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Trazodone hydrochloride attenuates thermal hyperalgesia in a chronic constriction injury rat model

Published online by Cambridge University Press:  30 June 2005

K. Okuda ,
T. Takanishi ,
K. Yoshimoto  and
S. Ueda
K. Okuda
Affiliation:
Dokkyo University School of Medicine, Department of Anaesthesiology, Mibu, Tochigi, Japan Dokkyo University School of Medicine, Department of Histology and Neurobiology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
T. Takanishi
Affiliation:
Dokkyo University School of Medicine, Department of Anaesthesiology, Mibu, Tochigi, Japan
K. Yoshimoto
Affiliation:
Kyoto Prefectural University of Medicine, Department of Legal Medicine, Kawaramachi-Hirokoji, Kamikyo-ku, Kyoto, Japan
S. Ueda
Affiliation:
Dokkyo University School of Medicine, Department of Histology and Neurobiology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
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Extract

Summary

Background and objective: Trazodone hydrochloride is used in the treatment of neuropathic pain. However, the analgesic effects of trazodone on neuropathic pain are controversial. The study was undertaken to determine the analgesic effect of trazodone on a chronic constriction injury model.

Methods: We tested the effect of trazodone on thermal hyperalgesia due to a chronic constriction injury of the sciatic nerve in rats and examined the effects of lesions in the descending and ascending serotonergic system induced by 5,7-dihydroxytriptamine (5,7-DHT).

Results: The analgesic effects of trazodone showed a clear dose dependency. Furthermore, the analgesic effect of trazodone was observed in rats injected with 5,7-DHT into the dorsal raphe nucleus and medial raphe nucleus.

Conclusions: The results suggest that a mainly serotonergic descending pain control pathway mediates the analgesic effects of trazodone.

Keywords

ANTIDEPRESSIVE AGENTS, SECOND-GENERATION, trazodoneINVESTIGATIVE TECHNIQUES, models, animalNERVOUS SYSTEM PHYSIOLOGY, SENSATION, painSOMATOSENSORY DISORDERS, hyperalgesia
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 20 , Issue 5 , May 2003 , pp. 409 - 415
Copyright
2003 European Society of Anaesthesiology

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