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Effects of nicotine abstinence on clinical symptoms. Study at 3 and 6-months follow-up of outpatients with schizophrenia

Published online by Cambridge University Press:  23 March 2020

P.A. Sáiz Martinez ,
S. Al-Halabí ,
S. Fernández-Artamendi ,
L. García-Álvarez ,
E. Díaz-Mesa ,
E. Martínez-Santamaría ,
G. Florez ,
M. Arrojo ,
M.P. García-Portilla  and
J. Bobes
P.A. Sáiz Martinez*
Affiliation:
Universidad de Oviedo, Área de Psiquiatría - CIBERSAM, Oviedo, Spain
S. Al-Halabí
Affiliation:
Centro de Investigación Biomédica en Red de Salud Mental- CIBERSAM., Área de Psiquiatría - Universidad de Oviedo, Oviedo, Spain
S. Fernández-Artamendi
Affiliation:
Universidad de Oviedo, Facultad de Psicología, Oviedo, Spain
L. García-Álvarez
Affiliation:
Centro de Investigación Biomédica en Red de Salud Mental- CIBERSAM., Área de Psiquiatría - Universidad de Oviedo, Oviedo, Spain
E. Díaz-Mesa
Affiliation:
Centro de Investigación Biomédica en Red de Salud Mental- CIBERSAM., Área de Psiquiatría - Universidad de Oviedo, Oviedo, Spain
E. Martínez-Santamaría
Affiliation:
Centro Asistencial “AS Burgas”, Unidad de Conductas Adictivas - Hospital Santa María Nai, Orense, Spain
G. Florez
Affiliation:
Hospital Santa María Nai, Unidad de Conductas Adictivas, Orense, Spain
M. Arrojo
Affiliation:
Complejo Hospitalario Universitario de Santiago, Psiquiatría, Santiago de Compostela, Spain
M.P. García-Portilla
Affiliation:
Universidad de Oviedo, Área de Psiquiatría - CIBERSAM, Oviedo, Spain
J. Bobes
Affiliation:
Universidad de Oviedo, Área de Psiquiatría - CIBERSAM, Oviedo, Spain
*
*Corresponding author.

Abstract

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Introduction

Tobacco use has been associated with more excitement and agitation symptoms, greater severity of global psychopathology as measured by the Clinical General Impression (CGI) Scale, and psychotic symptoms in patients with schizophrenia.

Aim

To assess the effects of nicotine abstinence versus nicotine maintenance on the clinical symptoms of a sample of outpatients smokers diagnosed with schizophrenia.

Methods

Sample: 81 outpatients with schizophrenia [72.8% males; mean age (SD) = 43.35 (8.82)] currently smoking tobacco [no. of cigarettes (SD) = 27.96 (12.29)]. Desing: non-randomized, open-label, 6-month follow-up and multi-center study conducted at 3 sites in Spain (Oviedo, Santiago de Compostela and Orense). Instruments: Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression for Schizophrenia (CGI-SCH), Hamilton Depression Rating Scale (HDRS). Antropometric measures: Body mass index (BMI) and waist circumference. Vital sings: heart rate. Procedure: Patients were assigned to 2 conditions:

– control group = patients continuing their tobacco use;

– experimental group = patients participated in vareniclina or nicotine patches treatment for smoking cessation.

Patients were evaluated at baseline (all patients smoking) and after 3 and 6 months.

Results

No significant differences (P>.05) were found between groups at baseline evaluation. Likewise, there were no significant differences between smokers and non-smokers after treatment (3 and 6 months follow-up) in their clinical symptomatology (according to PANSS, HDRS and CGI-SCH), anthropometric measures and heart rate.

Conclusions

No significant differences were found in the clinical symptoms after a period of nicotine abstinence. Therefore, clinicians should motivate and help their patients to quit smoking (CIBERSAM - FIS PI11/01891).

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EW551
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. s261 - s262
Copyright
Copyright © European Psychiatric Association 2014
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