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Insomnia associated with neutrophil/lymphocyte ratio in female patients with schizophrenia

Published online by Cambridge University Press:  13 August 2021

G. Paniagua ,
L. González-Blanco ,
F. Dal Santo ,
C. Martínez-Cao ,
C. Moya-Lacasa ,
M. Valtueña-García ,
E. Martín Gil ,
L. García-Alvarez ,
P.A. Saiz  and
M.P. García-Portilla
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G. Paniagua*
Affiliation:
Department Of Psychiatry, University of Oviedo, Oviedo, Spain Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain Csm Eria, Servicio Salud Principado Asturias, University of Oviedo, Asturias, Oviedo, Asturias, Spain
L. González-Blanco
Affiliation:
Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain Neuroscience And Sense Organs, ISPA HEALTH RESEARCH INSTITUTE OF THE PRINCIPALITY OF ASTURIAS, Oviedo, Spain Deparment Of Psychiatry, University of Oviedo/CIBERSAM, Oviedo, Spain
F. Dal Santo
Affiliation:
Department Of Psychiatry, University of Oviedo, Oviedo, Spain Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain Psychiatry, Hospital Universitario Central de Asturias, Oviedo, Spain
C. Martínez-Cao
Affiliation:
Department Of Psychiatry, University of Oviedo, Oviedo, Spain
C. Moya-Lacasa
Affiliation:
Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain
M. Valtueña-García
Affiliation:
Department Of Psychiatry, University of Oviedo, Oviedo, Spain
E. Martín Gil
Affiliation:
Department Of Psychiatry, University of Oviedo, Oviedo, Spain
L. García-Alvarez
Affiliation:
Neuroscience And Sense Organs, ISPA HEALTH RESEARCH INSTITUTE OF THE PRINCIPALITY OF ASTURIAS, Oviedo, Spain Deparment Of Psychiatry, University of Oviedo/CIBERSAM, Oviedo, Spain
P.A. Saiz
Affiliation:
Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain Neuroscience And Sense Organs, ISPA HEALTH RESEARCH INSTITUTE OF THE PRINCIPALITY OF ASTURIAS, Oviedo, Spain Deparment Of Psychiatry, University of Oviedo/CIBERSAM, Oviedo, Spain
M.P. García-Portilla
Affiliation:
Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain Neuroscience And Sense Organs, ISPA HEALTH RESEARCH INSTITUTE OF THE PRINCIPALITY OF ASTURIAS, Oviedo, Spain Deparment Of Psychiatry, University of Oviedo/CIBERSAM, Oviedo, Spain
J. Bobes
Affiliation:
Psychiatry, SESPA Mental Health Services of Principado de Asturias, OVIEDO, Spain Neuroscience And Sense Organs, ISPA HEALTH RESEARCH INSTITUTE OF THE PRINCIPALITY OF ASTURIAS, Oviedo, Spain Deparment Of Psychiatry, University of Oviedo/CIBERSAM, Oviedo, Spain
*
*Corresponding author.

Abstract

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Introduction

Worse sleep quality and increased inflammatory markers in women with schizophrenia (Sch) have been reported (Lee et al. 2019). However, the physiological mechanisms underlying the interplay between sleep and the inflammatory pathways are not yet well understood (Fang et al. 2016).

Objectives

Analyze the relationship between Neutrophil/Lymphocyte (NLR), Monocyte/Lymphocyte (MLR) and Platelet/Lymphocyte (PLR) ratios, and insomnia in Sch stratified by sex.

Methods

Final sample included 176 Sch patients (ICD-10 criteria) [mean age: 38.9±13.39; males: 111(63.1%)]. Assessment: PANSS, Calgary Depression Scale (CDSS), and Oviedo Sleep Questionnaire (OSQ) to identify a comorbid diagnosis of insomnia based on ICD-10. Fasting counting blood cell were performed to calculate ratios. Statistics: U Mann-Whitney, logistic regression.

Results

Insomnia as comorbid diagnosis was present in 22 Sch (12.5%) with no differences between sex [14 males (12.6%), 8 females (12.3%)], neither in their age. Female patients with insomnia showed increased NLR [2.44±0.69 vs. 1.88±0.80, U=122.00 (p=0.034)]. However, no differences in PLR and MLR were found, neither in any ratio in males. Regression models using insomnia as dependent variable and covariates (age, PANSS-positive, PANSS-negative, CDSS) were estimated. Females: presence of insomnia was associated with NLR [OR=3.564 (p=0.032)], PANSS-positive [OR=1.263 (p=0.013)] and CDSS [OR=1.198 (p=0.092)]. Males: only PANSS-positive [OR=1.123 (p=0.027)] and CDSS scores [OR=1.220 (p=0.005)] were associated with insomnia.

Conclusions

NLR represent an inflammatory marker of insomnia in Sch but only in female patients. Improving sleep quality in these patients could help to decrease their inflammatory response.

Disclosure

No significant relationships.

Keywords

femaleschizophréniaInsomniaInflammation
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S806
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Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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