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Formal thought disorder in schizophrenia and bipolar disorder: A systematic review and meta-analysis

Published online by Cambridge University Press:  23 March 2020

K. Alptekin ,
B. Yalincetin ,
E. Bora  and
A. Berna
K. Alptekin
Affiliation:
Dokuz Eylul University, Psychiatry, Izmir, Turkey
B. Yalincetin
Affiliation:
Medical Sciences, Neuropsychiatry, Izmir, Turkey
E. Bora
Affiliation:
Dokuz Eylul University, Psychiatry, Izmir, Turkey
A. Berna
Affiliation:
Dokuz Eylul University, Psychiatry, Izmir, Turkey

Abstract

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Historically, formal thought disorder has been considered as one of the distinctive symptoms of schizophrenia. However, research in last few decades suggested that there is a considerable clinical and neurobiological overlap between schizophrenia and bipolar disorder (BP). We conducted a meta-analysis of studies comparing positive (PTD) and negative formal thought disorder (NTD) in schizophrenia and BP. We included 19 studies comparing 715 schizophrenia and 474 BP patients. In the acute inpatient samples, there was no significant difference in the severity of PTD (d = –0.07, CI = –0.22–0.09) between schizophrenia and BP. In stable patients, schizophrenia was associated with increased PTD compared to BP (d = 1.02, CI = 0.35–1.70). NTD was significantly more severe (d = 0.80, CI = 0.52–0.1.08) in schizophrenia compared to BP. Our findings suggest that PTD is a shared feature of both schizophrenia and BP but persistent PTD or NTD can distinguish subgroups of schizophrenia from BP and schizophrenia patients with better clinical outcomes.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster walk: Schizophrenia and other psychotic disorders–part 1
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S185
Copyright
Copyright © European Psychiatric Association 2017
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