EPA-0630 – Cis and Transactional Model on the Mutual Interaction of Mood and Personality: Study on 4300 Patients with Millon's Clinical Multiaxial Inventory III

Abstract

Objectives:

Evaluation of mood and personality interaction

Materials and Methods:

Patients underwent evaluation with MCMI-III, clinical interview for psychological or non psychological reasons (4300) and Beck's or Hamilton (320). Scores of mood and personality were studied for correlation. A model of cis-action and trans-action was developed.

Results:

1. 1. Schizotypal, borderline, avoidant, dependent and self destructive personalities are more prone to mood disorders with more intense symptoms and less responsiveness to medication. P<0.03

2. 2. Schizoid, paranoid, narcissistic and histrionic personalities are less prone to mood disorders than the general population. P<0.04

3. 3. Schizoid, schizotypal, borderline and histrionic patterns show higher subclinical scores in mood disorder. P<0.1

4. 4. Major depression augments schizoid, schizotypal, borderline, narcissistic, avoidant and dependent personality symptoms. Patients showed reduced personality scores and less symptoms after treatment for mood disorders. P<0.02

5. 5. These latter personalities improve with their symptoms after antidepressants even if they do not fulfill clinical criteria for mood disorders as (MCMI-III and clinical interview). P<0.03

6. 6. Curiously, almost all personality patterns improve with their symptoms even without mood problems if treated for short courses of antidepressants. P<0.01

7. 7. Antidepressants probably disrupt persistent maladaptive neural circuits in almost all patients with different psychopathologies.

Conclusions:

1. 1. Mood and personality interact in a cis pattern: they augment each other and trans pattern: they reduce the chance of the development or the expression and intensity of the other.

2. 2. Personality disorders are not extreme of a spectrum of points of view and … but categorically distinguishable patterns with neuro-humoral backgrounds.