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Do intracellular, extracellular or urinary magnesium concentrations predict renal retention of magnesium in critically ill patients?

Published online by Cambridge University Press:  13 April 2005

P. Saur ,
P. D. Niedmann ,
E. Brunner  and
D. Kettler
P. Saur
Affiliation:
Georg-August-University of Goettingen, Department of Anesthesiology, Emergency- and Intensive-Care-Medicine, Goettingen, Germany
P. D. Niedmann
Affiliation:
Georg-August-University of Goettingen, Department of Clinical Chemistry, Goettingen, Germany
E. Brunner
Affiliation:
Georg-August-University of Goettingen, Department of Medical Statistics, Goettingen, Germany
D. Kettler
Affiliation:
Georg-August-University of Goettingen, Department of Anesthesiology, Emergency- and Intensive-Care-Medicine, Goettingen, Germany
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Abstract

Summary

Background and objective: Magnesium disorders are common in hospitalized patients. In patients with low or normal magnesium, the intravenous magnesium loading test has been demonstrated to be a sensitive test to assess magnesium deficiency in critically ill patients. However, it is more time consuming and more difficult than the measurement of intracellular or extracellular magnesium concentrations. This study evaluated whether erythrocyte, plasma and urinary magnesium concentrations predict renal magnesium retention measured by the magnesium loading test.

Methods: One-hundred-and-three intensive care patients (36 females, 67 males) in a tertiary care centre and 41 healthy subjects (13 females, 28 males) took part in this prospective study. Intracellular, total plasma, ionized extracellular and urinary magnesium concentrations were measured and also magnesium retention by intravenous magnesium loading test.

Results: Total plasma magnesium concentration was poorly correlated with magnesium retention (r = 0.36, r2 = 0.13) and was the only parameter that significantly predicted magnesium retention in intensive care patients (P < 0.01). However, only 10% of the magnesium retention data were linked to the total plasma magnesium concentration.

Conclusions: Total plasma magnesium concentration predicts magnesium retention in critically ill intensive care patients but not intracellular and urinary magnesium concentrations. Only a small proportion of the magnesium retention was due to the total plasma magnesium concentration.

Keywords

MAGNESIUM, hypomagnesaemia, plasma concentrationsMAGNESIUM DEFICIENCY, magnesium excretionCRITICAL CARE
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 22 , Issue 2 , February 2005 , pp. 148 - 153
Copyright
2005 European Society of Anaesthesiology

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