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Associations among immune activation, the clinical characteristics, and the current severity of the “with anxious distress” specifier in patients with depressive disorders

Published online by Cambridge University Press:  23 March 2020

W.M. Bahk ,
I.H. Shim ,
Y.S. Woo ,
S.Y. Lee ,
Y.J. Kwon ,
D.I. Jon ,
H.J. Seo ,
B.W. Nam  and
J.S. Seo
W.M. Bahk*
Affiliation:
Yeouido St. Mary's Hospital, psychiatry, Seoul, Republic of Korea
I.H. Shim
Affiliation:
Dongnam Institute of Radiological & Medical Sciences, psychiatry, Busan, Republic of Korea
Y.S. Woo
Affiliation:
Yeouido St. Mary's Hospital, psychiatry, Seoul, Republic of Korea
S.Y. Lee
Affiliation:
Wonkwang University School of Medicine, psychiatry, Iksan, Republic of Korea
Y.J. Kwon
Affiliation:
Soonchunhyang Cheonan Hospital, psychiatry, Cheonan, Republic of Korea
D.I. Jon
Affiliation:
Sacred Heart Hospital, Hallym University, psychiatry, Anyang, Republic of Korea
H.J. Seo
Affiliation:
Yeouido St. Mary's Hospital, psychiatry, Seoul, Republic of Korea
B.W. Nam
Affiliation:
Konkuk University, Chungju Hospital, psychiatry, Chungju, Republic of Korea
J.S. Seo
Affiliation:
Konkuk University, Chungju Hospital, psychiatry, Chungju, Republic of Korea
*
*Corresponding author.

Abstract

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Introduction

This study assessed the levels of immune factors, demographic and clinical characteristics, and pharmacological treatments of patients with depressive disorders and compared them between patients with mild-to-moderate and moderate/severe-to-severe anxiety.

Methods

This study included 177 patients diagnosed with a depressive disorder who were hospitalized between March 2012 and April 2015. The patients were categorized into mild-to-moderate anxious distress and moderate/severe-to-severe anxious distress groups, based on the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) based on the “with anxious distress” specifier. The current severity of symptoms was determined using the Hamilton Depression Rating Scale (HAM-D) scores on the Agitation and Anxiety-Psychic subscales. The charts of the patients were reviewed to evaluate immune factors, including C-reactive protein (CRP) and white blood cell (WBC) levels, confounding factors, such as smoking, other general medical disorders, and body mass index (BMI), and demographic and clinical characteristics.

Results

The moderate–severe to severe anxious distress group tended to have higher CRP and monocyte levels compared with the mild to moderate anxious distress group. However, after adjusting for the total HAM-D scores, there was a significant difference only in monocyte levels. After this adjustment, patients with moderate–severe to severe anxious distress had a significantly greater trend toward significance for suicidality and a higher rate of antipsychotic use.

Conclusions

High levels of anxiety symptoms may influence various underlying pathophysiological factors and modulate the inflammatory response and course of illness, affecting treatment planning.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV480
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S405 - S406
Copyright
Copyright © European Psychiatric Association 2016
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