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Functional connectivity between brain regions underlying executive control and language in schizophrenia patients with history of auditory verbal hallucinations

Published online by Cambridge University Press:  13 August 2021

Y. Panikratova ,
I. Lebedeva ,
A. Tomyshev ,
V. Kaleda  and
R. Vlasova
Y. Panikratova
Affiliation:
Laboratory Of Neuroimaging And Multimodal Analysis, FSBSI Mental Health Research Center, Moscow, Russian Federation
I. Lebedeva
Affiliation:
Laboratory Of Neuroimaging And Multimodal Analysis, FSBSI Mental Health Research Center, Moscow, Russian Federation
A. Tomyshev*
Affiliation:
Laboratory Of Neuroimaging And Multimodal Analysis, FSBSI Mental Health Research Center, Moscow, Russian Federation
V. Kaleda
Affiliation:
Department Of Youth Psychiatry, FSBSI Mental Health Research Center, Moscow, Russian Federation
R. Vlasova
Affiliation:
Department Of Psychiatry, University of North Carolina, Chapel Hill, United States of America
*
*Corresponding author.

Abstract

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Introduction

Schizophrenia patients with auditory verbal hallucinations (AVH) demonstrate impaired functional connectivity (FC) between brain regions, involved in executive functions and language. However, as most studies compare patients to healthy controls, the specificity of these findings either for schizophrenia in general or for AVH is unclear.

Objectives

We aimed to compare whole-brain resting-state FC of main language brain regions between schizophrenia patients with and without history of AVH and healthy controls.

Methods

Schizophrenia male patients with (n=31; mean age 29,8±11,6) or without history of AVH (n=16; 29±12,4) and 39 healthy male controls (30±8,9) underwent resting-state fMRI on 3T Philips scanner. No between-group differences in age, illness duration, and severity of clinical symptoms except AVH were revealed. Regions of interest (ROIs) were taken from the independent fMRI study with conventional language localizer and included left inferior frontal gyrus (l_IFG) and superior temporal gyri (STG) bilaterally. Whole-brain FC of each ROI was compared between groups (ANCOVA; p<.005 voxelwise; p(FDR)<.017 clusterwise, corrected for number of ROIs) with post hoc tests.

Results

Decreased FC between each STG (left and right) and anterior cingulate cortex (ACC) was revealed in all patients, compared to healthy controls. Patients with history of AVH, compared to other groups, showed decreased FC between l_IFG and ACC.

Conclusions

Disrupted fronto-temporal FC is non-specific for AVH and characterizes all schizophrenia patients. Patients with history of AVH have impaired FC between the l_IFG, underlying language production, and ACC, involved in differentiation between language production and comprehension. The study was supported by RFBR grant 18-013-01214.

Conflict of interest

The study was supported by RFBR grant 18-013-01214.

Keywords

schizophréniaauditory verbal hallucinationsresting-state fMRIfunctional connectivity
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S416
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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