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Association study between glucocorticoid receptor polymorphisms and personality traits in healthy subjects

Published online by Cambridge University Press:  16 April 2020

Y. Matsumoto ,
A. Suzuki ,
N. Shibuya ,
R. Sadahiro ,
M. Kamata ,
K. Goto  and
K. Otani
Y. Matsumoto
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
A. Suzuki
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
N. Shibuya
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
R. Sadahiro
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
M. Kamata
Affiliation:
Health Administration Center, Yamagata University, Yamagata, Japan
K. Goto
Affiliation:
Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata, Japan
K. Otani
Affiliation:
Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan

Abstract

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Aims

Previous studies have shown that the function of hypothalamic-pituitary-adrenal (HPA) axis is involved in the characterization of personality traits. Glucocorticoid receptor (GR) is the most important regulator of the HPA axis negative feedback system, and several polymorphisms of the GR gene are associated with altered glucocorticoid sensitivity. In the present study, we examined the associations between the GR polymorphisms and personality traits in healthy subjects.

Methods

Subjects were 880 Japanese healthy volunteers. Personality traits were assessed by the Temperament and Character Inventory (TCI). Two polymorphisms of the GR gene, i.e., G/C SNP in the intron 2 (BcII polymorphism, rs41423247) and A/G SNP in the exon 9β (9β polymorphism, rs6198), were detected by a real-time PCR and cycling probe technology for SNP typing.

Results

The genotype distributions were G/G = 614, G/C = 240, and C/C = 26 for the BcII polymorphism, and A/A = 879 and A/G = 1 for the 9β polymorphism, respectively. There were no significant associations between the BcII genotype groups in any TCI dimension score.

Conclusion

The present study suggests that these two GR polymorphisms (BcII and 9β polymorphism) are not involved in the characterization of personality traits in healthy subjects.

Type
P02-213
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 809
Copyright
Copyright © European Psychiatric Association 2011
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