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Preoperative oral celecoxib versus preoperative oral rofecoxib for pain relief after thyroid surgery

Published online by Cambridge University Press:  11 July 2005

B. Karamanlıoğlu ,
C. Arar ,
A. Alagöl ,
A. Çolak ,
I. Gemlik  and
N. Süt
B. Karamanlıoğlu
Affiliation:
Trakya University Faculty of Medicine, Department of Anaesthesiology and Reanimation, Edirne, Turkey
C. Arar
Affiliation:
Trakya University Faculty of Medicine, Department of Anaesthesiology and Reanimation, Edirne, Turkey
A. Alagöl
Affiliation:
Trakya University Faculty of Medicine, Department of Anaesthesiology and Reanimation, Edirne, Turkey
A. Çolak
Affiliation:
Trakya University Faculty of Medicine, Department of Anaesthesiology and Reanimation, Edirne, Turkey
I. Gemlik
Affiliation:
Trakya University Faculty of Medicine, Department of Anaesthesiology and Reanimation, Edirne, Turkey
N. Süt
Affiliation:
Trakya University Faculty of Medicine, Department of Biostatistics, Edirne, Turkey
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Extract

Summary

Background and objective: The study compared the analgesic efficacy and safety of two preoperatively administered cyclo-oxygenase-2 inhibitors, celecoxib and rofecoxib.

Methods: Ninety adult patients undergoing thyroid surgery were divided into three groups (each n = 30). They were given a single oral dose of placebo, celecoxib 200 mg or rofecoxib 50 mg 1 h before induction of anaesthesia. All patients received a standard anaesthetic. Intraoperative blood loss was measured. Pain scores, sedation scores, heart rate, mean arterial pressure and respiratory rate were noted at 0, 1, 2, 4, 6, 12 and 24 h postoperatively. Analgesic (meperidine) requirements and adverse effects were recorded during the first postoperative 24 h.

Results: Compared with placebo, pain scores were significantly lower with rofecoxib at all time points (P < 0.05) and were significantly lower with celecoxib (P < 0.05) during the first 4 h. Pain scores were significantly lower with rofecoxib compared with celecoxib at 6, 12 and 24 h (P < 0.05). The average cumulative 24 h meperidine dose was significantly lower with both celecoxib (54.9 ± 34.4 mg) and rofecoxib (42.8 ± 40.9 mg) compared with placebo (76.8 ± 6.2 mg) (P < 0.01 and P < 0.001, respectively). There were no differences in the intraoperative blood loss, heart rate, mean arterial pressure, respiratory rate, sedation scores and incidence of adverse effects among groups.

Conclusions: The preoperative administration of rofecoxib 50 mg and less so of celecoxib 200 mg provide a significant analgesic benefit with regard to postoperative pain relief and decrease in additional opioid requirements after thyroid surgery.

Keywords

ANALGESIC TECHNIQUES, preoperativeANALGESICS, NON-OPIOID, celecoxib, paracetamol, rofecoxibANALGESICS, OPIOID, meperidinePAIN, postoperativeSURGERY, thyroid
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 20 , Issue 6 , June 2003 , pp. 490 - 495
Copyright
© 2003 European Society of Anaesthesiology

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