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The genetics of neurosystems in mental ill-health and suicidality: Beyond serotonin

Published online by Cambridge University Press:  16 April 2020

D. Rujescu  and
I. Giegling
D. Rujescu*
Affiliation:
Department of Psychiatry, Ludwig-Maximilians University, Nußbaumstr. 7, 80336München, Germany
I. Giegling
Affiliation:
Department of Psychiatry, Ludwig-Maximilians University, Nußbaumstr. 7, 80336München, Germany
*
*Corresponding author. Tel.: +49 89 5160 5756; fax: +49 89 5160 5779. E-mail address: Dan.Rujescu@med.uni-muenchen.de (D. Rujescu).
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Abstract

Suicidal behavior is a major health problem worldwide. The risk of suicide-related behavior is supposed to be determined by a complex interplay of sociocultural factors, psychiatric history, personality traits, and genetic vulnerability. Family and twin studies point towards a partial heritability of suicidal behavior. First molecular genetic studies concentrated on genes of the serotonergic system based on the biochemical evidence that serotonergic neurotransmission is implicated in this behavior. Furthermore, genes of e.g. the dopaminergic and noradrenergic neurotransmitter systems have also been the subject of investigations in this context. The aim of this article is to review molecular genetic studies in suicidal behavior beyond the serotonergic system and to emphasize findings on new genes.

Keywords

SuicideAggressionGeneticsSerotoninImpulsivityPolymorphism
Type
Original article
Information
European Psychiatry , Volume 25 , Issue 5: The role of genetics in promoting suicide prevention and the mental health of the population - Nobel Conference: The role of genetics in promoting suicide prevention and the mental health of the population , June 2010 , pp. 272 - 274
Copyright
Copyright © Elsevier Masson SAS 2010

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