Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-14T04:35:41.928Z Has data issue: false hasContentIssue false
  • English
  • Français

Food matters: Anorexia nervosa and the microbiome: First findings of a European cooperation

Published online by Cambridge University Press:  13 August 2021

B. Herpertz-Dahlmann ,
J. Seitz ,
R. Adan ,
S. Fetissov ,
J. Baines ,
A. Karwautz  and
A. Van Elburg
B. Herpertz-Dahlmann*
Affiliation:
Department Of Child And Adolescent Psychiatry, RWTH Aachen University, Aachen, Germany
J. Seitz
Affiliation:
Department Of Child And Adolescent Psychiatry, RWTH Aachen University, Aachen, Germany
R. Adan
Affiliation:
Translational Neuroscience, UMCU, Utrecht, Netherlands
S. Fetissov
Affiliation:
Faculte Des Sciences, Inserm UMR 1239, Rouen, France
J. Baines
Affiliation:
Institute For Experimental Medicine, Christian´s Albrecht University of Kiel, Kiel, Germany
A. Karwautz
Affiliation:
Department Of Child And Adolescent Psychiatry, Medical University Vienna, Wien, Austria
A. Van Elburg
Affiliation:
Adolescent Eating Disorders, Altrecht Eating Disorders Rintveld, Zeist and Department of Social Sciences, University of Utrecht, Utrecht, Netherlands
*
*Corresponding Author.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Anorexia nervosa (AN) is one of the most common chronic disorders in adolescence with still high mortality rates. Knowledge on gut-brain interaction might help to develop new treatments, as severe starvation-induced changes of the microbiome in AN-patients have been demonstrated, which do not alleviate with weight gain. In our own pilot study alpha-diversity was increased in patients with AN after short-term weight recovery, while beta diversity showed clear group differences with healthy controls before and after weight gain. A reduction of taxa belonging to Enterobacteriaceae at admission and discharge and an increase in taxa belonging to Lachnospiraceae at discharge were typically found in patients with AN. The work plan of our European project comprises an observational study and two phase II RCTs with the application of omega-3-PUFA and a multistrain psychobiotic to both, humans and rodents. With the help of a well-established animal model for AN (activity-based anorexia, ABA), the effect of stool transplants from patients to rodents will be analysed. Longitudinal MRI will be conducted in rodents together with cellular and molecular brain analyses. In addition, immune response and circulating antibodies associated with the presence of certain bacterial strains and interaction with hunger and satiety hormones will be explored. We hope that by this translational research we may systematically investigate the role of an altered microbiome for the course of AN and to identify new therapeutic tools.

Disclosure

This project is funded by ERA-NET of the European Union.

Keywords

low grade inflammationanorexia nervosaMicrobiomebody weight
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S28
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
Submit a response

Comments

No Comments have been published for this article.