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Antineuronal Antibodies in Obsessive-compulsive Disorder: Comparisons in Children with OCD-only, OCD + Chronic tics and OCD + PANDAS

Published online by Cambridge University Press:  16 April 2020

H. Singer ,
C. Gause  and
M. Grados
H. Singer
Affiliation:
Johns Hopkins University, Baltimore, USA
C. Gause
Affiliation:
Johns Hopkins University, Baltimore, USA
M. Grados
Affiliation:
Johns Hopkins University, Baltimore, USA

Abstract

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We will present a comparison of serum antineuronal antibody profiles in children with OCD-only (n=13), PANDAS + OCD (n=20), CTD + OCD (n=23), and age-matched controls (n=29). Detection methods used to evaluate anti-brain antibodies included immunohistochemistry (striatum), ELISA (BA 9/10, BA 11, caudate, and cingulate gyrus), and Western immunoblotting (BA 9/10, BA 11, caudate, and cingulate gyrus).

Immunublotting was further used to assess the presence and concentration of putative antigens identified in post-streptococcal patients, i.e., *- and *-enolase, aldolase C, pyruvate kinase M1 and tubulin. Anti-lysoganglioside GM1 activity was measured by competitive inhibition.

Type
S34-01
Information
European Psychiatry , Volume 24 , Issue S1: 17th EPA Congress - Lisbon, Portugal, January 2009, Abstract book , January 2009 , 24-E175
Copyright
Copyright © European Psychiatric Association 2009
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