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Pulse dye densitometry using indigo carmine is useful for cardiac output measurement, but not for circulating blood volume measurement

Published online by Cambridge University Press:  23 December 2004

Y. Fujita ,
T. Yamamoto ,
M. Fuse ,
N. Kobayashi ,
S. Takeda  and
T. Aoyagi
Y. Fujita
Affiliation:
Kawasaki Medical School, Department of Anesthesiology and ICM, Okayama, Tokyo, Japan
T. Yamamoto
Affiliation:
Kawasaki Medical School, Department of Urology, Okayama, Tokyo, Japan
M. Fuse
Affiliation:
Research and Development Laboratory, Nihon Kohden Co., Tokyo, Japan
N. Kobayashi
Affiliation:
Research and Development Laboratory, Nihon Kohden Co., Tokyo, Japan
S. Takeda
Affiliation:
Research and Development Laboratory, Nihon Kohden Co., Tokyo, Japan
T. Aoyagi
Affiliation:
Research and Development Laboratory, Nihon Kohden Co., Tokyo, Japan
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Abstract

Summary

Background and objective: We evaluated the validity of a newly developed pulse dye densitometer for indigo carmine for measuring cardiac output and circulating blood volume.

Methods: Measurements of cardiac output and circulating blood volume were performed with the indigo carmine densitometer during normovolaemia, hypovolaemia and hypervolaemia in nine mongrel dogs under general anaesthesia. The validity was evaluated by comparison of the values of cardiac output and circulating blood volume obtained by the thermodilution technique and the 51Cr-labelled red blood cell method, respectively. We also examined indigo carmine removal by continuous veno-venous haemofiltration after indigo carmine injection.

Results: There was good agreement between dye densitometer- and thermodilution-derived cardiac output (r = 0.885, P < 0.001). The bias and limits of agreement of these values were 0.09 and ± 1.07L min−1 (2 SD, n = 22), respectively. The dye-densitometer-derived circulating blood volume was greater than that of the 51Cr-labelled red blood cell method, and both values showed weak agreement (r = 0.587, P < 0.027). The sieving coefficient of indigo carmine through continuous veno-venous haemofiltration was 0.34 ± 0.06.

Conclusions: These data indicate that indigo carmine densitometry is a reliable method for cardiac output determination, but it overestimates circulating blood volume, probably due to the transition of indigo carmine into the extravascular space in the systemic circulation.

Keywords

CARDIAC OUTPUTDIAGNOSTIC TECHNIQUES, cardiovascular, blood volume determinationINVESTIGATIVE TECHNIQUESindicator-dilution technique, dye-dilution technique, indigo carmine
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 21 , Issue 8 , August 2004 , pp. 632 - 637
Copyright
2004 European Society of Anaesthesiology

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References

Joel AB, Mueller MD, Pahira JJ, Mordkin RM. Nonvisualization of intravenous methylene blue in patients with clinically normal renal function. Urology 2001; 58: 607.Google Scholar
Imai T, Takahashi K, Fukura H, Morishita Y. Measurement of cardiac output by pulse dye densitometry using indocyanine green: a comparison with the thermodilution method. Anesthesiology 1997; 87: 816–822.Google Scholar
Iijima T, Iwao Y, Sankawa H. Circulating blood volume measured by pulse dye-densitometry. Comparison with (131)-I HSA analysis. Anesthesiology 1998; 89: 1329–1335.Google Scholar
Iijima T, Aoyagi A, Iwao Y, et al. Cardiac output and circulating blood volume analysis by pulse dye-densitometry. J Clin Monit 1997; 13: 81–89.Google Scholar
Aoyagi T, Miyasaka K. The theory and applications of pulse spectrophotometry. Anesth Analg 2002; 94: S93–S95.Google Scholar
International Committee for Standardization in Haematology. Recommended methods for measurement of red-cell and plasma volume. N Nucl Med 1980; 21: 793–800.
Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; i: 307–310.Google Scholar
Lacy WW, Ugaz C, Newman EV. The use of indigo carmine for dye dilution curves. Circ Res 1955; 3: 570–574.Google Scholar
van Grondelle A, Ditchey RV, Groves BM, Wagner WW Jr, Reeves JT. Thermodilution method overestimates low cardiac output in humans. Am J Physiol 1983; 245: H690–H692.Google Scholar
Weisel RD, Berger RL, Hechtman HB. Current concepts measurement of cardiac output by thermodilution. New Engl J Med 1975; 292: 682–684.Google Scholar
Baker KJ. Binding of sulfobromophthalein (BSP) sodium and indocyanine green (ICG) by plasma alpha-1 lipoproteins. Proc Soc Exp Biol Med 1966; 122: 957–963.Google Scholar
Hirszel P, Shea-Donohue T, Chakrabarti E, Montcalm E, Maher JF. The role of the capillary wall in restricting diffusion of macromolecules. A study of peritoneal clearance of dextrans. Nephron 1988; 49: 58–61.Google Scholar
Nguyen AC, Kost E, Framstad M. Indigo carmine-induced severe hypotension. Anesth Analg 1998; 87: 1194–1195.Google Scholar
Harioka T, Mori H, Mori K. Hypertensive reaction to indigo carmine during transurethral resection of a bladder tumor. Anesth Analg 1987; 66: 1049.Google Scholar