyelitis or aseptic meningitis. Proc. Soc. exp. Biol., N.Y., 71, 344.Google Scholar
Nolan, J. P., Wilmer, B. H. & Melnick, J. L. (1955). Poliomyelitis. Its highly invasive nature and narrow stream of infection in a community of high socio-economic level. New Eng. J. Med. 253, 945.Google Scholar
Paul, J. R. & Melnick, J. L. (1956). Poliomyelitis. Diagnostic procedures for virus and rickettsial diseases. Ed. T., FrancisJrAmerican Public Health Association, New York.Google Scholar
Report, Virus Reference Laboratory, Colindale, London (1953). Suspected virus infections of respiratory tract and central nervous system. Diagnosis by serological methods. Lancet, i, 85.Google Scholar
Tyrrell, D. A. J., Keeble, S. A. & Wood, S. W. (1956). Antigenicity studies on Salk-type poliomyelitis vaccine. Brit. med. J. 1, 598.Google Scholar
Tyrrell, D. A. J., Lane, R. R. & Snell, B. (1957). Further studies of an epidemic of exanthem associated with aseptic meningitis. Quart. J. Med. in press.Google Scholar
Wilkins, A. J. W., Kotze, D. M., Melvin, J., Gear, J., Prinsloo, F. R. & Kirsch, Z. (1955). Meningo-encephalitis due to Coxsackie B virus in Southern Rhodesia. S. Afr. med. J. 29, 25.Google ScholarPubMed