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Association analysis of the insertion/deletion polymorphism in serotonin transporter gene in patients with affective disorder

Published online by Cambridge University Press:  16 April 2020

Joanna Hauser ,
Anna Leszczyńska ,
Jerzy Samochowiec ,
Piotr M. Czerski ,
Agata Ostapowicz ,
Maria Chlopocka ,
Jan Horodnicki  and
Janusz K. Rybakowski
Joanna Hauser*
Affiliation:
Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland
Anna Leszczyńska
Affiliation:
Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland
Jerzy Samochowiec
Affiliation:
Department of Psychiatry, Pomeranian Academy of Medicine, Szczecin, Poland
Piotr M. Czerski
Affiliation:
Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland
Agata Ostapowicz
Affiliation:
Department of Psychiatry, Pomeranian Academy of Medicine, Szczecin, Poland
Maria Chlopocka
Affiliation:
Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland
Jan Horodnicki
Affiliation:
Department of Psychiatry, Pomeranian Academy of Medicine, Szczecin, Poland
Janusz K. Rybakowski
Affiliation:
Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland
*
*Email: j.hauser@wp.pl
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Abstract

A polymorphism of serotonin transporter was studied in 226 patients with affective disorders (n = 132 for bipolar, n = 94 for unipolar affective disorder) and in 213 healthy subjects. Consensus diagnosis by at least two psychiatrists, according to the ICD-10 and DSM-IV criteria was made for each patient using SCID (Structured Clinical Interview for DSM-IV Axis I Disorders). A functional polymorphism in the promoter region of serotonin transporter gene, where 44 bp are either inserted (long allele) or deleted (short allele) was analysed. Genotype s/s was significantly more frequent in patients comparing to the control group (P = 0.011 for bipolar and P = 0.003 for unipolar affective disorder) - the most marked association was found in males with bipolar and unipolar illness. The allele frequencies also differ significantly between patients and controls (P = 0.003 for bipolar and P = 0.001 for unipolar affective disorder). The frequency of the low activity (short) allele was higher in patients than in controls (51.1% in bipolar, and 54.3 in unipolar vs 39.4% in controls). We suggest that the presence of allele s may increase the susceptibility to occurrence of affective disorder.

Keywords

PolymorphismSerotoninAffective disorders
Type
Short communication
Information
European Psychiatry , Volume 18 , Issue 3 , May 2003 , pp. 129 - 132
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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