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EPA-0671 – Association Study Between Toll-Like Receptors 2 and 4 Single Nucleotide Polymorphisms and Bipolar Disorder

Published online by Cambridge University Press:  15 April 2020

J. Oliveira ,
B. Etain ,
W. Boukouaci ,
K. Amokrane ,
M. Bennabi ,
F. Bellivier ,
C. Henry ,
J. Kahn ,
D. Charron  and
R. Krishnamoorthy
...Show all authors
J. Oliveira
Affiliation:
INSERM U 955 - Psychiatrie Génétique, Institut Mondor de Recherche Biomédicale, Créteil, France
B. Etain
Affiliation:
INSERM U 955 - Psychiatrie Génétique, Institut Mondor de Recherche Biomédicale, Créteil, France
W. Boukouaci
Affiliation:
INSERM UMRS 940 - Hématologie- Immunologie-Cibles thérapeutiques, Institut Universitaire d’Hématologie, Paris, France
K. Amokrane
Affiliation:
INSERM UMRS 940 - Hématologie- Immunologie-Cibles thérapeutiques, Institut Universitaire d’Hématologie, Paris, France
M. Bennabi
Affiliation:
INSERM UMRS 940 - Hématologie- Immunologie-Cibles thérapeutiques, Institut Universitaire d’Hématologie, Paris, France
F. Bellivier
Affiliation:
INSERM U 955 - Psychiatrie Génétique, Institut Mondor de Recherche Biomédicale, Créteil, France
C. Henry
Affiliation:
INSERM U 955 - Psychiatrie Génétique, Institut Mondor de Recherche Biomédicale, Créteil, France
J. Kahn
Affiliation:
Service de Psychiatrie et Psychologie Clinique, Centre Hospitalier Universitaire de Nancy, Nancy, France
D. Charron
Affiliation:
INSERM UMRS 940 - Hématologie- Immunologie-Cibles thérapeutiques, Institut Universitaire d’Hématologie, Paris, France
R. Krishnamoorthy
Affiliation:
INSERM U 763, Hôpital Robert Debré, Paris, France
M. Leboyer
Affiliation:
INSERM U 955 - Psychiatrie Génétique, Institut Mondor de Recherche Biomédicale, Créteil, France
R. Tamouza
Affiliation:
INSERM UMRS 940 - Hématologie- Immunologie-Cibles thérapeutiques, Institut Universitaire d’Hématologie, Paris, France

Abstract

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Introduction:

Immune dysfunction is thought to play a critical role in the pathophysiology of bipolar disorder (BD). Better insight into the genetic control of innate immune responses is of importance due to possible interactions with environmental risk factors such as infectious agents, particularly early in life.

Objectives:

Given the importance of Toll-like receptors (TLRs) in innate immunity, we analysed the association of selected genetic variants of TLR-2 and TLR-4, both major sensors of pathogenic infectious and non-infectious structures, with BD.

Aims:

Explore possible implications of the innate arm of the immune response in BD.

Methods:

Genomic DNAs from 572 BD patients and 202 controls were analyzed for the distribution of polymorphisms on the TLR-2 and TLR-4 loci using TaqMan®. Associations were examined using Chi-square test.

Results:

We found that TLR-4 rs1927914 AA and rs11536891 TT genotypes were more frequent in BD patients than in controls (corrected p; pc = .02 and .02 respectively) particularly in early-onset BD (EOBD) patients (pc = .004 and .006) born during the summer season (pc = 02 and .002 respectively). We also found that TLR-2 rs3804099 TT and rs4696480 TT genotypes were significantly more prevalent in EOBD group as compared to the late-onset BD (LOBD) subset, the latter only after excluding patients with positive family history of psychiatric disorders (pc=0.024 and 0.002 respectively).

Conclusions:

We report an association between BD and TLR-2 and TLR-4 genetic variants suggesting an important role for pathogens in disease development.

Type
E07 – e-Poster Oral Session 07: Neurobiology, Bipolar Disorders and psychopathology
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
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