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Do intracellular, extracellular or urinary magnesium concentrations predict renal retention of magnesium in critically ill patients?

Published online by Cambridge University Press:  13 April 2005

P. Saur ,
P. D. Niedmann ,
E. Brunner  and
D. Kettler
P. Saur
Affiliation:
Georg-August-University of Goettingen, Department of Anesthesiology, Emergency- and Intensive-Care-Medicine, Goettingen, Germany
P. D. Niedmann
Affiliation:
Georg-August-University of Goettingen, Department of Clinical Chemistry, Goettingen, Germany
E. Brunner
Affiliation:
Georg-August-University of Goettingen, Department of Medical Statistics, Goettingen, Germany
D. Kettler
Affiliation:
Georg-August-University of Goettingen, Department of Anesthesiology, Emergency- and Intensive-Care-Medicine, Goettingen, Germany
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Abstract

Summary

Background and objective: Magnesium disorders are common in hospitalized patients. In patients with low or normal magnesium, the intravenous magnesium loading test has been demonstrated to be a sensitive test to assess magnesium deficiency in critically ill patients. However, it is more time consuming and more difficult than the measurement of intracellular or extracellular magnesium concentrations. This study evaluated whether erythrocyte, plasma and urinary magnesium concentrations predict renal magnesium retention measured by the magnesium loading test.

Methods: One-hundred-and-three intensive care patients (36 females, 67 males) in a tertiary care centre and 41 healthy subjects (13 females, 28 males) took part in this prospective study. Intracellular, total plasma, ionized extracellular and urinary magnesium concentrations were measured and also magnesium retention by intravenous magnesium loading test.

Results: Total plasma magnesium concentration was poorly correlated with magnesium retention (r = 0.36, r2 = 0.13) and was the only parameter that significantly predicted magnesium retention in intensive care patients (P < 0.01). However, only 10% of the magnesium retention data were linked to the total plasma magnesium concentration.

Conclusions: Total plasma magnesium concentration predicts magnesium retention in critically ill intensive care patients but not intracellular and urinary magnesium concentrations. Only a small proportion of the magnesium retention was due to the total plasma magnesium concentration.

Keywords

MAGNESIUM, hypomagnesaemia, plasma concentrationsMAGNESIUM DEFICIENCY, magnesium excretionCRITICAL CARE
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 22 , Issue 2 , February 2005 , pp. 148 - 153
Copyright
2005 European Society of Anaesthesiology

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References

Altura BM. Introduction: importance of magnesium in physiology and medicine and the need for ion selective electrodes. Scand J Lab Invest 1994; 217: S5–S9.Google Scholar
Quamme GA. Magnesium homeostasis and urinary magnesium handling. Miner Electrolyte Metab 1993; 19: 218–225.Google Scholar
Salem M, Munoz R, Chernow B. Hypomagnesemia in critical illness. Crit Care Clin 1991; 7: 225–252.Google Scholar
Chernow B, Bamberger S, Stoiko M, et al. Hypomagnesemia in patients in postoperative intensive care. Chest 1989; 95: 391–397.Google Scholar
Whang R. Clinical disorders of magnesium metabolism. Compr Ther 1997; 23: 168–173.Google Scholar
Frankel H, Haskell R, Lee SY, Miller D, Rotondo M, Schwab CW. Hypomagnesemia in trauma patients. World J Surg 1999; 23: 966–969.Google Scholar
Rubeiz GJ, Thill-Baharozian M, Hardie D, Carlson RW. Association of hypomagnesemia and mortality in acutely ill medical patients. Crit Care Med 1993; 21: 203–209.Google Scholar
Ryzen E. Magnesium homeostasis in critically ill patients. Magnesium 1989; 8: 201–212.Google Scholar
Gullestad L, Dolva LO, Waage A, et al. Magnesium deficiency diagnosed by an intravenous loading test. Scand J Clin Lab Invest 1992; 52: 245–253.Google Scholar
Ryzen E, Elkayam U, Rude RK. Low blood mononuclear cell magnesium in intensive cardiac care unit patients. Am Heart J 1986; 111: 475–480.Google Scholar
Saur PMM, Zielmann S, Roth ATP, et al. Evaluation of magnesium deficiency in patients of an intensive care unit. Anaesth Intensivmed Notfallmed Schmerzther 1996; 1: 37–41.Google Scholar
Ryzen E, Elbaum N, Singer FR, Rude RK. Parenteral magnesium tolerance testing in the evaluation of magnesium deficiency. Magnesium 1985; 4: 137–147.Google Scholar
Khalil SI. Magnesium the forgotton cation. Int J Cardiol 1999; 68: 133–135.Google Scholar
Rude RK, Singer FR. Magnesium deficiency and excess. Ann Rev Med 1981; 32: 245–259.Google Scholar
Quamme GA. Laboratory evaluation of magnesium status. Urinary function and free intracellular magnesium concentration. Clin Lab Med 1993; 13: 209–213.Google Scholar
Sanders GT, Huijgen HJ, Sanders R. Magnesium in disease: a review with special emphasis on the serum ionized magnesium. Clin Chem Lab Med 1999; 37: 1011–1033.Google Scholar
Elin RJ. Magnesium metabolism in health and disease. Dis Mon 1988; 34: 161–218.Google Scholar
Thode J, Juul-Jorgensen B, Seibaek M, Elming H, Borresen E, Jordal R. Evaluation of an ionized magnesium-pH analyser-NOVA8. Scand J Lab Invest 1998; 58: 127–133.Google Scholar
Jelicks LA, Weaver J, Pollack S, Gupta RK. NMR studies of intracellular free calcium, free magnesium and sodium in the guinea pig reticulocyte and mature red cell. Biochim Biophys Acta 1989; 15: 261–266.Google Scholar
Carroll RG, Kerrigan DC, Bray JT, Foil MB, Cunningham PR. Increase in renal magnesium overflow following aortotomy induced hemorrhage in pigs. Circ Shock 1992; 32: 103–107.Google Scholar