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Clinical and functioning outcomes of second-generation long-acting antipsychotics in a sample of schizophrenia patients during a follow-up period of 6 months

Published online by Cambridge University Press:  23 March 2020

V. Corigliano ,
I. Mancinelli ,
A. De Carolis ,
S.M. Tamorri ,
S. Di Pietro ,
F. Pazzelli ,
I. Ciccaglione ,
P. Girardi  and
A. Comparelli
V. Corigliano*
Affiliation:
Sant’Andrea hospital, NESMOS department neurosciences- mental health and sense organs unit of psychiatry- Sant’Andrea hospital- school of medicine and psychology- Sapienza university, Roma, Italy
I. Mancinelli
Affiliation:
Sant’Andrea hospital, NESMOS department neurosciences- mental health and sense organs unit of psychiatry- Sant’Andrea hospital- school of medicine and psychology- Sapienza university, Roma, Italy
A. De Carolis
Affiliation:
Sant’Andrea hospital, NESMOS department neurosciences- mental health and sense organs unit of psychological medicine- Sant’Andrea hospital- school of medicine and psychology- Sapienza university, Roma, Italy
S.M. Tamorri
Affiliation:
Sant’Andrea hospital, NESMOS department neurosciences- mental health and sense organs unit of psychiatry- Sant’Andrea hospital- school of medicine and psychology- Sapienza university, Roma, Italy
S. Di Pietro
Affiliation:
Sant’Andrea hospital, NESMOS department neurosciences- mental health and sense organs unit of psychiatry- Sant’Andrea hospital- school of medicine and psychology- Sapienza university, Roma, Italy
F. Pazzelli
Affiliation:
Sant’Andrea hospital, NESMOS department neurosciences- mental health and sense organs unit of psychiatry- Sant’Andrea hospital- school of medicine and psychology- Sapienza university, Roma, Italy
I. Ciccaglione
Affiliation:
Sant’Andrea hospital, NESMOS department neurosciences- mental health and sense organs unit of psychiatry- Sant’Andrea hospital- school of medicine and psychology- Sapienza university, Roma, Italy
P. Girardi
Affiliation:
Sant’Andrea hospital, NESMOS department neurosciences- mental health and sense organs unit of psychiatry- Sant’Andrea hospital- school of medicine and psychology- Sapienza university, Roma, Italy
A. Comparelli
Affiliation:
Sant’Andrea hospital, NESMOS department neurosciences- mental health and sense organs unit of psychiatry- Sant’Andrea hospital- school of medicine and psychology- Sapienza university, Roma, Italy
*
*Corresponding author.

Abstract

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Introduction

Second-generation long-acting injectable antipsychotics (LAIs) constitute a valuable alternative for the treatment of schizophrenia and combine advantages of both long-acting injectable drugs and atypical antipsychotics. Realistic, naturalistic studies are necessary to evaluate the impact of LAIs on specific cluster of symptoms.

Objectives

To collect clinical and functioning outcomes in outpatients with schizophrenia treated with LAIs during a follow-up period of 6 months.

Aims

To determine the impact on symptoms and functioning of second-generation LAIs.

Methods

It is a 6-month naturalistic, observational, prospective, non-interventional study of patients diagnosed with DSM-V schizophrenia disorder. Clinical data were assessed by the Positive and Negative Syndrome Scale (PANSS) and the Global Assessment of Functioning (GAF). For statistical analysis, we used the Wallwork's five-factor model of the PANSS.

Results

A total of 50 schizophrenia patients (70% male; mean age: 36.2 ± 10.4) referred to the Depot Clinic at Sant’Andrea Hospital in Rome was included. Eight patients received treatment with risperidone LAI (RLAI), 20 with paliperidone-palmitate LAI (PLAI), 10 with olanzapine-pamoate LAI (OLAI) and 12 with aripiprazole LAI (ALAI). LAIs were overall associated with improved functioning and positive symptoms; OLAI, ALAI e PLAI correlated with improved negative symptoms, RLAI, OLAI e PLAI with improved disorganised/concrete symptoms, OLAI e PLAI with improved excited symptoms; ALAI improved depressive symptoms.

Conclusion

Over the 6-month period, LAIs were associated with improved functioning and illness severity in schizophrenia patients with different symptoms profile. Treatment with PLAI and OLAI showed the major clinical advantages, whereas only ALAI correlated with improved depressive symptoms.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW503
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. s245
Copyright
Copyright © European Psychiatric Association 2014
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