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Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis

Published online by Cambridge University Press:  23 December 2004

G. Marx ,
T. Cope ,
L. McCrossan ,
S. Swaraj ,
C. Cowan ,
S. M. Mostafa ,
R. Wenstone  and
M. Leuwer
G. Marx
Affiliation:
University of Liverpool, University Department of Anaesthesia, Liverpool, UK
T. Cope
Affiliation:
Aintree University Hospital, Department of Anaesthesia, Liverpool, UK
L. McCrossan
Affiliation:
Royal Liverpool University Hospital, Department of Anaesthesia and Intensive Care, Liverpool, UK
S. Swaraj
Affiliation:
Royal Liverpool University Hospital, Department of Anaesthesia and Intensive Care, Liverpool, UK
C. Cowan
Affiliation:
Royal Liverpool University Hospital, Department of Anaesthesia and Intensive Care, Liverpool, UK
S. M. Mostafa
Affiliation:
Royal Liverpool University Hospital, Department of Anaesthesia and Intensive Care, Liverpool, UK
R. Wenstone
Affiliation:
Royal Liverpool University Hospital, Department of Anaesthesia and Intensive Care, Liverpool, UK
M. Leuwer
Affiliation:
University of Liverpool, University Department of Anaesthesia, Liverpool, UK
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Abstract

Summary

Background and objective: Our hypothesis was that stroke volume variation during mechanical ventilation of the lungs would allow accurate prediction and monitoring of changes in cardiac index in response to fluid loading in patients with severe sepsis.

Methods: This was a prospective clinical study in a university hospital. Ten mechanically ventilated patients with severe sepsis or septic shock were given fluid loading with 500 mL 10% hydroxyethylstarch 200/0.5 over 30 min. Before and after fluid loading pulmonary arterial occlusion pressure and central venous pressure were measured. Intrathoracic blood volume index, stroke volume variation and cardiac index were measured by the transpulmonary thermodilution technique. After verifying normal distribution of the data (skewness <1.0) the paired t-test was used for statistical analysis.

Results: After fluid loading stroke volume variation decreased significantly, whereas central venous pressure, pulmonary arterial occlusion pressure, intrathoracic blood volume index and cardiac index increased significantly. Changes of cardiac index in response to fluid loading were correlated to baseline values of stroke volume variation (r = 0.64, P = 0.02) and intrathoracic blood volume index (r = −0.73, P = 0.009). Changes in cardiac index were significantly correlated to percentage changes in stroke volume variation (r = −0.65, P < 0.001) and changes in intrathoracic blood volume index (r = 0.52, P = 0.002), whereas changes in cardiac index revealed no significant correlation to changes in central venous pressure (r = 0.28, P = 0.07) and changes in pulmonary arterial occlusion pressure (r = 0.29, P = 0.06).

Conclusions: Measuring stroke volume variation may be a useful way of guiding fluid therapy in ventilated patients with severe sepsis because it allows estimation of preload and prediction of cardiac index changes in response to fluid loading.

Keywords

HAEMODYNAMICS, cardiac output, stroke volumeINFECTION, sepsis, shock, septicMULTIPLE ORGAN FAILURE, shock, septic
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 21 , Issue 2 , February 2004 , pp. 132 - 138
Copyright
2004 European Society of Anaesthesiology

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