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The influence of several intravenous anaesthetics on the chemotaxis of human monocytes in vitro

Published online by Cambridge University Press:  16 August 2006

W. Krumholz ,
D. Reussner  and
G. Hempelmann
W. Krumholz
Affiliation:
Department of Anaesthesiology and Intensive Care Medicine, Justus-Liebig-University, Giessen, Germany
D. Reussner
Affiliation:
Department of Anaesthesiology and Intensive Care Medicine, Justus-Liebig-University, Giessen, Germany
G. Hempelmann
Affiliation:
Department of Anaesthesiology and Intensive Care Medicine, Justus-Liebig-University, Giessen, Germany
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Abstract

Monocytes play a very important part in humoral as well as in cell-mediated immunity. At present, however, the knowledge of the influence of anaesthetic agents on the functions of monocytes is limited. In the present study, the effects of thiopentone, methohexitone, ketamine, midazolam, droperidol, propofol, etomidate, and fentanyl on monocyte chemotaxis were examined in vitro using a 48-well microchemotaxis chamber. Clinically relevant concentrations of ketamine, midazolam, and droperidol significantly (P≤0.05) inhibited chemotaxis. For that reason, it is possible that these anaesthetics impair the immunological system in vivo. This possibility should be further examined.

Keywords

intravenous anaestheticschemotaxismonocytes
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 16 , Issue 8 , August 1999 , pp. 547 - 549
Copyright
1999 European Society of Anaesthesiology

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