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The effect of suxamethonium on intracranial pressure and cerebral perfusion pressure in patients with severe head injuries following blunt trauma

Published online by Cambridge University Press:  04 August 2006

M. M. Brown ,
M. J. A. Parr  and
A. R. Manara
M. M. Brown
Affiliation:
Department of Anaesthesia, Frenchay Hospital, Bristol, UK
M. J. A. Parr
Affiliation:
Sir Humphry Davy Department of Anaesthesia, Bristol Royal Infirmary, Bristol, UK
A. R. Manara
Affiliation:
Department of Anaesthesia, Frenchay Hospital, Bristol, UK
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Abstract

Eleven adult patients with severe head injuries caused by blunt trauma, (Glasgow Coma Score of eight or less after resuscitation), were studied while being mechanically ventilated and sedated in the intensive care unit (ICU). In a double blind randomized cross over trial each patient received a bolus of suxamethonium (1 mg kg−1) or an equal volume of saline(0.02 mL kg−1) before planned physiotherapy. Intracranial pressure (ICP) and mean arterial pressure(MAP) were measured continuously for 10 min after each injection. There were no significant changes in intracranial pressure or cerebral perfusion pressure(CPP) following the administration of suxamethonium or saline. Suxamethonium appears to be a safe drug to use on sedated persons with severe head injuries following blunt trauma.

Keywords

pressureintracranialcerebral perfusionmuscle relaxantsuxamethonium
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 13 , Issue 5 , May 1996 , pp. 474 - 477
Copyright
1996 European Society of Anaesthesiology

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