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EPA-0163 – The Adverse Children Experience in Sjogren's Syndrome Adult Patients Suffering Mental Disorders

Published online by Cambridge University Press:  15 April 2020

O. Shelomkova ,
D. Veltishchev ,
V. Vasiliev ,
T. Lisitsyna ,
O. Kovalevskaya ,
O. Seravina ,
V. Krasnov  and
E. Nasonov
O. Shelomkova
Affiliation:
Stress -Related Disorders, Moscow Research Institute of Psychiatry MoH RF, Moscow, Russia
D. Veltishchev
Affiliation:
Stress -Related Disorders, Moscow Research Institute of Psychiatry MoH RF, Moscow, Russia
V. Vasiliev
Affiliation:
Laboratory Iintensive Therapy of Rheumatic Diseases, Research Institute of Rheumatology RAMS, Moscow, Russia
T. Lisitsyna
Affiliation:
Laboratory of Systemic Rheumatic Diseases Department of Vascular Disease, Research Institute of Rheumatology RAMS, Moscow, Russia
O. Kovalevskaya
Affiliation:
Stress -Related Disorders, Moscow Research Institute of Psychiatry MoH RF, Moscow, Russia
O. Seravina
Affiliation:
Stress -Related Disorders, Moscow Research Institute of Psychiatry MoH RF, Moscow, Russia
V. Krasnov
Affiliation:
Director of Moscow Research Institute of Psychiatry, Moscow Research Institute of Psychiatry, Moscow, Russia
E. Nasonov
Affiliation:
Director of Research Institute of Rheumatology RAMS, Research Institute of Rheumatology RAMS, Moscow, Russia

Abstract

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Introduction:

The adverse experience in childhood (parental deprivation mostly) (AEC) has an important role in predisposing to mood and immuno-inflammatory rheumatic disorders in adults via chronic stress mechanisms. The primary Sjögren's Syndrome (SS) - a chronic, systemic autoimmune disease, which has some common pathogenic links with stress-related mental disorders.

Objectives/Aims:

To evaluate the AEC and MD presentation in SS patients.

Methods:

80 inpatients (mean age 46,2+12,3 yrs) suffering SS were enrolled in the study. MD were diagnosed in accordance with ICD-10 criteria. The severity of depression, anxiety, stress were measured with HADS, MADRS, HAM-A, PSS-10.

Results:

The AEC had 78,7% of SS patients (recurrent events – 32,5%). Patients with AEC had an increased risk of developing dysthymia (OR=1,34; 95% CI=0,26–6,83) and depressive episode (OR=1,75 (0,35–8,65)) in adults. Recurrent depression was not revealed in patients with ACE. However, patients with AEC had no reliable differences in the MADRS, HAM-A, HADS, PSS-10 compared to patients without AEC. Patients with AEC had an increased risk of suicide attempts (OR=2,15; (0,25–37,2)) and suicidal thoughts (OR=4,58; (0,25–18,5)). The reliable correlations of the severity of SS symptoms (dry eyes/mouth, lymphoma) and AEC have not been confirmed. Patients with AEC had early onset SS (33,6±13,0 vs 38,1±14,2) and MD (28,4±12,6 vs 34,1±13,5) than patients without AEC.

Conclusion:

AE? is a significant risk factor for depression and suicidal thoughts and attempts in patients suffering SS.

Type
EPW35 - Consultation Liaison Psychiatry and Psychosomatics 3
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
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