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EPA-0299 - Agomalatine is Effective in Reducing Insomnia in Abstinent Alcohol-dependent Patients

Published online by Cambridge University Press:  15 April 2020

M. Grosshans ,
J. Mutschler ,
M. Luderer ,
K. Mann  and
F. Kiefer
M. Grosshans
Affiliation:
Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
J. Mutschler
Affiliation:
Department of Psychiatry, University of Zürich, Zürich, Switzerland
M. Luderer
Affiliation:
Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
K. Mann
Affiliation:
Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
F. Kiefer
Affiliation:
Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany

Abstract

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Introduction:

Among abstinent alcohol-dependent patients, sleep disorders are a wide-spread and persistent problem and have been associated with the risk of alcohol relapse. The melatonin-agonist agomelatine has been shown to improve overall sleep quality without daytime sedation.

Aims:

To examine the effect of agomelatine on sleep quality in abstinent alcohol-dependet patients suffering from chronic sleep disorders.

Methods:

9 alcohol-dependet patients suffering from chronic sleep disorders received nightly doses between 25 and 50 mg of agomelatine. Sleep quality was assesed using the Pittsburgh Sleep Quality Index prior and following 6 weeks of treatment with agomelatine. Prior and during treatment with agomelatine all patients were monitored for serum levels of liver enzymes.

Results:

After 6 weeks of agomelatine treatment, the Pittsburgh Sleep Quality Index global score for all patients had decreased significantly.

Conclusions:

The present data suggest that agomelatine may improve the sleep quality of alcohol-dependent patients suffering from chronic sleep disorders.

Type
EPW18 - Addictive Behaviours 2
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
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