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Acidified propofol retains its anaesthetic potency after storage

Published online by Cambridge University Press:  16 August 2006

M. Eriksson ,
S. Englesson  and
P. Hartvig
M. Eriksson
Affiliation:
Department of Anaesthesia and Intensive Care, University Hospital, S-751 85, Uppsala, Sweden
S. Englesson
Affiliation:
Department of Anaesthesia and Intensive Care, University Hospital, S-751 85, Uppsala, Sweden
P. Hartvig
Affiliation:
Hospital Pharmacy, University Hospital, S-751 85, Uppsala, Sweden
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Abstract

The reduction in propofol-induced pain on injection caused by the addition of lignocaine results mainly from a drop in pH, which reduces the concentration of propofol in the aqueous phase of the emulsion. It is not an effect of the local anaesthetic per se. Propofol emulsion mixed with lignocaine destabilizes within hours. We mixed 10 parts of propofol 1% emulsion with one part of 0.0064 m HCl or 0.013 m HCl, respectively. These mixtures were stored for 3 months and compared with a freshly prepared solution of propofol 1% emulsion and saline, in the same proportion, regarding their ability to induce anaesthesia in the rat. There was no significant difference in the amount of propofol required to induce anaesthesia, nor was there any difference in recovery time between the three groups.

Keywords

anaestheticsintravenouspropofollig-nocaineanimalsratpaininjectionemulsionpH
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 16 , Issue 3 , March 1999 , pp. 166 - 168
Copyright
1999 European Society of Anaesthesiology

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