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C-reactive protein levels are related to suicidality in euthymic patients with bipolar disorder

Published online by Cambridge University Press:  23 March 2020

M. Pantovic Stefanovic ,
B. Dunjic-Kostic ,
M. Lackovic ,
A. Damjanovic ,
A. Jovanovic ,
S. Totic-Poznanovic  and
M. Ivkovic
M. Pantovic Stefanovic*
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia
B. Dunjic-Kostic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
M. Lackovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
A. Damjanovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
A. Jovanovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
S. Totic-Poznanovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
M. Ivkovic
Affiliation:
Clinic for Psychiatry Clinical Centre of Serbia, Department for Affective Disorders, Belgrade, Serbia University of Belgrade, School of Medicine, Belgrade, Serbia
*
* Corresponding author.

Abstract

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Introduction

Immune alterations are believed to be an important part in etiopathogenesis of affective disorders. However, it is not clear if the altered immune mediators are related to distinct disorders or particular psychopathology.

Aims

The aim of our study was to explore the differences in C-reactive protein levels (CRP) between euthymic BD patients and healthy controls, as well as to explore the relationship between CRP and lifetime presented psychopathology within BD.

Methods

The study group consisted of 83 patients diagnosed with BD, compared to the healthy control group (n = 73) and matched according to age, gender, and body mass index (BMI). Lifetime psychopathology has been assessed according to predominant polarity as well as previous history of suicide attempts and psychotic episodes.

Results

The CRP levels were significantly higher in BD patients when compared to healthy controls. After covarying for confounders, we observed that CRP levels, in euthymic BD patients, were related to number of previous suicide attempts, but not other indicators of lifetime psychopathology.

Conclusions

BD patients per se, and particularly those with more suicide attempts, are more likely to present with proinflammatory state, even when in remission. Previous history of suicide attempts could bear specifically vulnerable endophenotype within BD. Systemic, longitudinal monitoring of the course of illness, and potential inflammatory mediators that underlie its systemic nature is warranted.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV194
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S337
Copyright
Copyright © European Psychiatric Association 2016
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