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Effective dose of granisetron for the prevention of post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy

Published online by Cambridge University Press:  16 August 2006

Y. Fujii ,
Y. Saitoh ,
H. Tanaka  and
H. Toyooka
Y. Fujii
Affiliation:
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan
Y. Saitoh
Affiliation:
Department of Anaesthesiology and Critical Care Medicine, Tokyo Medical and Dental University School of Medicine, Bunkyo-ku, Tokyo, Japan
H. Tanaka
Affiliation:
Department of Anaesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan
H. Toyooka
Affiliation:
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan
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Abstract

This study was undertaken to determine the minimum effective dose of granisetron, a selective 5-hydroxy-tryptamine type 3 receptor antagonist, for the prevention of post-operative nausea and vomiting (PONV) in female patients undergoing elective laparoscopic cholecystectomy. In randomized, placebo-controlled, double-blind study, 120 women were assigned to receive either placebo (saline) or granisetron at three different doses (20 μg kg−1, 40 μg kg−1 or 80 μg kg−1) intravenously immediately before the induction of anaesthesia. All patients received standardized aesthesia consisting of isoflurane and nitrous oxide in oxygen. The incidence of PONV during the first 24 hours after anaesthesia was 43, 40, 13 and 13% after administration of placebo and granisetron 20 μg kg−1, 40 μg kg−1 and 80 μg kg−1, respectively (P<0.05, overall Fisher's exact probability test). Adverse effects post-operatively were not different among the groups. In conclusion, granisetron 40 μg kg−1 is the minimum effective dose in the prevention of PONV after laparoscopic cholecystectomy.

Keywords

complicationsnauseavomitingdrugsantiemeticsgranisetronsurgerylaparoscopic cholecystectomy
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 15 , Issue 3 , May 1998 , pp. 287 - 291
Copyright
1998 European Society of Anaesthesiology

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