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Sibling familial risk ratio of meningococcal disease in UK Caucasians

Published online by Cambridge University Press:  25 June 2003

E. HARALAMBOUS ,
H. A. WEISS ,
A. RADALOWICZ ,
M. L. HIBBERD ,
R. BOOY  and
M. LEVIN
E. HARALAMBOUS
Affiliation:
Department of Paediatrics, Imperial College Faculty of Medicine, St. Mary's Hospital, Norfolk Place, Paddington, London W2 1PG, UK
H. A. WEISS
Affiliation:
MRC Tropical Epidemiology Group, Infectious Diseases Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
A. RADALOWICZ
Affiliation:
MRC Tropical Epidemiology Group, Infectious Diseases Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
M. L. HIBBERD
Affiliation:
Department of Paediatrics, Imperial College Faculty of Medicine, St. Mary's Hospital, Norfolk Place, Paddington, London W2 1PG, UK
R. BOOY
Affiliation:
Department of Child Health, Queen Mary's School of Medicine and Dentistry, Barts and the London, Whitechapel, Stepney Way, London E1 1BB, UK
M. LEVIN
Affiliation:
Department of Paediatrics, Imperial College Faculty of Medicine, St. Mary's Hospital, Norfolk Place, Paddington, London W2 1PG, UK
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Abstract

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To quantify the host genetic component of meningococcal disease (MD) susceptibility, the sibling risk ratio (λs) was calculated as the ratio of observed MD cases among 845 siblings of 443 UK Caucasian cases to that expected, calculated from age-calendar year specific rates for England and Wales. Twenty-seven siblings contracted MD compared with an expected 0·89, generating a λs value of 30·3. Overestimation of λs due to Neisseria meningitidis exposure was minimized by excluding siblings with MD onset within set time points of the index case. Irrespective of whether siblings contracted MD more than 1, 3, 6, 9 or 12 months after the index case, the λs varied slightly (λs range: 8·2–11·9), suggesting that host genetic factors may contribute approximately one third of the total λs. Social class distribution did not differ between MD cases and the general population of England and Wales. This study is the first to calculate λs for MD and establishes that susceptibility to MD has a significant host genetic component.

Type
Research Article
Information
Epidemiology & Infection , Volume 130 , Issue 3 , June 2003 , pp. 413 - 418
Copyright
© 2003 Cambridge University Press