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Anti-emetic efficacy of prophylactic granisetron compared with perphenazine for the prevention of post-operative vomiting in children

Published online by Cambridge University Press:  16 August 2006

Y. Fujii ,
Y. Saitoh ,
H. Tanaka  and
H. Toyooka
Y. Fujii
Affiliation:
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan
Y. Saitoh
Affiliation:
Department of Anaesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan
H. Tanaka
Affiliation:
Department of Anaesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan
H. Toyooka
Affiliation:
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan
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Abstract

We have compared the efficacy of granisetron with perphenazine in the prevention of vomiting after tonsillectomy with or without adenoidectomy in children. In a prospective, randomized, double-blind study, 90 paediatric patients, ASA I, aged 4–10 years, received granisetron 40 mg kg−1 or perphenazine 70 mg kg−1 (n=45 each) intravenously immediately after an inhalation induction of anaesthesia. A standard general anaesthetic technique was employed throughout. A complete response, defined as no emesis with no need for another rescue antiemetic, during the first 3 h (0–3 h) after anaesthesia was 87% with granisetron and 78% with perphenazine (P=0.204). The corresponding incidence during the next 21 h (3–24 h) after anaesthesia was 87% and 62% (P=0.007). No clinically serious adverse events were observed in any of the groups. We conclude that granisetron is a better anti-emetic than perphenazine for the long-term prevention of post-operative vomiting in children undergoing general anaesthesia for tonsillectomy.

Keywords

complicationsvomitingantiemeticsgranisetronperphenazinesurgerypaediatrictonsillectomy
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 16 , Issue 5 , May 1999 , pp. 304 - 307
Copyright
1999 European Society of Anaesthesiology

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