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Antidepressant therapy is followed by normalization 0f serum albumin conformation in patients with melancholic depression

Published online by Cambridge University Press:  23 March 2020

T. Syrejshchikova ,
N. Smolina ,
M. Uzbekov ,
G. Dobretsov ,
V. Krjukov ,
V. Brilliantova  and
V. Krasnov
T. Syrejshchikova
Affiliation:
Lebedev physical institute, high energy, Moscow, Russia
N. Smolina
Affiliation:
Research and clinical center of physical-chemical medicine, medical biophysics, Moscow, Russia
M. Uzbekov
Affiliation:
Moscow research institute of psychiatry, brain pathology, Moscow, Russia
G. Dobretsov
Affiliation:
Research and clinical center of physical-chemical medicine, medical biophysics, Moscow, Russia
V. Krjukov
Affiliation:
Moscow research institute of psychiatry, affective disorders, Moscow, Russia
V. Brilliantova
Affiliation:
Research and clinical center of physical-chemical medicine, medical biophysics, Moscow, Russia
V. Krasnov
Affiliation:
Moscow research institute of psychiatry, affective disorders, Moscow, Russia

Abstract

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Objectives

Discovery of biomarkers for evaluation of efficacy of psychopharmacotherapy is important task.

Aim

To study parameters characteristic for albumin binding sited in melancholic depression (MD) using fluorescent laser spectroscopy in range of 30–50 picoseconds.

Methods

22 patients with MD (dep) (F33.1 and 2) were investigated in dynamics of antidepressant therapy (venlafaxine: 75–150 mg/daily) for 30 days. Control group (con) consists of 54 volunteers. Decay of fluorescence amplitude (A) of fluorescent probe K-35 from serum albumin was measured using laser. Earlier, we revealed 3 binding sites in albumin with amplitudes A1, A2 and A3 with decay time of 1, 3 and 9 nanoseconds, respectively.

Results

There was revealed significant decrease of amplitude A1dep, normalized on mean value of A1 for controls (A1dep/A1con), for patients with MD after treatment with venlafaxine. In this case, A1depvalues decreased and were equal to A1 values of controls (P < 0.01): A1dep/A1con before treatment–1.23 and after 30 days of therapy–0.97 relative units; for controls this value was–1.00 relative units. The same type of normalization was observed for amplitudes A2 and A3 of melancholic patients. There were revealed significant changes of A3/A1 ratio that points out on conformational changes of serum albumin molecule in dynamics of venlafaxine therapy.

Conclusion

We have registered unidirectional changes in albumin molecule in patients with MD. Investigated parameters can serve as potential biomarkers for evaluation of efficacy of psychopharmacotherapy.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Walk: Depression - part 3 and obsessive-compulsive disorder
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S327
Copyright
Copyright © European Psychiatric Association 2017
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