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The Relation of the Tubercle Bacillus to Lymphadenoma

Published online by Cambridge University Press:  15 May 2009

C. C. Twort
C. C. Twort
Affiliation:
From the Pathological Department, St Bartholomew's Hospital.
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IN 1913, Fraenkel and Much1 inoculated monkeys, guinea-pigs, rabbits and dogs intraperitoneally with large quantities of material obtained from two cases of Lymphadenoma, no accompanying tubercular disease being demonstrable. The material was broken down with antiformin, and as a result of the injections, the guinea-pigs died within three months. The authors state that besides finding extensive tubercular disease, there were hard, white nodules, the size of a cherry stone, on the serous coverings of the stomach and mesentery. Also, in addition to genuine tubercular disease of the lymphatic glands, they found giant cells, not of Langhans' type, as well as a stroma rich in fibriles, similar to what is found in Lymphadenoma. The nodules on the serous surfaces showed a picture corresponding to the terminal fibrous stage of a lymphadenomatous focus, with a scarcity of cellular elements.

Type
Research Article
Information
Journal of Hygiene , Volume 23 , Issue 3 , December 1924 , pp. 260 - 267
Copyright
Copyright © Cambridge University Press 1924

References

1 Fraenkel, E. and Much, H. (1923), Zeitschr. f. Hygiene u. Infektionskr. XCIX. 391.CrossRefGoogle Scholar