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EPA-0232 - Epigenetic Alteration in ALDH2-metabolism in Alcohol-dependent Patients

Published online by Cambridge University Press:  15 April 2020

T. Hillemacher ,
H. Frieling ,
S. Bleich ,
M. Rhein  and
M. Haschemi-Nassab
T. Hillemacher
Affiliation:
Department for Psychiatry, Hannover Medical School, Hannover, Germany
H. Frieling
Affiliation:
Department for Psychiatry, Hannover Medical School, Hannover, Germany
S. Bleich
Affiliation:
Department for Psychiatry, Hannover Medical School, Hannover, Germany
M. Rhein
Affiliation:
Department for Psychiatry, Hannover Medical School, Hannover, Germany
M. Haschemi-Nassab
Affiliation:
Department for Psychiatry, Hannover Medical School, Hannover, Germany

Abstract

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Introduction:

Changes in DNA-methylation patterns in alcohol-dependent patients have been described in various studies. However, epigenetic regulation of genes responsible for the ethanol metabolism has not been in the focus of recent research.

Objective:

Aim of our study was to evaluate changes in DNA-methylation of the aldehyde dehydrogenase 2 (ALDH2) in respect to genetic variants (rs886205 ALDH2-SNP) in blood samples of alcohol-dependent patients compared with healthy controls.

Methods:

During an inpatients detoxification treatment we draw blood samples from 82 alcohol-dependent, male patients on day 1, day 7 and day 14. Bisulfite-treated DNA was subjected to methylation analysis via sequencing. Findings of the alcohol-dependent group were compared with results of a healthy control group (N=34)

Results:

Our results show decreasing methylation levels of a repressive ALDH2 promoter fragment to control levels only in homozygous A-allele patients of the rs886205 SNP.

Conclusion:

Findings of this study reveal a specific genetic-epigenetic interaction in ALDH2 regulation which may have crucial importance for the understanding of epigenetic regulation of ethanol metabolism in humans

Type
EPW03 - Addictive Behaviours 1
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
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