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Characteristics of responders and non-responders to risperidone monotherapy or placebo in co-occurring bipolar disorder and anxiety disorder

Published online by Cambridge University Press:  29 November 2011

J.S. Seo ,
K. Jamieson ,
V. Cosgrove ,
I.S. Gwizdowski ,
H. Yang ,
D.V. Sheehan ,
S.L. McElroy  and
T. Suppes
J.S. Seo
Affiliation:
Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, VA Palo Alto Health Care System, 3801, Miranda Avenue (151T), Palo Alto, CA94304, USA Department of Psychiatry, College of Medicine, Konkuk University Chung-Ju Hospital, 620-5, Kyohyun 2 dong, Chungju-city, Chungbuk-Do, South Korea
K. Jamieson
Affiliation:
33, Mills Canyon Ct, Burlingame, CA94010, USA
V. Cosgrove
Affiliation:
Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, VA Palo Alto Health Care System, 3801, Miranda Avenue (151T), Palo Alto, CA94304, USA
I.S. Gwizdowski
Affiliation:
Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, VA Palo Alto Health Care System, 3801, Miranda Avenue (151T), Palo Alto, CA94304, USA
H. Yang
Affiliation:
Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, VA Palo Alto Health Care System, 3801, Miranda Avenue (151T), Palo Alto, CA94304, USA
D.V. Sheehan
Affiliation:
University of South Florida, USF Institute for Research in Psychiatry, 3515, East Fletcher Avenue, Tampa, FL33613, USA
S.L. McElroy
Affiliation:
Research Institute, Lindner Center of HOPE, University of Cincinnati Medical Center, 4075, Old Western Row Road, Mason, OH45040, USA Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA
T. Suppes*
Affiliation:
Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, VA Palo Alto Health Care System, 3801, Miranda Avenue (151T), Palo Alto, CA94304, USA
*
⁎Corresponding author. Tel.: +650 493 5000x62567; fax: +650 849 1913. E-mail address:tsuppes@stanford.edu (T. Suppes).
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Abstract

Clinical characteristics predicting response and remission to psychopharmacological treatment of bipolar disorder (BD) and co-occurring anxiety disorders have been understudied. We hypothesized that non-response to risperidone or placebo in individuals with co-occurring BD and anxiety symptoms would be associated with a more severe clinical course of BD, and certain demographic variables. This study was a secondary analysis of a randomized, double-blind, parallel, 8-week study comparing risperidone monotherapy and placebo in individuals with BD plus current panic disorder, current generalized anxiety disorder (GAD), or lifetime panic disorder (n = 111) [31]. We compared clinical characteristics of responders (50% improvement on the Hamilton Anxiety Scale [HAM-A]) and non-responders as well as remitters (HAM-A < 7) and non-remitters in risperidone treatment (n = 54) and placebo (n = 57) groups. For non-responders in the risperidone group, co-occurring lifetime panic disorder was significantly more common than for non-responders in the placebo group. Apart from this, no significant differences in course of illness or demographics were found either between or across groups for patients with BD and co-occurring anxiety symptoms receiving risperidone or placebo in this acute phase study.

Keywords

Anxiety disorderBipolar disorderCo-occurringRisperidoneTreatment response
Type
Original article
Information
European Psychiatry , Volume 28 , Issue 3 , March 2013 , pp. 190 - 196
Copyright
Copyright © European Psychiatric Association 2011

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