EPA-0991 – Possibilities to Reduce the Severity of Post-Stroke Dementia Among Patients After Massive Stroke by Means of Transluminal Laser Revascularization Method

Abstract

Introduction:

The research investigates the possibility of reducing the level of post-stroke dementia.

Methods:

The research involved 92 patients after massive ischemic stroke aged 32–72. The patients underwent: CDR, MMSE, cerebral CT, MRI, SG, REG, cerebral multi-gated angiography (MUGA).

Initial dementia and cognitive impairment severity was identified among 33 patients (35.87%):

• moderate dementia (CDR-2) - 18 (54.55%) patients (MMSE 11–18);

• severe dementia (CDR-3) - 15 (45.45%) patients (MMSE 7–10).

Transluminal treatment was performed in 68 cases - Test Group.

Conservative treatment was performed in 24 cases - Control Group.

Results:

Test Group. Good immediate angiographic outcome manifested in the restoration of vessels lumen and patency, as well as in collateral revascularization, was achieved in 66 (95.59%) cases. The following positive trend was observed in 12–24 months:

1. ■ Absence of dementia signs, cognitive function restoration to MMSE 28–30 - 14 (20.59%) patients;

2. ■ Dementia severity reduction to CDR-1, cognitive function restoration to MMSE 21–27 - 30 (44.12%) patients;

3. ■ Dementia severity reduction to CDR-2, cognitive function restoration to MMSE 17–20 - 24 (35.29%) patients;

Control Group. The following was observed in 12–24 months:

1. ■ Dementia severity reduction to CDR-1, cognitive function restoration to MMSE 21–26 - 2 (8.33%) patients;

2. ■ Dementia severity reduction to CDR-2, cognitive function restoration to MMSE 17–20 - 5 (20.83%) patients;

3. ■ Absence of clear signs of declining dementia - 17 (70.85%) patients.

Conclusion:

Transluminal laser revascularization of cerebral blood vessels is more efficient than therapy in the treatment of ischemic stroke; it can significantly reduce dementia level and bring patients back to their normal active life.