Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-17T05:44:17.252Z Has data issue: false hasContentIssue false
  • English
  • Français

Investigation of endocannabinoids and endocannabinoid-related compounds in obese subjects during an hedonic eating experimental test

Published online by Cambridge University Press:  23 March 2020

V. Ruzzi ,
A.M. Monteleone ,
F. Monaco ,
G. Fico ,
A. Cervino ,
U. Volpe  and
P. Monteleone
V. Ruzzi
Affiliation:
Second University of Naples, Department of Psychiatry, Naples, Italy
A.M. Monteleone
Affiliation:
Second University of Naples, Department of Psychiatry, Naples, Italy
F. Monaco
Affiliation:
Second University of Naples, Department of Psychiatry, Naples, Italy
G. Fico
Affiliation:
Second University of Naples, Department of Psychiatry, Naples, Italy
A. Cervino
Affiliation:
Second University of Naples, Department of Psychiatry, Naples, Italy
U. Volpe
Affiliation:
Second University of Naples, Department of Psychiatry, Naples, Italy
P. Monteleone
Affiliation:
University of Salerno, Department of Medicine and Surgery, Salerno, Italy

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

Hedonic eating refers to the consumption of food just for pleasure and not for energetic needs. Endocannabinoids and endocannabinoid-related compounds play an important role in food-related reward and are likely involved in hedonic eating.

Objectives

In a previous study we found that in normal weight healthy subjects plasma levels of 2 arachidonoylglycerol (2-AG) decreased progressively after food ingestion in both hedonic and non-hedonic eating condition, but they were significantly higher in hedonic eating. Plasma levels of anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), instead, progressively decreased in both eating conditions without significant differences.

Aims

In order to investigate the physiology of endocannabinoids in obesity, we assessed the responses of AEA, 2-AG, OEA and PEA to hedonic and non-hedonic eating in obese individuals.

Methods

Fourteen satiated obese patients consumed favorite (hedonic eating) and non-favorite (non-hedonic eating) foods in two experimental sessions. During the tests, blood was collected to measure peripheral levels of AEA, 2-AG, OEA and PEA.

Results

Plasma levels of 2-AG progressively decreased in non-hedonic eating whereas they gradually increased after hedonic eating. Plasma levels of AEA decreased progressively in non-hedonic eating, whereas they initially decreased after the exposure to the favorite food and then returned to baseline values after its consumption. The responses of OEA and PEA to favorite and non-favorite food did not show significant differences.

Conclusions

These findings demonstrate that, compared to normal weight healthy subjects, obese subjects exhibit different responses of peripheral endocannabinoids to the ingestion of food for pleasure and this could have implications for the onset/maintenance of obesity.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Eating Disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S551
Copyright
Copyright © European Psychiatric Association 2017
Submit a response

Comments

No Comments have been published for this article.