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Immune heterogeneity of non-psychotic mental disorders

Published online by Cambridge University Press:  13 August 2021

S. Zozulya ,
L. Androsova ,
I. Otman ,
T. Vetlugina ,
V. Nikitina  and
T. Klyushnik
S. Zozulya*
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
L. Androsova
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
I. Otman
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
T. Vetlugina
Affiliation:
Laboratory Of Clinical Psychoneuroimmunology And Neurobiology, Mental Health Research Institute, Tomsk National Research Medical Center, Tomsk, Russian Federation
V. Nikitina
Affiliation:
Laboratory Of Clinical Psychoneuroimmunology And Neurobiology, Mental Health Research Institute, Tomsk National Research Medical Center, Tomsk, Russian Federation
T. Klyushnik
Affiliation:
Laboratory Of Neuroimmunology, Mental Health Research Centre, Moscow, Russian Federation
*
*Corresponding author.

Abstract

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Introduction

Current studies indicate the involvement of inflammation in the pathogenesis of chronic non-infectious diseases, and therefore it is of interest to study the role of inflammation markers in non-psychotic mental disorders (NPMD).

Objectives

To identify a number of inflammatory markers in serum of patients with NPMD.

Methods

73 patients with NPMD were examined (F43.2; F06.6). The comparison group consisted of 76 patients with endogenous psychosis (EGP) (F20.0; F25.0). The control group included 80 healthy people. The serum activity of leukocyte elastase (LE), α1-proteinase inhibitor (α1-PI) and the level of autoantibodies (aAb) to neuroantigens were determined.

Results

Three groups of patients with different variants of inflammatory response to the pathological process were identified. In group 1 (23.3%), all indices corresponded to the control values, which indicated the absence of the pathological process in brain. In group 2, there was a significant increase in activity both LE and α1-PI compared to control (p<0.05). This type of immune reaction characterized a balanced inflammatory response. It was found in 52% of patients with NPMD and in all patients with EGP. The aAb level also exceeded the control values (p<0.05). Group 3 (24.7%) showed an increase in α1-PI activity (p<0.05), but not in LE activity compared to control. Insufficient LE activity reflects a decrease in the functional activity of neutrophils.

Conclusions

The immune heterogeneity of NPMD according to the level of inflammatory markers was identified. 52% of patients with NPMD have a pronounced activation of inflammatory reactions accompanied by increased levels of aAb to neuroantigens.

Keywords

non-psychotic mental disordersinflammatory markers
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S472
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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