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The intensity dependence of auditoy ERP components in unmedicated patients with major depression. an analysis of group differences.

Published online by Cambridge University Press:  16 April 2020

T. Linka ,
G. Sartory ,
M. Gastpar  and
B.W. Mueller
T. Linka
Affiliation:
Vincent Van Gogh Instititute of Psychiatry, Venray, The Netherlands Clinic for Psychiatry and Psychotherapy, Rheinische Kliniken Essen, University of Duisburg-Essen, Essen, Germany
G. Sartory
Affiliation:
Department of Clinical Psychology, University of Wuppertal, Wuppertal, Germany
M. Gastpar
Affiliation:
Clinic for Psychiatry and Psychotherapy, Rheinische Kliniken Essen, University of Duisburg-Essen, Essen, Germany
B.W. Mueller
Affiliation:
Clinic for Psychiatry and Psychotherapy, Rheinische Kliniken Essen, University of Duisburg-Essen, Essen, Germany

Abstract

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Background:

The intensity dependent amplitude change (IDAP) of auditory evoked Event Related Potential (ERP) components has been found to correlate with the level of central serotonergic neurotransmission and to be associated with response to certain antidepressants. However, it is currently unknown whether there is a general abnormality of the IDAP in patients with major depression. Therefore, the purpose of the present study was to compare the IDAP in unmedicated depressive individuals with that of healthy control subjects.

Methods:

We report the results of a study evaluating the change of auditory evoked P1, N1, P2 as well as P1/N1 and N1/P2 peak to peak amplitudes in 40 in-patients with major depressive episode prior to antidepressant treatment, and 44 healthy control subjects. Clinical symptoms of depression were assessed by means of standardized psychiatric rating scales (CGI, HDRS, HAMA and BDI).

Results:

In multivariate analyses of variance we found no group differences in the intensity dependent increase neither of the P1, N1, and P2 nor of the P1/N1 and N1/P2 peak to peak amplitudes between patients and controls.

Conclusions:

Our data revealed no general abnormality of the IDAP in patients with major depression in comparison to healthy control subjects.

Type
Poster Session 2: Depressive Disorders
Information
European Psychiatry , Volume 22 , Issue S1: 15th AEP Congress - Abstract book - 15th AEP Congress , March 2007 , pp. S236
Copyright
Copyright © European Psychiatric Association 2007
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