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Clinical measures of rapid onset of action

Published online by Cambridge University Press:  16 April 2020

SA Montgomery
SA Montgomery*
Affiliation:
Department of Pharmacology, Imperial College School of Medicine at St Mary's, Norfolk Place, London, W2 1NY, UK
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Summary

The benefits of an antidepressant with an early or rapid onset of action include a more rapid resolution of the debilitating symptoms of depression, a potential reduction in the risk of suicide and cost savings associated with a reduction in hospitalization. While these benefits are valuable, this promise has yet to be fulfilled by any antidepressant. Venlafaxine is a unique serotonin-noradrenaline reuptake inhibitor (SNRI) which produces rapid and prolonged desensitization of β-adrenergic receptors in preclinical studies after both acute and chronic administration of venlafaxine. Results from placebo-controlled and active comparator clinical studies provide evidence that venlafaxine may have an early onset of activity which is most apparent at higher dosages. The early onset is most apparent with rapid escalation of the venlafaxine dosage, and the incidence, therefore, of side effects tends to be higher early after initiating therapy with venlafaxine. Thus, venlafaxine may fill the long awaited need for an antidepressant with an early onset of action.

Keywords

antidepressantsvenlafaxineserotonin-noradrenaline reuptake inhibitorclinical pharmacologyonset of action
Type
Research Article
Information
European Psychiatry , Volume 12 , Issue S4 , 1997 , pp. 295s - 300s
Copyright
Copyright © Elsevier, Paris 1997

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