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Evolution of inflammatory dysregulation and oxidative stress in patients with first episode of mania

Published online by Cambridge University Press:  23 March 2020

S. García ,
P. López Peña ,
I. Zorrilla ,
A. García-Alocen ,
M. Martínez-Cengotitabengoa ,
C. Bermúdez-Ampudia ,
K.S. Mac-Dowell ,
S. Rodríguez ,
J.C. Leza  and
A. González-Pinto
S. García*
Affiliation:
University Hospital of Araba Santiago, Psychiatry, Vitoria-Gasteiz, Spain University of the Basque Country, neuroscience, Bizkaia, Spain
P. López Peña
Affiliation:
University Hospital of Araba Santiago, Psychiatry, Vitoria-Gasteiz, Spain University of the Basque Country, neuroscience, Bizkaia, Spain
I. Zorrilla
Affiliation:
University Hospital of Araba Santiago, Psychiatry, Vitoria-Gasteiz, Spain
A. García-Alocen
Affiliation:
University Hospital of Araba Santiago, Psychiatry, Vitoria-Gasteiz, Spain
M. Martínez-Cengotitabengoa
Affiliation:
University Hospital of Araba Santiago, Psychiatry, Vitoria-Gasteiz, Spain National Distance Education University UNED, Associated Center of Vitora, Vitoria, Spain Biomedical Research Centre in Mental Health Network CIBERSAM, Psychiatry, University Hospital of Araba, Vitoria, Spain
C. Bermúdez-Ampudia
Affiliation:
University Hospital of Araba Santiago, Psychiatry, Vitoria-Gasteiz, Spain
K.S. Mac-Dowell
Affiliation:
Faculty of Medicine, Complutense University and Health Research Institute-IIS-12 de Octubre Hospital i + 12, Pharmacology, Madrid, Spain Biomedical Research Centre in Mental Health Network CIBERSAM, Pharmacology, Faculty of Medicine, Complutense University, Madrid, Spain
S. Rodríguez
Affiliation:
Faculty of Medicine, Complutense University and Health Research Institute-IIS-12 de Octubre Hospital i + 12, Pharmacology, Madrid, Spain
J.C. Leza
Affiliation:
Faculty of Medicine, Complutense University and Health Research Institute-IIS-12 de Octubre Hospital i + 12, Pharmacology, Madrid, Spain Biomedical Research Centre in Mental Health Network CIBERSAM, Pharmacology, Faculty of Medicine, Complutense University, Madrid, Spain
A. González-Pinto
Affiliation:
University Hospital of Araba Santiago, Psychiatry, Vitoria-Gasteiz, Spain University of the Basque Country, neuroscience, Bizkaia, Spain Biomedical Research Centre in Mental Health Network CIBERSAM, Psychiatry, University Hospital of Araba, Vitoria, Spain
*
* Corresponding author.

Abstract

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Introduction

Recent studies have focused on the imbalance in inflammatory and antioxidant pathways as possible causes of the underlying neurodegenerative processes in bipolar disorder. Thus, the study of these pathways in first episodes of mania (FEM) can increase knowledge about this issue.

Aim

To compare plasma concentrations of pro-inflammatory (MCP-1, PGE2, TNFα) and oxidative parameters (TAS, NO2 and TBARS) between controls and FEM patients and to analyze the evolution of these parameters in patients from baseline to 6 months assessment time.

Methods

This study included 44 FEM patients and 79 healthy controls, aged 18 to 40. Blood samples were available for controls at baseline and for patients at baseline and 6 months after. TAS and TBARS were measured using non-EIA assay kits, N02 was measured with Griess method and PGE2, MCP-1 and TNFα with ELISA kits.

Results

At baseline, TAS was significantly lower in patients than in controls and TBARS, MCP-1 and TNFα were significantly higher in patients. Among patients, TAS and MCP1 were lower at 6 months than at the illness onset and PGE2 and NO2 were significantly higher than at baseline.

Conclusion

Patients presented an increased oxidative damage and also a higher activation of pro-inflammatory pathways than healthy controls at baseline. After 6 months their level of oxidative stress continue increased. Pro-inflammatory parameters decreased overtime (MCP-1 and TNF α) but PGE2, increased surprisingly. This can be due to the fact that antipsychotics are not able to completely reverse baseline inflammation.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV167
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S331
Copyright
Copyright © European Psychiatric Association 2016
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