Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-13T01:38:44.440Z Has data issue: false hasContentIssue false
  • English
  • Français

Basal ganglia calcification and psychosis in 22q11.2 deletion syndrome

Published online by Cambridge University Press:  16 April 2020

M. Sieberer ,
H. Haltenhof ,
B. Haubitz ,
B. Pabst ,
K. Miller  and
P. Garlipp
M. Sieberer*
Affiliation:
Department of Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625Hannover, Germany
H. Haltenhof
Affiliation:
Department of Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625Hannover, Germany
B. Haubitz
Affiliation:
Department of Neuroradiology, Hannover Medical School, Hannover, Germany
B. Pabst
Affiliation:
Department of Human Genetics, Hannover Medical School, Hannover, Germany
K. Miller
Affiliation:
Department of Human Genetics, Hannover Medical School, Hannover, Germany
P. Garlipp
Affiliation:
Department of Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625Hannover, Germany
*
*Corresponding author. E-mail address: Sieberer.Marcel@mh-hannover.de (M. Sieberer).
Get access

Abstract

Intracerebral calcifications are a facultative symptom of hypoparathyreoidism in 22q11.2 deletion syndrome (22qDS). We describe a patient with 22qDS, basal ganglia calcification (BGC) and psychotic symptoms and discuss the etiological connection of BGC with psychiatric symptoms. Future work needs to determine the prevalence of BGC in 22qDS and psychiatric disorders.

Keywords

Basal ganglia calcification22q11 DeletionPsychosisSchizophreniaVelocardiofacial syndromeDiGeorge syndrome
Type
Short communication
Information
European Psychiatry , Volume 20 , Issue 8 , December 2005 , pp. 567 - 569
Copyright
Copyright © Elsevier SAS 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Chow, EWCMikulis, DJZipursky, RBScutt, LEWeksberg, RBassett, ASQualitative MRI findings in adults with 22q11 deletion syndrome and schizophrenia. Biol. Psychiatry 1999;46(10):1436–1442.10.1016/S0006-3223(99)00150-XCrossRefGoogle Scholar
Cummings, JLGosenfeld, LFHoulihan, JPMccaffrey, TNeuro-psychiatric disturbances associated with idiopathic calcification of the basal ganglia. Biol Psychiatry 1983;18(5):591–601.Google Scholar
Eliez, SBarnea-Goraly, NSchmitt, JELiu, YReiss, ALIncreased basal ganglia volumes in velo-cardio-facial syndrome (deletion 22q11.2). Biol Psychiatry 2002;52(1):68–70.10.1016/S0006-3223(02)01361-6CrossRefGoogle Scholar
Eliez, SBlasey, CMSchmitt, EJWhite, CDHu, DReiss, ALVelocardiofacial syndrome: are structural changes in the temporal and mesial temporal regions related to schizophrenia?. Am J Psychiatry 2001;158(3):447–453.10.1176/appi.ajp.158.3.447CrossRefGoogle Scholar
Flint, JGoldstein, LHFamilial calcification of the basal ganglia: a case-report and review of the literature. Psychol Med 1992;22(3):581–595.10.1017/S0033291700038046CrossRefGoogle ScholarPubMed
Horowitz, AShifman, SRivalin, NPisante, ADarvasi, AA survey of the 22q11 microdeletion in a large cohort of schizophrenia patients. Schizophr Res 2005;73: 263–267.10.1016/j.schres.2004.02.008CrossRefGoogle Scholar
Murphy, KCSchizophrenia and velocardio-facial syndrome. Lancet 2002;359: 426–430.10.1016/S0140-6736(02)07604-3CrossRefGoogle Scholar
Murphy, KCJones, LAOwen, MJHigh rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry 1999;56: 940–945.10.1001/archpsyc.56.10.940CrossRefGoogle ScholarPubMed
Óskarsdóttir, SVujic, MFasth, AIncidence and prevalence of the 22q11 deletion syndrome: a population-based study in Western Sweden. Arch Dis Child 2004;89: 148–152.10.1136/adc.2003.026880CrossRefGoogle ScholarPubMed
Sciré, GDallapiccola, BIannetti, PBonaiuto, FGalasso, CMingarelli, Ret al.Hypoparathyroidism as the major manifestation in two patients with 22q11 deletions. Am J Med Genet 1994;52(4):478–482.10.1002/ajmg.1320520415CrossRefGoogle ScholarPubMed
Shprintzen, RJGoldberg, RGolding-Kushner, KJMarion, RWLate-onset psychosis in the velo-cardio-facial syndrome. Am J Med Genet 1992;42(1):141–142.10.1002/ajmg.1320420131CrossRefGoogle ScholarPubMed
Shprintzen, RJGoldberg, RBLewin, MLSidoti, EJBerkman, MDArgamaso, RVet al.A new syndrome involving cleft palate, cardiac anomalies, typical facies, and learning disabilities: velo-cardio-facial syndrome. Cleft Palate J 1978;15(1):56–62.Google ScholarPubMed
Simon, TJDing, LBish, JPMcDonnald-McGinn, DMZackai, EHGee, JVolumetric, connective, and morphologic changes in the brains of children with chormosome 22q11.2 deletion syndrome: an integrative study. Neuroimage 2005;25: 169–180.10.1016/j.neuroimage.2004.11.018CrossRefGoogle Scholar
Van Amelsvoort, TDaly, EHenry, JRobertson, DNg, VOwen, Met al.Brain anatomy in adults with velocardiofacial syndrome with and without schizophrenia. Arch Gen Psychiatry 2004;61: 1085–1096.10.1001/archpsyc.61.11.1085CrossRefGoogle ScholarPubMed
Van Amelsvoort, TDaly, ERobertson, DSuckling, JNg, VCritchley, Het al.Structural brain abnormalities associated with deletion at chromosome 22q11—quantitative neuroimaging study of adults with velo-cardio-facial syndrome. Br J Psychiatry 2001;178: 412–419.10.1192/bjp.178.5.412CrossRefGoogle ScholarPubMed
Wilson, DIBurn, JScambler, PGoodship, JDiGeorge syndrome: part of CATCH 22. J Med Genet 1993;30(10):852–856.10.1136/jmg.30.10.852CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.